Despite the success in Russia in reducing the burden of non-communicable diseases, the level of morbidity and premature mortality as a result of these diseases remains quite high compared with developed countries. A comprehensive system of economic incentives for motivating citizens to lead a healthy lifestyle, developed with international, can contribute to reducing the burden. Objective — to develop general requirements for the design of an integrated system of economic mechanisms aimed at changing the behavior of people in relation to their health based on the synthesis of international experience. Material and methods. A systemic search for publications based on the developed protocol, a comprehensive analysis and systematization of the information received in certain areas of application of economic incentives aimed at changing the people’s behavior in regard to their health. Results. In international practice, a set of positive and negative incentives is used to change people’s behavior regarding their health. Governments play a leading role in developing economic incentives. The current international practice of applying economic mechanisms to influence people’s behavior is not straightforward. There are examples of the implementation of an unsuccessful, not thought-out fiscal strategy. The strategy for developing a healthy lifestyle, which is being developed in Russia, should to a greater extend apply a system of economic incentives implemented by various parties interested in improving the health status and targeting different population groups. The generalized international experience allows determining the principles, following which can contribute to the development of a better integrated strategy for the formation of health promotion. Conclusion. The practice of other countries demonstrates the need for an integrated approach to the formation of a holistic system of economic incentives. Such a system should take into account the interests of all actors, the leading role of the government in the development of financial schemes and mechanisms. The proposed system should take into account the possible positive and negative consequences of its introduction.