Effect of microdose combined oral contraceptives on the serum levels of macroglobulin family proteins and their IgG immunocomplexes

Keremetskaia E.V.

Kafedra akusherstva i ginekologii

Bazhenova L.G.

Kafedra akusherstva i ginekologii

Zorina R.M.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Zorina V.N.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Effect of microdose combined oral contraceptives on the serum levels of macroglobulin family proteins and their IgG immunocomplexes

Authors:

Keremetskaia E.V., Bazhenova L.G., Zorina R.M., Zorina V.N.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2012;12(2): 36‑40

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To cite this article:

Keremetskaia EV, Bazhenova LG, Zorina RM, Zorina VN. Effect of microdose combined oral contraceptives on the serum levels of macroglobulin family proteins and their IgG immunocomplexes. Russian Bulletin of Obstetrician-Gynecologist. 2012;12(2):36‑40. (In Russ.)

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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The investigation was undertaken to study the effect of microdose combined oral contraceptives (COC) on the serum levels of α2-macroglobulin (α2-MG), pregnancy-associated α2-glycoprotein (α2-PAG) and their immunocomplexes (α2-MG-IgG and α2-PAG-IgG). Twenty-four reproductive-age patients using COC for contraception during a year were examined over time. The authors estimated the serum levels of α2-MG and α2-PAG by quantitative rocket immunoelectrophoresis and those of immune complexes by enzyme immunoassay. During a year, the serum level of α2-PAG was found to be increased by 20.6 times in 83.3% of the women using a contraceptive containing 20 µg ethinyl estradiol and 150 µg desogestrel (Group 1) and by an average of 14 times in only 41.7% of those using an agent containing 20 µg ethinyl estradiol and 100 µg levonorgestrel (Group 2). There was a dynamic reduction in the blood immunocomplexes in Group 1 women and an increase in the α2-PAG-IgG complexes in Group 2 patients.

Keywords:

microdose combined oral contraceptives

pregnancy-associated α2-glycoprotein

α2-macroglobulin

serum levels

Authors:

Keremetskaia E.V.

Kafedra akusherstva i ginekologii

Bazhenova L.G.

Kafedra akusherstva i ginekologii

Zorina R.M.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Zorina V.N.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

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