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Kim O.T.

National Medical Research Center for Therapy and Preventive Medicine

Dadaeva V.A.

National Medical Research Center for Therapy and Preventive Medicine

Lebedeva D.I.

Tyumen State Medical University

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
Russian University of Medicine

The role of adiposopathy in the development of obesity-related diseases

Authors:

Kim O.T., Dadaeva V.A., Lebedeva D.I., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(2): 96‑102

DOI: 10.17116/profmed20252802196

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Table of contents

THE ROLE OF ADIPOSOPATHY IN THE DEVELOPMENT OF OBESITY-RELATED DISEASES
THE ROLE OF ADIPOSOPATHY IN THE DEVELOPMENT OF OBESITY-RELATED DISEASES

To cite this article:

Kim OT, Dadaeva VA, Lebedeva DI, Drapkina OM. The role of adiposopathy in the development of obesity-related diseases. Russian Journal of Preventive Medicine. 2025;28(2):96‑102. (In Russ.)
https://doi.org/10.17116/profmed20252802196

 
 
 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

Obesity is associated with many related diseases. However, the mechanisms of their occurrence are still not clear.

PURPOSE OF THE REVIEW

To analyze the role of adipozopathy in the mechanism of developing obesity-related diseases.

MATERIALS AND METHODS

The search for published data was made in the MedLine (PubMed) and eLibrary databases.

RESULTS

An adipose tissue growth theory suggests that adipose tissue expansion is not due to an increase in absolute number of adipose tissue cells but their growing ability to accumulate lipids and thus influence the metabolic homoeostasis. When the adipose tissue expansion limit is achieved, the lipids migrate and deposit in other organs. Ectopic accumulation of lipids causes lipotoxic effects resulting in metabolic diseases. This review discusses possible mechanisms of adipose tissue expansion disorders and examples of diseases that confirm this theory.

CONCLUSION

A weight loss program adaptation to improve an individual’s metabolic indices instead of general values based on population studies may result in more successful treatment of obesity and metabolic diseases.

Keywords:

adipose tissue growth theory
adipocyte dysfunction
lipolysis
lipotoxicity

Authors:

Kim O.T.

National Medical Research Center for Therapy and Preventive Medicine

Dadaeva V.A.

National Medical Research Center for Therapy and Preventive Medicine

Lebedeva D.I.

Tyumen State Medical University

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
Russian University of Medicine

Received:

27.09.2024

Accepted:

25.10.2024

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