Female central hypogonadism may be a cause of persistent amenorrhea and hypoestrogenemia. Objective — to make a complex assessment of clinical, hormonal, and biochemical parameters in young women with central hypogonadism and to study the signs of premature aging. Subject and methods. A total of 161 young women aged 24.9 (21.2—30.5) years with central hypogonadism, including 76 patients with isolated hypogonadism and 85 with hypogonadism associated with other types of pituitary failure, 53 healthy reproductive-aged women aged 23.9 (23.1—28.0) years, and 50 healthy middle-aged and elderly women aged 56 (53—58) years who were postmenopausal were examined. Results. In the young women with central hypogonadism, the rate of neurosplanchnic and psychoemotional disorders, and urogenital complaints was significantly higher than that in the healthy women of the same age, but at the same time it was comparable with that in the postmenopausal women. The concentrations of estradiol, testosterone, and dehydroepiandrosterone were also statistically lower than those in the healthy young women and were not substantially different from those in middle-aged and elderly women who were postmenopausal. Hypercholesterolemia, hypertriglyceridemia, and elevated bone metabolic markers, which were detected in central hypogonadism, were also uncharacteristic of the healthy women of the same age, but were observed in the middle-aged and elderly women who were postmenopausal. Conclusion. According to clinical symptoms and hormonal and biochemical parameters, the status of the young women with central hypogonadism was comparable with that of the middle-aged and elderly women who were postmenopausal, suggesting the premature aging phenomenon in the presence of female central hypogonadism. The authors declare no conflicts of interest.