Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia

Anisimova N.Y.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0002-3073-7041

Anisimova E.N.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7109-6431

Ryazantcev N.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation

Kravchenko I.A.

Evdokimov Moscow State University of Medicine and Dentistry

Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia

Authors:

Anisimova N.Y., Anisimova E.N., Ryazantcev N.A., Kravchenko I.A.

More about the authors

Journal: Stomatology. 2021;100(5): 25‑29

DOI: 10.17116/stomat202110005125

Downloaded: 35

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Anisimova NY, Anisimova EN, Ryazantcev NA, Kravchenko IA. Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia. Stomatology. 2021;100(5):25‑29. (In Russ.)
https://doi.org/10.17116/stomat202110005125

Close metadata

AIM

To determine the functional diagnostics criteria for predicting the effectiveness of using 2% and 4% solutions articaine without vasoconstrictor and with epinephrine content of 1:200.000.

MATERIAL AND METHODS

The study involved 357 patients (193 women and 164 men) aged 20 to 35 years. with the presence of intact single-rooted and multi-rooted teeth without periodontal pathology without pronounced general somatic pathology, and with a low level of situational anxiety according to the Spielberger-Khanin scale. All the patients received injection anesthesia by the infiltration method of 2% and 4% articaine solution without vasoconstrictor or with epinephrine concentration of 1:200.000. The effectiveness of local anesthesia was assessed by recording functional parameters (electrosensitivity threshold test and hemomicrocirculation) of the pulp of intact single-root and multi-root teeth before anesthesia, 5, 10, 15, 30, and 60 minutes after local anesthesia. The safety of the anesthesia was determined by continuous monitoring of the patient’s hemodynamic parameters: blood pressure, heart rate, blood oxygen saturation before anesthesia and within 60 minutes after.

RESULTS

Articaine solution 2% with epinephrine concentration of 1:200.000 used for infiltration or modified periodontal anesthesia resulted in pulp electrosensitivity threshold growth by 95.93% and 93.58%, respectively. There were no statistically significant differences in hemodynamic values between both study groups.

CONCLUSION

Analysis of the data obtained showed the effectiveness and safe anesthesia with drugs based on 2% articaine with an epinephrine concentration of 1:200.000.

Keywords:

2% and 4% articaine

epinephrine 1:200

000

electric pulp test

infiltration anesthesia

modified periodontal anesthesia

Authors:

Anisimova N.Y.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0002-3073-7041

Anisimova E.N.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7109-6431

Ryazantcev N.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation

Kravchenko I.A.

Evdokimov Moscow State University of Medicine and Dentistry

Received:

19.08.2021

Accepted:

10.09.2021

List of references:

Boyce RA, Kirpalani T, Mohan N. Updates of Topical and Local Anesthesia Agents. Dent Clin North Am. 2016;60(2):445-71. https://doi.org/10.1016/j.cden.2015.12.001
Anisimova EN, Anisimova NYu, Babadzhanyan RS, Gromovik MV. The basis of carrying out of safe local anesthetic in outpatient dental practice. Russian Dental Journal. 2019;23(3-4):144-148. (In Russ.).
Anisimova EN, Ermolyev SN, Pershina LV, Letunova NYu, Orekhova IV. The investigation of the efficacy and safety of the usage 4% solution of articaine with epinephrine concentration. Institute of Dentistry. 2017;1(74):38-40. (In Russ.).
Anisimova EN, Anisimova NYu, Rabinovich SA. Artikain — all pros. Safety and efficacy of using a 4% solution of articaine with various concentrations of epinephrine. New in Dentistry. 2014;6:62-65. (In Russ.).
Anisimova EN, Pershina LV, Ermolyev SN, Orekhova IV, Letunova NYu, Ryazancev NA, Gromovik MV, Lushanin MS, Golikova AM, Erilin EA. The method of periodontal anesthesia during dental treatment. Institute of Dentistry. 2017;3(76):42-48. (In Russ.).
Kämmerer PW, Schneider D, Palarie. Comparison of anesthetic efficacy of 2 and 4% articaine in inferior alveolar nerve block for tooth extraction — a double-blinded randomized clinical trial. Clin Oral Invest. 2017;21:397-403. https://doi.org/10.1007/s00784-016-1804-5
Anisimova EN, Anisimova NYu, Kovylina OS, Kravchenko IA. Assessment of pain and pain relief in children at a dental appointment. Pediatric Dentistry and Prevention. 2020;20(2):101-104. (In Russ.). https://doi.org/10.33925/1683-3031-2019-19-3-56-58
Jakobs W, Ladwig P, Cichon P, Oertel R, Kirch W. Serum levels of articaine 2% and 4% in children. Anesth Prog. 1995;42:113-115. https://pubmed.ncbi.nlm.nih.gov/8934976
Ramadurai N, Gurunathan D, Samuel AV, Subramanian E, Rodrigues SJL. Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial. Clin Oral Investig. 2019;23(9):3543-3550. https://doi.org/10.1007/s00784-018-2775-5
Anisimova EN, Ryazancev NA, Letunova NYu, Orekhova IV, Gromovik MV, Erilin EA, Aksamit LA, Golikova AM, Lushanin MS, Sokhov ST, Goryainov AD. Programma avtomatizirovannogo primeneniya algoritma okazaniya stomatologicheskoj pomoshchi patsientam s soputstvuyushchej patologiej. Svidetel’stvo o gosudarstvennoj registratsii programmy dlya EVM №2017618327. (In Russ.).
Anisimova EN, Voronova YuN, Ermolyev SN, Pershina LV. A method for evaluating local injection anesthesia of the dental pulp. Certificate of state registration No. 2579420 dated 04/10/2016. (In Russ.).

Close metadata