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Gabidullina R.I.

Kazan State Medical University

Smirnova G.A.

Kazan State Medical University

Ganeeva A.V.

Kazan State Medical University

Valeeva E.V.

Kazan State Medical University

Zaripova A.Sh.

Kazan State Medical University

The relationship of genotypes of the RS2414098 polymorphism of the CYP19A1 gene with the risk of endometrial polyps

Authors:

Gabidullina R.I., Smirnova G.A., Ganeeva A.V., Valeeva E.V., Zaripova A.Sh.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(3): 6‑11

DOI: 10.17116/rosakush2022220316

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Table of contents

THE RELATIONSHIP OF GENOTYPES OF THE RS2414098 POLYMORPHISM OF THE CYP19A1 GENE WITH THE RISK OF ENDOMETRIAL POLYPS
THE RELATIONSHIP OF GENOTYPES OF THE RS2414098 POLYMORPHISM OF THE CYP19A1 GENE WITH THE RISK OF ENDOMETRIAL POLYPS

To cite this article:

Gabidullina RI, Smirnova GA, Ganeeva AV, Valeeva EV, Zaripova ASh. The relationship of genotypes of the RS2414098 polymorphism of the CYP19A1 gene with the risk of endometrial polyps. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(3):6‑11. (In Russ.)
https://doi.org/10.17116/rosakush2022220316

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE OF THE STUDY

To assess the prevalence of alleles and genotypes of the rs2414098 polymorphism of the CYP19A1 gene and investigate their associations with the risk of endometrial polyps.

MATERIAL AND METHODS

The study enrolled 199 female patients of Russian and Tatar nationality from the Republic of Tatarstan. The main group comprised 98 patients with endometrial polyps and the control group comprised 101 patients without endometrial pathology. All the women in the study and control groups had history taking, clinical and laboratory examination, genotyping for single nucleotide polymorphism rs2414098 of CYP19A1 gene by polymerase chain reaction in real time using reagents.

RESULTS

The presence of the C allele and the CC genotype of single-nucleotide polymorphism rs2414098 can be considered as the factors that increase the risk of endometrial polyps in women living in the Republic of Tatarstan. Whereas the presence of the A allele and the AA genotype of this polymorphism reduces the risk of endometrial polyps. The prevalence of alleles and genotypes of rs2414098 of the CYP19A1 gene were comparable with the same in the European population.

CONCLUSION

The study demonstrated the presence of associations of allele C and genotype CC of the single-nucleotide polymorphism rs2414098 of the CYP19A1 gene with the risk of endometrial polyps.

Keywords:

endometrial polyps
single-nucleotide polymorphism
CYP19A1
alleles
genotypes

Authors:

Gabidullina R.I.

Kazan State Medical University

Smirnova G.A.

Kazan State Medical University

Ganeeva A.V.

Kazan State Medical University

Valeeva E.V.

Kazan State Medical University

Zaripova A.Sh.

Kazan State Medical University

Received:

26.01.2022

Accepted:

09.02.2022

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References:

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