Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia

Anisimova N.Y.; Anisimova E.N.; Ryazantcev N.A.; Kravchenko I.A.

doi:https://doi.org/10.17116/stomat202110005125

Anisimova N.Y.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0002-3073-7041

Anisimova E.N.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7109-6431

Ryazantcev N.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation

Kravchenko I.A.

Evdokimov Moscow State University of Medicine and Dentistry

Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia

Authors:

Anisimova N.Y., Anisimova E.N., Ryazantcev N.A., Kravchenko I.A.

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Journal: Stomatology. 2021;100(5): 25‑29

DOI: 10.17116/stomat202110005125

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To cite this article:

Anisimova NY, Anisimova EN, Ryazantcev NA, Kravchenko IA. Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia. Stomatology. 2021;100(5):25‑29. (In Russ.)
https://doi.org/10.17116/stomat202110005125

Подписка 2026 Стоматология (Stomatology)

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Abstract:

AIM

To determine the functional diagnostics criteria for predicting the effectiveness of using 2% and 4% solutions articaine without vasoconstrictor and with epinephrine content of 1:200.000.

MATERIAL AND METHODS

The study involved 357 patients (193 women and 164 men) aged 20 to 35 years. with the presence of intact single-rooted and multi-rooted teeth without periodontal pathology without pronounced general somatic pathology, and with a low level of situational anxiety according to the Spielberger-Khanin scale. All the patients received injection anesthesia by the infiltration method of 2% and 4% articaine solution without vasoconstrictor or with epinephrine concentration of 1:200.000. The effectiveness of local anesthesia was assessed by recording functional parameters (electrosensitivity threshold test and hemomicrocirculation) of the pulp of intact single-root and multi-root teeth before anesthesia, 5, 10, 15, 30, and 60 minutes after local anesthesia. The safety of the anesthesia was determined by continuous monitoring of the patient’s hemodynamic parameters: blood pressure, heart rate, blood oxygen saturation before anesthesia and within 60 minutes after.

RESULTS

Articaine solution 2% with epinephrine concentration of 1:200.000 used for infiltration or modified periodontal anesthesia resulted in pulp electrosensitivity threshold growth by 95.93% and 93.58%, respectively. There were no statistically significant differences in hemodynamic values between both study groups.

CONCLUSION

Analysis of the data obtained showed the effectiveness and safe anesthesia with drugs based on 2% articaine with an epinephrine concentration of 1:200.000.

Keywords:

2% and 4% articaine

epinephrine 1:200

000

electric pulp test

infiltration anesthesia

modified periodontal anesthesia

Authors:

Anisimova N.Y.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0002-3073-7041

Anisimova E.N.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7109-6431

Ryazantcev N.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation

Kravchenko I.A.

Evdokimov Moscow State University of Medicine and Dentistry

Received:

19.08.2021

Accepted:

10.09.2021

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References:

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