Роль адипозопатии в развитии ассоциированных с ожирением заболеваний

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Ожирение связано с развитием многих ассоциированных с ним заболеваний, однако механизмы, ведущие к их появлению, ясны не до конца.

ЦЕЛЬ ОБЗОРА

Проанализировать роль адипозопатии в механизме развития ассоциированных с ожирением заболеваний.

МАТЕРИАЛЫ И МЕТОДЫ

Поиск опубликованных данных проведен в электронных базах данных MedLine (PubMed) и eLibrary.

РЕЗУЛЬТАТЫ

Теория увеличения жировой ткани утверждает, что происходит увеличение не абсолютного количества клеток жировой ткани, а их способности накапливать липиды и тем самым влиять на метаболический гомеостаз. При превышении предела расширяемости жировой ткани происходят миграция и осаждение липидов в других органах. Эктопическое накопление липидов вызывает липотоксические эффекты, приводя к развитию метаболических заболеваний. В данном обзоре рассматриваются возможные механизмы нарушения расширяемости жировой ткани и примеры заболеваний, подтверждающие данную теорию.

ЗАКЛЮЧЕНИЕ

Адаптация программы снижения массы тела, направленная на улучшение метаболических показателей индивидуума, а не на общие значения, основанные на популяционных исследованиях, может привести к более успешному лечению ожирения и метаболических заболеваний.

Ключевые слова:

теория увеличения жировой ткани

адипоцитарная дисфункция

липолиз

липотоксичность

Авторы:

Ким О.Т.

ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России

ORCID: 0000-0002-0332-7696

Дадаева В.А.

ORCID: 0000-0002-0348-4480

Лебедева Д.И.

ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России

ORCID: 0000-0003-2478-9619

Драпкина О.М.

ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России;
ФГБОУ ВО «Российский университет медицины» Минздрава России

SPIN РИНЦ: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Дата поступления:

27.09.2024

Дата принятия в печать:

25.10.2024

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