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Kulakov A.A.

Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii Minzdravsotsrazvitiia, Moskva

Grigoryan A.S.

Federal state budgetary institution «Central Research Institute of Stomatology and Maxillofacial Surgery», Russian Ministry of Health, Moscow, Russia

Arkhipov A.V.

FGBU Tsentral'nyĭ NII stomatologii i cheliustno-litsevoĭ khirurgii MZ RF, Moskva

Experimental assessment of biodegradable poliglicolic and polilactic acid polymers for medical use

Authors:

Kulakov A.A., Grigoryan A.S., Arkhipov A.V.

More about the authors

Journal: Stomatology. 2013;92(5): 4‑8

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EXPERIMENTAL ASSESSMENT OF BIODEGRADABLE POLIGLICOLIC AND POLILACTIC ACID POLYMERS FOR MEDICAL USE
EXPERIMENTAL ASSESSMENT OF BIODEGRADABLE POLIGLICOLIC AND POLILACTIC ACID POLYMERS FOR MEDICAL USE

To cite this article:

Kulakov AA, Grigoryan AS, Arkhipov AV. Experimental assessment of biodegradable poliglicolic and polilactic acid polymers for medical use. Stomatology. 2013;92(5):4‑8. (In Russ.)

Подписка 2025-2 (Stomatology)
 
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Interrelations of biodegradable poliglicolic and polilactic acid polymers in various proportions implanted in standardized bone defects were evaluated in animal model with 40 Wister line rats. During 10 month follow-up period bone capsule surrounded all implants, but timing of bone formation and bone quality varied significantly being optimal in LactoSorb group. Destructive features of polymers were also seen in implant-bone contact area defined as inflammation, fibrous tissue formation and cell dystrophy.

Keywords:

bone formation
biodegradable polymers
tissue reaction by implantation

Authors:

Kulakov A.A.

Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii Minzdravsotsrazvitiia, Moskva

Grigoryan A.S.

Federal state budgetary institution «Central Research Institute of Stomatology and Maxillofacial Surgery», Russian Ministry of Health, Moscow, Russia

Arkhipov A.V.

FGBU Tsentral'nyĭ NII stomatologii i cheliustno-litsevoĭ khirurgii MZ RF, Moskva

List of references:

  1. Barber F.A. Resorbable fixation devices: a product guide (Orthopedic special edition) 1998; 4: 1111-1117.
  2. Danials A.U., Chang M.K.O., Adriano K.P., Heller J. Mechanical propertyes of biodegradable polymers and composites, proposed for internal fixation of bone. J. Appl Biomater 1990; 1: 57-980.
  3. Eppley B.L., Morales L., Wood R. Resorbable PLLA-PGA plate and screw fixation in pediatric craniofacial surgery: clinical experience in 1883 patients. Plast Reconstr Surg 2004; 114: 4: 850-857.
  4. Gilding D.K., Reed A.M. Biodegradable polymers - for use in surg/ery - poliglicolic polilacticacid homo and copolymers. Polymer 1979; 20: 1459-1464.
  5. Pietizac W.S., Vestynen B.S., Sarver D.R. Bioresorbable fixation devices: status for the Craniomaxial surgeon. J craniofaxial Surg 1997; 22: 92-66.

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