Objective — to develop a method for the integral estimation of the alcohol situation in the subjects of the Russian Federation on the basis of official statistics and to estimate regional differences in the level of alcohol wellbeing. Material and method. Seven indicators directly and indirectly characterizing the level of alcohol consumption were selected from the Uniform Interdepartmental Statistical Information System. Pearson’s correlation analysis was used to select indicators for forming the integral alcohol situation index (IASI) that was calculated on the basis of statistical data on death from acute alcohol intoxications or external causes, the difference between life expectancy (years) in women and men, the incidence of alcoholism and alcohol-related psychoses, and the per capita volume of retail vodka sales. The obtained values were linearly transformed in the range of 0 to 1 and conventionally divided into 4 categories of the alcohol situation: favorable, relatively favorable, relatively unfavorable, and unfavorable. Results. Analysis of the correlation between a change in different sale values of alcoholic drinks and in those characterizing the consequences of their consumption demonstrated that the retail sales of strong alcohol were more significant in characterizing its consumption than sales, calculated with reference to absolute alcohol. The favorable situation group included the regions of the North Caucasus Federal District and the majority of regions of the Southern Federal District (SFD). Most subjects with the relatively favorable situation formed part of the Central Federal District (CFD) (8 regions) and the Volga Federal District (VFD) (6 regions). The geography of regions with the relatively unfavorable situation was mainly represented by the subjects of the CFD (5 regions), the VFD (4 regions), and the North-Western Federal District (4 regions). The fourth group of regions with the lowest IASI was represented by those from different parts of the country. The most representative ones proved to be the Far Eastern Federal District (5 subjects), VFD (5), SFD (4), and CFD (3). Conclusion. The close statistical correlation between the values characterizing the consequences of alcohol consumption and the retail sales of strong alcoholic drinks allows their use for the integral estimation of the alcohol situation in the regions. The spatial distribution of the subjects of the Russian Federation in the level of alcohol ill-being is of complex nature that was determined by both national and socioeconomic factors.