Thirty women (9 patients with bacterial vaginosis; 9 with Candida vulvovaginitis, and 12 with nonspecific vulvovaginitis) receiving the probiotic vagilac in the first trimester of pregnancy to recover the normal vaginal microflora were examined. Vagilac was found to have a significant positive effect on vaginal microbiocenosis to prevent an increase in pH values, thereby improving the pregnant women's general condition. Inclusion of vagilac into a package of measures after antibacterial therapy for nonspecific vaginitis, Candida vulvovaginitis, and bacterial vaginosis in pregnant women in the first trimester caused an increase in the population of bifido-, and lactoflora in particular, a reduction in the degree of colonization until opportunistic bacteria were completely eliminated, and aided in decreasing the incidence of enteric disbacteriosis in women at risk for infectious and inflammatory diseases.