The fixing properties of 2-cyanoacrylic acid ethyl ester-based medical glue and the morphological results of its use for reimplantation of septal cartilage (experimental study)

Sergeeva N.V.; Rusetskiĭ Iu.Iu.; Svistushkin V.M.; Demura T.A.; Sobolev V.P.; Spiranskaya O.A.

doi:https://doi.org/10.17116/rosrino20192702170

Sergeeva N.V.

ENT-Department Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia, 119991

Rusetskiĭ Iu.Iu.

Kafedra bolezneĭ ukha, gorla i nosa Pervogo MGMU im. I.M. Sechenova Minzdravsotsrazvitiia Rossii, Moskva

SPIN RSCI: 1344-6230
Scopus AuthorID: 57193898668

Svistushkin V.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

Demura T.A.

Kafedra patologicheskoĭ anatomii im. I.M. Strukova Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Sobolev V.P.

Kafedra bolezneĭ ukha, gorla i nosa Pervogo MGMU im. I.M. Sechenova Minzdravsotsrazvitiia Rossii, Moskva

Spiranskaya O.A.

National Research and Practical Centre of Children’s Health, Ministry of Health of the Russian Federation, Moscow, Russia, 119991

The fixing properties of 2-cyanoacrylic acid ethyl ester-based medical glue and the morphological results of its use for reimplantation of septal cartilage (experimental study)

Authors:

Sergeeva N.V., Rusetskiĭ Iu.Iu., Svistushkin V.M., Demura T.A., Sobolev V.P., Spiranskaya O.A.

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Journal: Russian Rhinology. 2019;27(2): 70‑76

DOI: 10.17116/rosrino20192702170

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Sergeeva NV, Rusetskiĭ IuIu, Svistushkin VM, Demura TA, Sobolev VP, Spiranskaya OA. The fixing properties of 2-cyanoacrylic acid ethyl ester-based medical glue and the morphological results of its use for reimplantation of septal cartilage (experimental study). Russian Rhinology. 2019;27(2):70‑76. (In Russ.)
https://doi.org/10.17116/rosrino20192702170

Подписка 2026 Российская ринология (Russian Rhinology)

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Abstract:

Introduction. Adhesive fixation of nasal septum tissues after septoplasty is one of the modern alternatives to nasal packing. Purpose. To determine the adhesive features of the medical bioadhesive sulfacrylate, and to assess the morphological and physiological features of exposed tissues, using an in vivo animal model. Material and methods. 18 rabbits were divided into two groups, 9 animals in each group. During septoplasty, a cartilage autograft was affixed to mucoperichondrium with the bioadhesive sulfacrylate in the main group. An autograft was implanted without adhesive in the control group. Each test subject from the study was examined at 7 days, 1 month and 3 months after the operation. Adhesive features of the biological glue were studied, and a histologic analysis of the implantation site was carried out. Results. 2-cyanoacrylic acid ethyl ester-based bioadhesive provides superior fixation of cartilage autograft in the animal model without evidence of tissue toxicity. Conclusion. sulfacrylate bioadhesive can be considered as an option for tissue fixation in septoplasty.

Keywords:

septoplasty

nasal septum

cyanoacrylate-based glue

adhesive fixation

Authors:

Sergeeva N.V.

Rusetskiĭ Iu.Iu.

Kafedra bolezneĭ ukha, gorla i nosa Pervogo MGMU im. I.M. Sechenova Minzdravsotsrazvitiia Rossii, Moskva

SPIN RSCI: 1344-6230
Scopus AuthorID: 57193898668

Svistushkin V.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

Demura T.A.

Kafedra patologicheskoĭ anatomii im. I.M. Strukova Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Sobolev V.P.

Kafedra bolezneĭ ukha, gorla i nosa Pervogo MGMU im. I.M. Sechenova Minzdravsotsrazvitiia Rossii, Moskva

Spiranskaya O.A.

National Research and Practical Centre of Children’s Health, Ministry of Health of the Russian Federation, Moscow, Russia, 119991

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