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Fefelova E.V.

Chita State Medical Academy

Maksimenya M.V.

Chita State Medical Academy

Putneva A.S.

Autonomous non-profit organization Medical Center «XXI Century»

Ushnitsky I.D.

M.K. Ammosov North-Eastern Federal University — Medical Institute»

Mishchenko M.N.

Chita State Medical Academy

Karavaeva T.M.

Chita State Medical Academy

The effect of vitamin D deficiency on the content of some soluble signaling molecules in the oral fluid in individuals with dental caries

Authors:

Fefelova E.V., Maksimenya M.V., Putneva A.S., Ushnitsky I.D., Mishchenko M.N., Karavaeva T.M.

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Journal: Stomatology. 2024;103(2): 12‑17

DOI: 10.17116/stomat202410302112

Read: 1078 times

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Table of contents

THE EFFECT OF VITAMIN D DEFICIENCY ON THE CONTENT OF SOME SOLUBLE SIGNALING MOLECULES IN THE ORAL FLUID IN INDIVIDUALS WITH DENTAL CARIES
THE EFFECT OF VITAMIN D DEFICIENCY ON THE CONTENT OF SOME SOLUBLE SIGNALING MOLECULES IN THE ORAL FLUID IN INDIVIDUALS WITH DENTAL CARIES

To cite this article:

Fefelova EV, Maksimenya MV, Putneva AS, Ushnitsky ID, Mishchenko MN, Karavaeva TM. The effect of vitamin D deficiency on the content of some soluble signaling molecules in the oral fluid in individuals with dental caries. Stomatology. 2024;103(2):12‑17. (In Russ.)
https://doi.org/10.17116/stomat202410302112

Подписка 2026 Стоматология (Stomatology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

The aim of the sthudy is to sthudy the level of soluble Immune Checkpoint Molecules (B7.2, CTLA-4, Tim-3, Lag-3, PD-1) in the oral fluid during dental caries with the background of a lack and/or deficiency of 25-hydroxy-vitamin D in body.

MATERIALS AND METHODS

During the research 3 groups of people were formed, each one of them included 17 people aged from 20 to 24 years. The first group included students with high-intensity caries (above 9 DMFt index) and 25-hydroxy-vitamin D levels in blood serum >30 ng/ml, the second included students with high caries intensity and 25-hydroxy-vitamin D levels <30 ng/ml. The control group consisted of students with an average DMFt index of 1.5 (from 0 to 3) and a level of 25(OH)D in the blood more than 30 ng/ml. To determine the content of B7.2 (CD86), CTLA-4, Tim-3, Lag-3, PD-1, the Human Vascular Inflammation Panel 1 multiplex analysis kit from Biolegend (USA) was used.

RESULTS

The results of the research showed that during dental caries with a normal level of 25-hydroxy-vitamin D there are no significant changes in the content of Immune Checkpoint Molecules. With the background of deficiency and lack of 25-hydroxy-vitamin D there is a decrease in the amount of B7.2, LAG-3, Tim-3 and PD-1. These changes are being aggravated with an increase of the caries intensity.

CONCLUSION

Vitamin D deficiency leads to a decrease in mucosal immunity of the oral cavity, the multiplication of pathogenic microorganisms, which in turn, releasing various metabolites, including cytokine-like substances, aggravate the pathological process and intensify carious lesions.

Keywords:

dental caries
25-hydroxy-vitamin D deficiency
immune checkpoint molecules

Authors:

Fefelova E.V.

Chita State Medical Academy

Maksimenya M.V.

Chita State Medical Academy

Putneva A.S.

Autonomous non-profit organization Medical Center «XXI Century»

Ushnitsky I.D.

M.K. Ammosov North-Eastern Federal University — Medical Institute»

Mishchenko M.N.

Chita State Medical Academy

Karavaeva T.M.

Chita State Medical Academy

Received:

28.06.2023

Accepted:

19.08.2023

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References:

  1. Talwar M, Borzabadi-Farahani A, Lynch E, Borsboom P, Ruben J. Remineralization of Demineralized Enamel and Dentine Using 3 Dentifrices — An InVitro Study. Dentistry J. 2019;7(3):91.  https://doi.org/10.3390/dj7030091
  2. Bakleicheva MO, Kovaleva IV, Bespalova ON, Kogan IY. The effect of vitamin D on women’s reproductive health. Journal of obstetrics and women's diseases. 2018;67(3):4-19. (In Russ.).] https://doi.org/10.17816/JOWD6734-19
  3. Suplotova LA, Avdeeva VA, Pigarova EA, Rozhinskaja LJa, Troshina EA. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin d deficiency and insufficiency in various geographic regions of the country. Problemy endokrinologii. 2021; 67(2):84-92. (In Russ.). https://doi.org/10.14341/probl12736
  4. Zhou F, Zhou Y, Shi J. The association between serum 25-hydroxyvitamin D levels and dental caries in US adults. Oral Dis. 2020;26(7):1537-1547. https://doi.org/10.1111/odi.13360
  5. Herzog K, Scott JM, Hujoel P, Seminario AL. Association of vitamin D and dental caries in children: Findings from the National Health and Nutrition Examination Survey, 2005-2006. J Am Dent Assoc. 2016;147(6):413-420.  https://doi.org/10.1016/j.adaj.2015.12.013
  6. Kim IJ, Lee HS, Ju HJ, Na JY, Oh HW. A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children. BMC Oral Health. 2018;18(1):43.  https://doi.org/10.1186/s12903-018-0505-7
  7. Pigarova EA, Petrushkina AA. Non-classical effects of vitamin D. Osteoporoz i osteopatii. 2017;20(3):90-101. (In Russ.). https://doi.org/10.14341/osteo2017390-101
  8. Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020;12(7):2097. https://doi.org/10.3390/nu12072097
  9. Szymczak I, Pawliczak R. The Active Metabolite of Vitamin D3 as a Potential Immunomodulator. Scand J Immunol. 2016;83(2):83-91.  https://doi.org/10.1111/sji.12403
  10. Vanherwegen AS, Gysemans C, Mathieu C. Vitamin D endocrinology on the cross-road between immunity and metabolism. Mol Cell Endocrinol. 2017;453:52-67.  https://doi.org/10.1016/j.mce.2017.04.018
  11. De Sousa Linhares A, Leitner J, Grabmeier-Pfistershammer K, Steinberger P. Not All Immune Checkpoints Are Created Equal. Front Immunol. 2018;31;9:1909. https://doi.org/10.3389/fimmu.2018.01909.
  12. Jubel JM, Barbati ZR, Burger C, Wirtz DC, Schildberg FA. The Role of PD-1 in Acute and Chronic Infection. Front Immunol. 2020;24;11:487.  https://doi.org/10.3389/fimmu.2020.00487.
  13. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 2;10(7):e0131539. https://doi.org/10.1371/journal.pone.0131539.
  14. Sharifi A, Vahedi H, Honarvar MR, Alipoor B, Nikniaz Z, Rafiei H, Hosseinzadeh-Attar MJ. Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis. Middle East J Dig Dis. 2019; 11(4):199-204.  https://doi.org/10.15171/mejdd.2019.149
  15. Akbar AN, Henson SM. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? Nat Rev Immunol. 2011;11(4): 289-295.  https://doi.org/10.1038/nri2959
  16. Snopov SA. Mechanisms of vitamin d action on the immune system. Meditsinskaya immunologiya. 2014;16(6):499-530. (In Russ.). https://doi.org/10.15789/1563-0625-2014-6-499-530
  17. Mak A. The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus. Int J Mol Sci. 2018;19(8):2355. https://doi.org/10.3390/ijms19082355
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