The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Deryabina E.G.
Urals Scientific Research Institute for Maternal and Child Care
Ethinylestradiol and oral contraception: what we know after 60 years of use? (a review)
Journal: Russian Journal of Human Reproduction. 2024;30(4): 90‑100
Views: 495
Downloaded: 4
To cite this article:
Deryabina EG. Ethinylestradiol and oral contraception: what we know after 60 years of use? (a review). Russian Journal of Human Reproduction.
2024;30(4):90‑100. (In Russ.)
https://doi.org/10.17116/repro20243004190
More than 60 years have passed since the appearance of the first combined oral contraceptive (COC). Since then, the use of birth control pills has become widespread throughout the world, providing a simple, safe, effective and reversible regulation of fertility. Appearing in the composition of the first hormonal contraceptive pill as an accidental impurity in the form of its predecessor mestranol, ethinyl estradiol (EE) remained in the composition of COCs for 60 years. The first COCs contained higher concentrations of hormones than today and were associated with side effects. To reduce these effects, significant changes were made to the composition of COCs: the content of EE was reduced by 5 or more times, new highly selective progestogens and endogenous estrogens were developed. Today, COC preparations have become low-dose, safe and diverse, which allows you to choose the most suitable option for each individual woman. But most COCs still include EE as an estrogen component. This literature review 60 years of experience with EE in COCs and provides new data on the subject.
Authors:
Deryabina E.G.
Urals Scientific Research Institute for Maternal and Child Care
Received:
29.06.2023
Accepted:
05.09.2023
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.