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Fefelova E.V.

Chita State Medical Academy

Maksimenya M.V.

Chita State Medical Academy

Putneva A.S.

Autonomous non-profit organization Medical Center «XXI Century»

Ushnitsky I.D.

M.K. Ammosov North-Eastern Federal University — Medical Institute»

Mishchenko M.N.

Chita State Medical Academy

Karavaeva T.M.

Chita State Medical Academy

The effect of vitamin D deficiency on the content of some soluble signaling molecules in the oral fluid in individuals with dental caries

Authors:

Fefelova E.V., Maksimenya M.V., Putneva A.S., Ushnitsky I.D., Mishchenko M.N., Karavaeva T.M.

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Journal: Stomatology. 2024;103(2): 12‑17

DOI: 10.17116/stomat202410302112

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Table of contents

THE EFFECT OF VITAMIN D DEFICIENCY ON THE CONTENT OF SOME SOLUBLE SIGNALING MOLECULES IN THE ORAL FLUID IN INDIVIDUALS WITH DENTAL CARIES
THE EFFECT OF VITAMIN D DEFICIENCY ON THE CONTENT OF SOME SOLUBLE SIGNALING MOLECULES IN THE ORAL FLUID IN INDIVIDUALS WITH DENTAL CARIES

To cite this article:

Fefelova EV, Maksimenya MV, Putneva AS, Ushnitsky ID, Mishchenko MN, Karavaeva TM. The effect of vitamin D deficiency on the content of some soluble signaling molecules in the oral fluid in individuals with dental caries. Stomatology. 2024;103(2):12‑17. (In Russ.)
https://doi.org/10.17116/stomat202410302112

Подписка 2025-2 (Stomatology)
 
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OBJECTIVE

The aim of the sthudy is to sthudy the level of soluble Immune Checkpoint Molecules (B7.2, CTLA-4, Tim-3, Lag-3, PD-1) in the oral fluid during dental caries with the background of a lack and/or deficiency of 25-hydroxy-vitamin D in body.

MATERIALS AND METHODS

During the research 3 groups of people were formed, each one of them included 17 people aged from 20 to 24 years. The first group included students with high-intensity caries (above 9 DMFt index) and 25-hydroxy-vitamin D levels in blood serum >30 ng/ml, the second included students with high caries intensity and 25-hydroxy-vitamin D levels <30 ng/ml. The control group consisted of students with an average DMFt index of 1.5 (from 0 to 3) and a level of 25(OH)D in the blood more than 30 ng/ml. To determine the content of B7.2 (CD86), CTLA-4, Tim-3, Lag-3, PD-1, the Human Vascular Inflammation Panel 1 multiplex analysis kit from Biolegend (USA) was used.

RESULTS

The results of the research showed that during dental caries with a normal level of 25-hydroxy-vitamin D there are no significant changes in the content of Immune Checkpoint Molecules. With the background of deficiency and lack of 25-hydroxy-vitamin D there is a decrease in the amount of B7.2, LAG-3, Tim-3 and PD-1. These changes are being aggravated with an increase of the caries intensity.

CONCLUSION

Vitamin D deficiency leads to a decrease in mucosal immunity of the oral cavity, the multiplication of pathogenic microorganisms, which in turn, releasing various metabolites, including cytokine-like substances, aggravate the pathological process and intensify carious lesions.

Keywords:

dental caries
25-hydroxy-vitamin D deficiency
immune checkpoint molecules

Authors:

Fefelova E.V.

Chita State Medical Academy

Maksimenya M.V.

Chita State Medical Academy

Putneva A.S.

Autonomous non-profit organization Medical Center «XXI Century»

Ushnitsky I.D.

M.K. Ammosov North-Eastern Federal University — Medical Institute»

Mishchenko M.N.

Chita State Medical Academy

Karavaeva T.M.

Chita State Medical Academy

Received:

28.06.2023

Accepted:

19.08.2023

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