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Gorbunova I.L.

Omsk State Medical Academy, Omsk, Russia

Kravchenko E.N.

Kafedra akusherstva i ginekologii Tsentra povysheniia kvalifikatsii i poslediplomnoĭ podgotovki spetsialistov Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Krivchik G.V.

Omsk State Medical University, Omsk, Russia, 644099

Shestovskikh O.L.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

Lukashevich I.K.

Omsk State Medical University, Omsk, Russia, 644099

Strometskaya N.N.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

Abramyan I.R.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

Age related molecular-genetic preconditions for dental caries in pregnant women

Authors:

Gorbunova I.L., Kravchenko E.N., Krivchik G.V., Shestovskikh O.L., Lukashevich I.K., Strometskaya N.N., Abramyan I.R.

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Journal: Stomatology. 2018;97(2): 27‑31

DOI: 10.17116/stomat201897227-31

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Table of contents

AGE RELATED MOLECULAR-GENETIC PRECONDITIONS FOR DENTAL CARIES IN PREGNANT WOMEN
AGE RELATED MOLECULAR-GENETIC PRECONDITIONS FOR DENTAL CARIES IN PREGNANT WOMEN

To cite this article:

Gorbunova IL, Kravchenko EN, Krivchik GV, Shestovskikh OL, Lukashevich IK, Strometskaya NN, Abramyan IR. Age related molecular-genetic preconditions for dental caries in pregnant women. Stomatology. 2018;97(2):27‑31. (In Russ.)
https://doi.org/10.17116/stomat201897227-31

Подписка 2025-2 (Stomatology)
 
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The aim of the study was to evaluate the allelic polymorphisms kallikrein-4 (KLK-4) gene at the mutant points: G2664153A and G2142A in pregnant women under and over 30 of age. In pregnant women with KLK-4 gene polymorphisms A/A and G/A genotypes the rate of tooth decay growth increases in spite of applying the ternary calcium-phosphate-fluoride-containing gel. This genotype is also associates with unfavorable alteration of such oral fluid indicators as pH, concentrations of inorganic phosphorus, the active concentrations of calcium and potassium, as well as the ratio of total calcium and phosphorus concentrations, the active concentrations of electrolytes, and demineralizing activity of oral fluid.

Keywords:

kallikrein-4 gene
pregnant women
the indicators of oral fluid and oral fluid deposition
intensity of tooth decay growth

Authors:

Gorbunova I.L.

Omsk State Medical Academy, Omsk, Russia

Kravchenko E.N.

Kafedra akusherstva i ginekologii Tsentra povysheniia kvalifikatsii i poslediplomnoĭ podgotovki spetsialistov Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Krivchik G.V.

Omsk State Medical University, Omsk, Russia, 644099

Shestovskikh O.L.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

Lukashevich I.K.

Omsk State Medical University, Omsk, Russia, 644099

Strometskaya N.N.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

Abramyan I.R.

Municipal Clinical Perinatal Center, Omsk, Russia, 644007

List of references:

  1. Bakhmu-dov BR, Bahmudov MB, Alieva ZB. Dynamics of caries affection in pregnant women and assessment of dental care level. Rossiiskii stomatologicheskii zhurnal. 2009;3:27-29. (In Russ.)
  2. Nedoseko VB, Sokolinskaya EG, Lomiashvili LM, Garber OG, Petrova TG. Levels of tooth resistance to tooth decay (conditions of formation, diagnostics, practical significance). Methodological recommendations. Omsk: Izdatelstvo Omskogo medinstituta; 1993. (In Russ.)
  3. Nedoseko VB, Gorbunova IL, Drozdov VA. The problem of caries in terms of tooth decay resistance. Omskii nauchyi vestnik. 2001;16:115-122. (In Russ.)
  4. Drozdov VA, Gorbunova IL, Nedoseko VB. Textural characteristics of tooth enamel and its resistance to tooth decay. Stomatologiya. 2002;4:4-9. (In Russ.)
  5. Tsimbalistov AV, Pihur OL, Frank-Kamenetskaya OV, Golubtsov VV, Plotkina YuV. The results of studying the morphological structure, the chemical composition and the parameters of the dental hard tissues apatites crystalline lattice. Institut stomatologii. 2004;2(23):60-63. (In Russ.)
  6. Gorbunova IL, Drozdov VA, Treni-khin MV, Putintsev SB. Morphological features of the tooth enamel apatites structure in persons with different susceptibility to implementation of dental caries. Problemy stomatologii. 2008;5:5-9. (In Russ.)
  7. Gorbunova IL, Mikheykina NI, Drozdov VA. The morphological structure features of intact tooth enamel in caries-prone and caries-resistant individuals. Sovremennye problemy nauki i obrazovaniya. 2014;6:1027 (In Russ.) www.science-education.ru/120-15682
  8. Gorbunova IL, Mikheikina NI. Elementary composition, morphology and texture of intact enamel teeth in individuals of different age groups. Ural’skii meditsinskii zhurnal. 2014;4(118):89-93.
  9. Gorbunova IL. Molecular-genetic aspects of dental caries implementation. Stomatologiya dlya vsekh. 2006;1:6-9. (In Russ.)
  10. Gorbunova IL. Use of DNA technologies for early detecting susceptibility to dental caries. Stomatologiya. 2006;4:18-19. (In Russ.)
  11. Gorbunova IL. Explanation of the dental diseases genetic marking possibilities. Omskii nauchyi vestnik. 2006;3(37):240-242. (In Russ.)
  12. Denisenko LN, Derevyanchenko SP, Kolesova TV. Stomatological health of pregnant women. Zdorov’e i obrazovanie v XXI veke. 2012;14(2):147. (In Russ.)
  13. Zharkova OA. Prevention of dental diseases during pregnancy. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. 2008;7(4):94-101. (In Russ.)
  14. Simmer JP, Hu Y, Lertlam R, Yamakoshi Y, Hu JC. Hypomaturation Enamel Defects in KLK4 Knockout/LacZ Knockin Mice. J of Biological Chemistry. 2009;284:19110-19121. https://doi.org/10.1074/jbc.M109.013623
  15. Lu Y, Papagerakis P, Yamakoshi Y, Hu JC, Bartlett JD, Simmer JP. Functions of KLK4 and MMP-20 in dental enamel formation. Biol Chem. 2008;389(6):695-700. https://doi.org/10.1515/BC.2008.080
  16. Vavilova TP. Biochemistry of oral cavity tissues and fluids. M.: GEOTAR-Media; 2008. (In Russ.)
  17. Cerný R, Slaby I, Hammarström L, Wurtz T. A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains. J Bone Miner Res. 1996;11(7):883-891. https://doi.org/10.1002/jbmr.5650110703
  18. Vlasov VV. Introduction to Evidence-based Medicine. M.: Media Sfera; 2001. (In Russ.)
  19. Zaks L. Statistical evaluation. M.: Statistika; 1976. (In Russ.)

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