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Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology

Tkachev N.A.

Semenov Institute of Chemical Physics Russian Academy of Sciences

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Vandysheva R.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Modelling and prevention of postoperative adhesions in gynaecological and pelvic surgery in experiment: morphological and ultrastructural features

Authors:

Adamyan L.V., Mikhaleva L.M., Tkachev N.A., Pivazyan L.G., Vandysheva R.A., Areshidze D.A., Mailova K.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(2): 42‑50

DOI: 10.17116/repro20243002142

Read: 1360 times

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Table of contents

MODELLING AND PREVENTION OF POSTOPERATIVE ADHESIONS IN GYNAECOLOGICAL AND PELVIC SURGERY IN EXPERIMENT: MORPHOLOGICAL AND ULTRASTRUCTURAL FEATURES
MODELLING AND PREVENTION OF POSTOPERATIVE ADHESIONS IN GYNAECOLOGICAL AND PELVIC SURGERY IN EXPERIMENT: MORPHOLOGICAL AND ULTRASTRUCTURAL FEATURES

To cite this article:

Adamyan LV, Mikhaleva LM, Tkachev NA, Pivazyan LG, Vandysheva RA, Areshidze DA, Mailova KS. Modelling and prevention of postoperative adhesions in gynaecological and pelvic surgery in experiment: morphological and ultrastructural features. Russian Journal of Human Reproduction. 2024;30(2):42‑50. (In Russ.)
https://doi.org/10.17116/repro20243002142

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Adhesions of the pelvic organs are one of the most important unsolved problems of operative gynaecology, the complications of which are tubal-peritoneal infertility, chronic pelvic pain, violation of the anatomo-topographical location of the pelvic organs with disturbance of their architectonics and functional activity. The aim of the present work was to study and evaluate the effectiveness of the application of antiadhesion gel «Antiadhesin» based on hyaluronic acid to prevent the formation of adhesions in the postoperative period in the experiment. 11 female Wistar rats (obtained from FMBA nursery «Stolbovaya») divided into 2 groups: control (n=5 rats) and experimental (n=6) were used for modelling of adhesions in the pelvis. The conducted experimental study shows the effectiveness of hyaluronic acid-based gel, which consists in the reduction of inflammatory process, enhancement of tissue regeneration in the area of injury without activation of proliferative processes that lead to the development of granulation tissue, increased participation of fibroblasts and formation of dense collagen adhesions.

Keywords:

adhesions
surgery
postoperative adhesions
laparoscopy
experiment

Authors:

Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology

Tkachev N.A.

Semenov Institute of Chemical Physics Russian Academy of Sciences

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Vandysheva R.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Received:

29.03.2024

Accepted:

12.04.2024

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References:

