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Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology

Tkachev N.A.

Semenov Institute of Chemical Physics Russian Academy of Sciences

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Vandysheva R.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Modelling and prevention of postoperative adhesions in gynaecological and pelvic surgery in experiment: morphological and ultrastructural features

Authors:

Adamyan L.V., Mikhaleva L.M., Tkachev N.A., Pivazyan L.G., Vandysheva R.A., Areshidze D.A., Mailova K.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(2): 42‑50

DOI: 10.17116/repro20243002142

Views: 496

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To cite this article:

Adamyan LV, Mikhaleva LM, Tkachev NA, Pivazyan LG, Vandysheva RA, Areshidze DA, Mailova KS. Modelling and prevention of postoperative adhesions in gynaecological and pelvic surgery in experiment: morphological and ultrastructural features. Russian Journal of Human Reproduction. 2024;30(2):42‑50. (In Russ.)
https://doi.org/10.17116/repro20243002142

Подписка 2025 (Russian Journal of Human Reproduction)
 
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Adhesions of the pelvic organs are one of the most important unsolved problems of operative gynaecology, the complications of which are tubal-peritoneal infertility, chronic pelvic pain, violation of the anatomo-topographical location of the pelvic organs with disturbance of their architectonics and functional activity. The aim of the present work was to study and evaluate the effectiveness of the application of antiadhesion gel «Antiadhesin» based on hyaluronic acid to prevent the formation of adhesions in the postoperative period in the experiment. 11 female Wistar rats (obtained from FMBA nursery «Stolbovaya») divided into 2 groups: control (n=5 rats) and experimental (n=6) were used for modelling of adhesions in the pelvis. The conducted experimental study shows the effectiveness of hyaluronic acid-based gel, which consists in the reduction of inflammatory process, enhancement of tissue regeneration in the area of injury without activation of proliferative processes that lead to the development of granulation tissue, increased participation of fibroblasts and formation of dense collagen adhesions.

Keywords:

adhesions
surgery
postoperative adhesions
laparoscopy
experiment

Authors:

Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology

Tkachev N.A.

Semenov Institute of Chemical Physics Russian Academy of Sciences

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Vandysheva R.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Received:

29.03.2024

Accepted:

12.04.2024

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