The progress in the improvement of the methods for the stomatological treatment with the application of the implantological techniques depends not only on the recent advancements in the design and the construction of titanium dental implants but also on the physical and chemical properties of their surface and changes thereof. A clinical observational prospective study covering the 5 year period from 20913 till 2017 was carried out that involved a cohort of constant composition comprising 300 patients. The primary objective of the study was to obtain information about the outcomes of the application of dental implants the surface of which had been modified with the use of the atomic-layer deposition technique for anatase-structured titanium oxide (as exemplified by the conmet implantation system). Each clinical case was considered to be a single unit of observation irrespective of the number of the used implants with the modified biologically active surface. Moreover, the archival materials containing the results of application of the dental implants having no modified biologically active surface were available for the purpose of comparative analysis. The results of the present study give reason to draw the following conclusions: first, the modified surface of the anatase-structured titanium oxide implants markedly improves their biocompatibility to the level necessary for the manifestation of the biological activity; second, the biologically active surface enhances the biocompatibility of implants to the bone tissue of different density. As a result, the application of the dental implants having the modified biologically active surfaces has beneficial effect on the qualitative and quantitative characteristics of reparative contact osteogenesis, improves clinical signs and symptoms as well as the outcomes of the treatment, enhances the probability of the favourable prognosis of the stomagtological treatment with the use of dental implants. The overall effectiveness of the application of the dental implants having the modified biologically active surfaces amounted, in the present study, to 98.5% in comparison with less than 95% in the patients treated with the use of dental implants having the unmodified surface.