The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Local inflammation as a component of emergency spontaneous labor

Authors:

Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A., Trunov A.N.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2018;18(3): 13‑19

DOI: 10.17116/rosakush201818313-19

Views: 1926

Downloaded: 19

Download PDF (RU)
Contact the author
Table of contents

LOCAL INFLAMMATION AS A COMPONENT OF EMERGENCY SPONTANEOUS LABOR
LOCAL INFLAMMATION AS A COMPONENT OF EMERGENCY SPONTANEOUS LABOR

To cite this article:

Shcherbakov VI, Ryabichenko TI, Skosyreva GA, Trunov AN. Local inflammation as a component of emergency spontaneous labor. Russian Bulletin of Obstetrician-Gynecologist. 2018;18(3):13‑19. (In Russ.)
https://doi.org/10.17116/rosakush201818313-19

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Pecu­liarities of local mRNA gene expression of pro- and anti-inflammatory cyto­kines in term pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):6-13
The problem of diabetes mellitus in obstetrics. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):25-29
Rela­tionship between pregnancy and the risk of mali­gnant neoplasms of the female reproductive system. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):48-54
Asse­ssment of the effe­ctiveness of compression therapy in pregnant women with geni­tal vari­cose veins. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):60-65
Expe­rience of combined treatment of patients with infe­rtility operated for exte­rnal geni­tal endo­metriosis. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):77-81
Clinical obse­rvation of successful pregnancy and deli­very of patients with giant placental chorioangioma. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):103-107
Predictors of success of in vitro fertilization with cryotransfer in patients with chro­nic endo­metritis acco­rding to laser conversion testing. Russian Journal of Human Reproduction. 2024;(2):62-73
Hemo­rrhagic stroke during pregnancy as a result of rupture of cave­rnous malformation. Clinical case. Russian Journal of Human Reproduction. 2024;(2):90-95
Inte­rleukin-6 as a marker of infe­ction gene­ralization in neonatal sepsis. Russian Journal of Anesthesiology and Reanimatology. 2024;(3):35-42
Sleep diso­rders during pregnancy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5-2):99-104

This review presents new data on the mechanisms of spontaneous labor at term. It becomes apparent from present-day perspectives that the inflammatory process is an important component of this labor. The biological significance of inflammation is to attract immune cells to the uterus and its components, such as the myometrium, endometrium and cervix. Myometrium-secreted mediators and migratory cells, such as monocytes, neutrophils, and T-lymphocytes, perform many functions necessary for normal labor and delivery. In particular, they enhance the contractile activity of the myometrium and increase the expression of oxytocin receptors and the synthesis of prostaglandins. The role of endogenous ligands in labor induction is shown using emergency and premature labor as an example. Considering labor and delivery in the context of inflammation, it can be stated that these data are important for a deeper understanding of the mechanism of labor induction and expand the concept of inflammation.

Keywords:

labor
delivery
inflammation
cytokines
pregnancy
uterus

Authors:

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

List of references:

