Aim — to investigate the role of cytokines in the pathogenesis of threatened abortion in multiparous women and assessing the role of immunomodulation effect of panavir in these patients. Material and methods. We examined 120 multiparous (more than four deliveries) at the age of 29—40 with threatened abortion of current pregnancy. Primary group consisted of 70 multiparous women who received antiviral immunomodulating drug panavir as a part of the complex treatment of threatened abortion. Fifty multiparous pregnant women comprised the comparison group. Control group consisted of 50 almost healthy multiparous women with normal pregnancy. Cytokine system research in the second and third trimesters included determination of TNF-α and interleukins IL-1β, IL-6, IL-4, IL-10, IL-1, and IL-2 levels using enzyme immunoassay with mouse monoclonal antibodies. Results. In pregnant women of primary and comparison groups we found increased levels of pro-inflammatory cytokines (IL-1, IL-2, IL-1 β, IL-6, TNF-α) and decreased blood levels of anti-inflammatory cytokines (IL-4, IL-10) compared to these levels in control group on admission. This indicates deeply impaired implantation and placentation associated with predominance of T-helpers type 1, which produce pro-inflammatory cytokines, in decidual and chorial tissues. Inclusion of panavir in traditional pregnancy continuation treatment significantly raised the levels of anti-inflammatory cytokines, which are produced by T-helpers type 2, which contributed to pregnancy continuation. Conclusion. Conclusion results of this study indicate feasibility of panavir inclusion in traditional treatment of multiparous women with threatened abortion of current pregnancy as an immunomodulating drug.