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Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Local inflammation as a component of emergency spontaneous labor

Authors:

Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A., Trunov A.N.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2018;18(3): 13‑19

DOI: 10.17116/rosakush201818313-19

Read: 2286 times

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Table of contents

LOCAL INFLAMMATION AS A COMPONENT OF EMERGENCY SPONTANEOUS LABOR
LOCAL INFLAMMATION AS A COMPONENT OF EMERGENCY SPONTANEOUS LABOR

To cite this article:

Shcherbakov VI, Ryabichenko TI, Skosyreva GA, Trunov AN. Local inflammation as a component of emergency spontaneous labor. Russian Bulletin of Obstetrician-Gynecologist. 2018;18(3):13‑19. (In Russ.)
https://doi.org/10.17116/rosakush201818313-19

 
Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
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Abstract:

This review presents new data on the mechanisms of spontaneous labor at term. It becomes apparent from present-day perspectives that the inflammatory process is an important component of this labor. The biological significance of inflammation is to attract immune cells to the uterus and its components, such as the myometrium, endometrium and cervix. Myometrium-secreted mediators and migratory cells, such as monocytes, neutrophils, and T-lymphocytes, perform many functions necessary for normal labor and delivery. In particular, they enhance the contractile activity of the myometrium and increase the expression of oxytocin receptors and the synthesis of prostaglandins. The role of endogenous ligands in labor induction is shown using emergency and premature labor as an example. Considering labor and delivery in the context of inflammation, it can be stated that these data are important for a deeper understanding of the mechanism of labor induction and expand the concept of inflammation.

Keywords:

labor
delivery
inflammation
cytokines
pregnancy
uterus

Authors:

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

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