  1. Thompson AJ, Telfer JF, Young A, Campbell S, Stewart CJR, Cameron IT, Greer IA, Norman JE. Leucocytes infiltrate the myometrium during human parturition: further evidence that labor is an inflammatory process. Hum Reprod. 1999.14:1:229-236. https://doi.org/10.1093/humrep/14.1.229
  2. Gomes-Lopez N, Derek Stlouis, Marcus Alehr, Elly Sanchez-Rodriguez, Marcia Arenas-Hernandez. Immune cells in term and preterm labor. Cellular Molecular Immunology. 2014;11:6:571-581. https://doi.org/10.1039/cmi.2014.46
  3. Gomez Lopez N, Romero R, Plazyo O, Panaitescu B, Furcron AE, Miller D, Roumayah T, Flom E, Hassan SS. Intra-amniotic administration of HMGB-1 induced spontaneous preterm labor and birth. Amer J Reprod Immunol. 2016;75:1:3-7. https://doi.org/10.1111/aji.12443
  4. Osman I, Young A, Ledingham MA, Thompson AJ, Jordan F, Greer IA, Norman JE. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labor at term. Mol Hum Reprod. 2003;9:1:41-45. https://doi.org/10.1093/molehr/gagoo1
  5. Sivarajasingam SR, Imami N, Johnson MR. Myometrial cytokines and their role in the onset of labour. J Endocrinol. 2016;231: 3:R101-R119. https://doi.org/10.1530/JOE-16-0157
  6. Xu C, Liu W, You X, Leimert K, Popowyc ZK, Fang X, Wood SL, Slater DM, Sun Z, Gu H, Olson DM, Ni X. PGF2ɑ modulates the output of chemokines and pro-inflammatory cytokines in myometrial cells from term pregnant women through divergent signaling pathways. Mol Hum Reprod. 2015;21:7:603-614. https://doi.org/10.1093/molehr/gav018
  7. Hutchinson JL, Rajagopal SP, Yuan M, Norman JE. Lipopolysaccharide promotes contration of uterine myocytes via activation of RHO/ROCK signaling pathways. FASEB J. 2014;28:1:94-105. https://doi.org/10/1096/fj.13-237040
  8. Srikhajon K, Shynlova O, Preechapornprasert A, Chanrachakul B, Lye S. A new role for monocytes in modulating myometrial inflammation during human labor. Biol Reprod. 2014;91:1:10-21. https://doi.org/10.1095/biolreprod.113.114975
  9. Lee YH, Shynlova O, Lye SJ. Stretch-induced human myometrial cytokines enhance immune cell recruit-ment via endothelial activation. Cell Mol Immunol. 2015;12:2:231-242. https://doi.org/10.1038/cmi.2014.39
  10. Shcherbacov VI, Pozdnyakov IM, Shirinskaya AV, Volkov MV. The levels of interleukin-6, soluble interleukin-6 and vascular endothelial growth factor receptors during delivery at term, threatened preterm labor and in preeclampsia. Akusherstvo i ginekologiya. 2017;3:50-54. (In Russ.) https://doi.org/10.18565/oig.2017.3.50-4
  11. White GE, Igbal AJ, Greaves DR. CC chemokine receptors and chronic inflammation — therapeutic opportunities and pharmacological challenges. Pharmacol Rev. 2013;65:1:47-89. https://doi.org/10.1124/pr.11.005074
  12. Young A, Thompson AJ, Ledingham M, Jordan F, Greer IA, Norman JE. Immunolocalization of proinflammatori cytokines in myometrium, cervix and fetal membranes during human parturition at term. Biol Reprod. 2002;66:2:445-449.
  13. Myers DA. The recruitment and activation of leukocytes into the immune cervix: further support that cervical remodeling involves an immune inflammatory mechanism. Biol Reprod. 2012;87:5:107-110. https://doi.org/10.1095/biolreprod.112.105049
  14. Belt AR, Baldassare JJ, Molnar M, Romero R, Hertelendy F. The nuclear transcription factor NF-κB mediates interleukin-1 beta induced expression of cyclooxygenase-2 in human myometrial cell. Amer J Obstet Gynecol. 1999;181:2:359-366.
  15. Aoki T, Narumiya S. Prostaglandins and chronic inflammation. Trend in Pharmacol Sci. 2012;33:6:304-311. https://doi.org/10.1016/j.tips2012.02.004
  16. Khatun S, Kanayama N, Belayet H, Yonezawa M, Kobayashi T, Terao T. Interleukin-8 potentiates the effect of interleykin-1 induced uterine contactions. Hum Reprod. 1999;14:2:560-565.
  17. Tribe RM. Interleukin-1 induced calcium trainsients and enchances basal and store operated calcium entry in human myometrial smooth muscle. Biol Reprod. 2002;68:5:1842-1849.
  18. Chapman NR, Smyrnias I, Anumba D, Europa-Finner GN, Robson SC. Expression of the GTR-binding protein is repressed by the nuclear factor κB Rel. A subunit in human myometrium. Endocrinology. 2005;146:11:4994-5002.
  19. Rajagopal SP, Hutchinson JL, Dorward DA, Rossi AG, Norman JE. Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocite contraction, with effects opposed by progesterone. Mol Hum Reprod. 2015;21:8:172-186. https://doi.org/10.1093/molehr/gav027
  20. Messina S, Mazzeo A, Bitto A, Aquennouz M, Migliorato A, de Pasquale MG, Minutoli L, Altavilla D, Zentalin L, Ciacca M, Squadrito F, Vita G. VEGF overexpression via cedeno-associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function mdx mice. FASEB J. 2007;21:13:3737-3746. https://doi.org/10.1096/fj.07-8459cjm
  21. Sadowsky D, Novy M, Witkin S, Gravett M. Dexamethasone or interleukin-10 blocks interleukin-1 beta-induced uterine contractions in pregnant rhesus monkeys. Amer J Obstet Gynecol. 2003;188:1:252-263.
  22. Hutchings G, Williams O, Cretoiu SM, Ciontea SM. Myometrial interstitial cells and the coordination of myometrial contractility. J Cellular Molec Med. 2009;13:10:4268-4282. https://doi.org/10.1111/j.1582-4934.2009.00894
