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Krasnopol'skaia I.V.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Popov A.A.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Gorina N.V.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia

Kareva E.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia

Balan V.E.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Gene expression of collagen metabolic proteins in the paraurethral connective tissue of women with urinary incontinence and small pelvic organ prolapse

Authors:

Krasnopol'skaia I.V., Popov A.A., Gorina N.V., Kareva E.N., Balan V.E.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2015;15(6): 36‑41

DOI: 10.17116/rosakush201515636-41

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Table of contents

GENE EXPRESSION OF COLLAGEN METABOLIC PROTEINS IN THE PARAURETHRAL CONNECTIVE TISSUE OF WOMEN WITH URINARY INCONTINENCE AND SMALL PELVIC ORGAN PROLAPSE
GENE EXPRESSION OF COLLAGEN METABOLIC PROTEINS IN THE PARAURETHRAL CONNECTIVE TISSUE OF WOMEN WITH URINARY INCONTINENCE AND SMALL PELVIC ORGAN PROLAPSE

To cite this article:

Krasnopol'skaia IV, Popov AA, Gorina NV, Kareva EN, Balan VE. Gene expression of collagen metabolic proteins in the paraurethral connective tissue of women with urinary incontinence and small pelvic organ prolapse. Russian Bulletin of Obstetrician-Gynecologist. 2015;15(6):36‑41. (In Russ.)
https://doi.org/10.17116/rosakush201515636-41

 
Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
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Abstract:

Objective — to reveal a role of the expression of collagen metabolic proteins in paraurethral connective tissue in the development of urinary incontinence and small pelvic organ prolapse. Subjects and methods. Twenty-six patients aged 26 to 51 patients, among them there were 9 patients without urinary incontinence and small pelvic organ prolapse (a control group), 9 with stress urinary incontinence, and 9 with small pelvic organ prolapse (study groups), were examined. Matrix ribonucleic acid was isolated from paraurethral connective tissue biopsy specimens. The gene expression level of types III and I collagen, matrix metalloproteinases (MMP-2 and MMP-9), and proteoglycan decorin were investigated. Results. Increased type III collagen disintegration was ascertained to play a key role in the development of urinary incontinence due to the enhanced expression of MMP-9 and its replacement by type I collagen. Prolapse development was to a greater extent caused by the disintegration of collagens, which was attended by their imbalance, namely, by a greater decrease in type I collagen. Conclusion. Urinary incontinence and small pelvic organ prolapse are mainly characterized by unidirectional and differently marked connective tissue metabolic disturbances, making it possible to outline ways to search for pharmaceutical drugs that may be useful for the adjuvant therapy (prevention) of the above-mentioned diseases. The authors declare no conflicts of interest.

Keywords:

small pelvic organ prolapse
urinary incontinence
paraurethral connective tissue
gene expression of collagen metabolic proteins

Authors:

Krasnopol'skaia I.V.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Popov A.A.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Gorina N.V.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia

Kareva E.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia

Balan V.E.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

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