Polymorbidity (PM) is associated with increased hospitalization, disability, and mortality of patients, indicating the need to study PM in different populations.
OBJECTIVE
To study regional, gender, and age-specific PM features in residents of the Novosibirsk region (NR) and the Republic of Sakha (Yakutia).
MATERIAL AND METHODS
A retrospective single-center observational study of patients with medical conditions (a total of 26.671 subjects, including 10.495 males and 16.176 females) over the age of 18 years was conducted at the clinic of the Federal Research Centre for Fundamental and Translational Medicine (Novosibirsk) from 2003 to 2020. The study included 22.667 residents of the Novosibirsk region (NR) and 4.004 residents of the Republic of Sakha (Yakutia). The study used the archival method based on the data from medical records, considering all identified diagnoses in each patient as clinical entities and classes of the International Classification of Diseases of the 10th Revision (ICD-10). The PM was assessed by the number of ICD-10 classes in one patient. All patients were divided into subgroups depending on the region of residence, gender, and age.
RESULTS
It was found that the residents of Yakutia had a higher PM compared to the NR residents. This pattern was observed among males of adolescence and the second mature age periods and females of all ages, except for adolescence. The gender features of the PM were revealed, with higher rates of PM in the NR residents, young males, and females in the second mature and elderly age periods; in the residents of Yakutia females in all age periods, except for adolescence. Age-related PM features were revealed, with increased rates with increasing age.
CONCLUSION
Identified features of polymorbidity determine the need to consider the region of residence, gender, and age of patients to improve the prevention, diagnosis, and treatment system.