  23. Zhelezova ME, Maltseva LI, Zefirova TP. Accelerated labor from the standpoint of evaluation of health and disease. Akusherstvo i ginekologiya. 2016;11:64-70. (In Russ.) https://doi.org/10.18565/aig.2016.11.64-70
  24. Elliott CL, Loudon JAZ, Brown N, Slater DM, Bennett PR, Sullivan MH. IL-1beta and IL-8 in human fetal membranes changes with gestational age, labor and culture conditions. Amer J Reprod Immunol. 2001;46:4:260-267.
  25. Karimova GN, Muravyeva VV, Priputnevich TV, Shmakov KG. Role of the microflora from the cervical canal of puerperal women in the early puerperium in the development of postpartum endometritis. Akusherstvo i ginekologiya. 2016;11:71-78. (In Russ.) https://doi.org/10.18565/aig.2016.11/71-8
  26. You X, Liu J, Xu C, Liu W, Zhu X, Li Y, Sun O, Gu H, Ni X. Corticotropin-relising hormone (CRH) promotes inflammation in human pregnant myometrium: the evidence of CRH initiating parturition. J Clin Endocrinol Metabol. 2014;99:2:199-208. https://doi.org/10.7210/vc.2013-3366
  27. Xu C, You X, Liu W, Sun O, Ding X, Huang Y, Ni X. Prostaglandin F2ɑ regulates the expression of uterine activation proteins via multiple signating pahways. Reprod Sci. 2015;149:139-146. https://doi.org/10.1530/REP-14-0479
  28. Alexander HA, Sooranna SR, Myatt H, Johnson MR. Myometrial tumor necrosis factor-alpha receptors increase with gestation and labor and modulate gene expression through mitogen-activated kinase and nuclear factor-kappa B. Reprod Sci. 2012;19:1:43-54. https://doi.org/10.1177/1933719111413297
  29. Correa RG, Milutinovic S, Reed JC. Roles of NOD-1 (NLRC1) and NOD-2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep. 2012;32:597-608. https://doi.org/10.1042/BSR2012.0055
  30. Kawai T, Akira S. The roles of RLRs, KLRs and NLR in pathogen recognition. Internat Immunol. 2009;21:4:317-337. https://doi.org/10.1093/intimm/dxpo17
  31. Lappas M. NOD 1 and NOD 2 regulate proinflammatory and prolabor mediators in human fetal membranes and myometrium via nuclear factor-kappa B. Biol Reprod. 2013;89:1:14-27. https://doi.org/10.1095/biolreprod.113.110056
  32. Di Virgilio F. The therapeutic potential of modifying inflammasomes and NOD-like receptors. Pharmacol Rev. 2013;65:3:872-905. https://doi.org/10.114.pz.112.006171
  33. Hamilton S, Oomomiam Y, Stepen G, Shynlova O, Tower CL, Garrod A, Lye SJ, Jones RL. Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor. Biol Reprod. 2012;86:2:39-41. https://doi.org/10.1095/bidreprod.095505
  34. Kurchakova TA, Tyutyunnik VL, Kan NE, Medzhidova MK, Sirotkina EA. Pro- and antioxidant system in preterm birth. Akusherstvo i ginekologiya. 2016;5:20-24. (In Russ.) https://doi.org/10.18565/aig.2016.5.20-24
  35. Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y. NOD-1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. Experim Med. 2006;203:3:203-213. https://doi.org/10.1084/jem20051229
  36. Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y. An essential role for NOD-1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003;4:7:702-707.
  37. Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O’Leary JJ, O’Neill LAJ. TLR-9 provokes inflammation in response to fetal DNA mechanism for fetal loss in preterm birth and preeclampsia. J Immunol. 2012;188: 11:5706-5712. https://doi.org/10.4049/jimmunol.1103454
  38. Romero, Miranda J, Chaiworapongsce T, Korzeninieski SJ, Gotsch F, Dong Z, Ahmed AI, Yoon BH, Hassan SS, Kim CJ, Yeo L. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72:5:458-474. https://doi.org/10.1111/aji.12296
  39. Medzhidova MK, Tyutyunnik VL, Kan NE, Kurchakova TA, Kokoeva DN. The role of systemic inflammatory response syndrome in preterm labor development. Problemy reproduktsii. 2016;22:2:116-120. (In Russ.) https://doi.org/10/17116/repro.2016222116-120
  40. Alotaibi M, Arrowsmith S, Wray S. Hypoxia-induced force increase (HIF-1) is a novel mechanism underlying the strengthening of labor contractions, produced by hypoxic stresses. PNAS. 2015;112:31:8763-9768. https://doi.org/1073/pnas.1503497112
  41. Miyoshi H, Yamaoka K, Urabe S, Kudo Y. ATP-induced current carried through P2X7 receptor in rat myometrial cells. Reprod Sci. 2012;19:12:1285-1291. https://doi.org/10.1177/1933719112450333
  42. Eltzschig HK, Eckle T. Ischemia and reperfusion from mechanism to translation. Nat Med. 2011;17:11:1391-1401. https://doi.org/10.1038/nm.2507
  43. Shynlova O, Tsui P, Dorogin A, Lye SJ. Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. J Immunol. 2008;181:2:1470-1479. https://doi.org/10.4049/jimmunol.181.2.1470
  44. Shynlova O, Lee YH, Srikhajon K, Lye S. Physiologic uterine inflammation and labor onset integration of endocrine and mechanical signals. Reprod Sci. 2013;20:2:154-167. https://doi.org/10.1177/1933719112446084
  45. Shcherbakov VI, Ryabichenko TI, Skosyreva GA, Trunov AN. The role of local inflammation in the ovulation and implantation. Tsitokiny i vospalenie. 2014;13:4:16-22. (In Russ.)
  46. Frolova OG, Shuvalova MP, Guseva EV, Ryabinkina IN. Maternal mortality at the present stage of development of the healthcare system. Akusherstvo i ginekologiya. 2016;12:121-124. (In Russ.) https://doi.org/10.18565/aig.2016.12.121-4

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.