  1. Kulakov VI, Adamian LV, Mynbaev OA. Posleoperatsionnye spaiki (etiologiia, patogenez i profilaktika). M.: Meditsina; 1998. (In Russ.).
  2. Mynbaev OA. Etiologiia, patogenez i printsipy profilaktiki posleoperatsionnykh spaek u ginekologicheskikh bol’nykh: Dis. ... d-ra med. nauk. M. 1997. (In Russ.).
  3. Adamyan LV, Kozachenko AV, Kondratovich LM. Peritoneal adhesions: the history of researh, classification and pathogenesis (a review). Problemy reprodukcii. 2013;(6):7-13. (In Russ.).
  4. Ahmad G, Thompson M, Kim K, Agarwal P, Mackie FL, Dias S, Metwally M, Watson A. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. The Cochrane Database of Systematic Reviews. 2020;7(7):CD001298. https://doi.org/10.1002/14651858
  5. Diamond MP. Surgical Aspects of Infertility. In: Sciarra J, ed. Gynecology and Obstetrics. Vol. 5. Philadelphia: Harper & Row; 1988;1-23. 
  6. Diamond MP, Daniell JF, Feste J, Surrey MW, McLaughlin DS, Friedman S, Vaughn WK, Martin DC. Adhesion reformation and de novo adhesion formation after reproductive pelvic surgery. Fertility and Sterility. 1987;47(5):864-866.  https://doi.org/10.1016/s0015-0282(16)59181-x
  7. Diamond MP. Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group. Fertility and Sterility. 1996;66(6):904-10. 
  8. Corona R, Verguts J, Schonman R, Binda MM, Mailova K, Koninckx PR. Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model. Fertility and Sterility. 2011;95(4):1224-1228. https://doi.org/10.1016/j.fertnstert.2011.01.004
  9. Koninckx PR, Gomel V, Ussia A, Adamyan L. Role of the peritoneal cavity in the prevention of postoperative adhesions, pain, and fatigue. Fertility and Sterility. 2016;106(5):998-1010. https://doi.org/10.1016/j.fertnstert.2016.08.012
  10. Chaichian S, Saadat Mostafavi SR, Mehdizadehkashi A, Najmi Z, Tahermanesh K, Ahmadi Pishkuhi M, Jesmi F, Moazzami B. Hyaluronic acid gel application versus ovarian suspension for prevention of ovarian adhesions during laparoscopic surgery on endometrioma: a double-blind randomized clinical trial. BMC Women’s Health. 2022;22(1):33.  https://doi.org/10.1186/s12905-022-01607-2
  11. Kulakov VI, Adamyan LV. Endoskopiya v ginekologii. M.: Medicina; 2000. (In Russ.).
  12. Mynbaev OA, Molinas CR, Adamyan LV, Vanacker B, Koninckx PR: Pathogenesis of CO(2) pneumoperitoneum-induced metabolic hypoxemia in a rabbit model. The Journal of the American Association of Gynecologic Laparoscopists. 2002;9(3):306-314.  https://doi.org/10.1016/s1074-3804(05)60409-4
  13. Mynbaev OA, Molinas CR, Adamyan LV, Vanacker B, Koninckx PR. Reduction of CO(2)-pneumoperitoneum-induced metabolic hypoxaemia by the addition of small amounts of O(2) to the CO(2) in a rabbit ventilated model. A preliminary study. Human Reproduction. 2002;17(6):1623-1629. https://doi.org/10.1093/humrep/17.6.1623
  14. Corona R, Mailova K, Binda MM, Verguts J, Koninckx PR: Addition of nitrous oxide to the carbon dioxide pneumoperitoneum strongly decreases adhesion formation and the dose dependent adhesiogenic effect of blood in a laparoscopic mouse model. Fertility and Sterility. 2013;100(6):83-1777. https://doi.org/10.1016/j.fertnstert.2013.08.049
  15. Mailova K, Osipova AA, Corona R, Binda MM, Koninckx PR, Adamian LV: Intraoperative bleeding: Adhesion formation and methods of their prevention in mice. Problemy reprodukcii. 2012;2:18-22. (In Russ.).
  16. Ghobrial S, Ott J, Parry JP. An Overview of Postoperative Intraabdominal Adhesions and Their Role on Female Infertility: A Narrative Review. Journal of Clinical Medicine. 2023;12(6):2263. https://doi.org/10.3390/jcm12062263
  17. Binda MM, Molinas CR, Hansen P, Koninckx PR. Effect of desiccation and temperature during laparoscopy on adhesion formation in mice. Fertility and Sterility. 2006;86(1):166-175.  https://doi.org/10.1016/j.fertnstert.2005.11.079
  18. Binda MM, Koninckx PR. Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioning. Human Reproduction. 2009;24: 1473-1479.
  19. Molinas CR, Mynbaev O, Pauwels A, Novak P, Koninckx PR. Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertility and Sterility. 2001;76:560-567. 
  20. Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. Journal of Ovarian Research. 2013;6(1):90.  https://doi.org/10.1186/1757-2215-6-90
  21. Liu C, Lu Q, Zhang Z, Xue M, Zhang Y, Zhang Y, Wang H, Li H, Zhou Y, Zhang Z, Li W; HyaRegen Adhesion Study Group. A Randomized Controlled Trial on the Efficacy and Safety of a New Crosslinked Hyaluronan Gel in Reducing Adhesions after Gynecologic Laparoscopic Surgeries. Journal of Minimally Invasive Gynecology. 2015;22(5):853-863.  https://doi.org/10.1016/j.jmig.2015.04.011
  22. Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, Yaşar L. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. Journal of Obstetrics and Gynaecology. 2021;41(2): 263-268.  https://doi.org/10.1080/01443615.2020.1755628
  23. Koninckx PR, Ussia A, Adamyan L. The role of the peritoneal cavity in adhesion formation. Fertility and Sterility. 2012;97(6):1297. https://doi.org/10.1016/j.fertnstert.2012.04.017
  24. Ahmad G, Kim K, Thompson M, Agarwal P, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. The Cochrane Database of Systematic Reviews. 2020; 3(3):CD000475. https://doi.org/10.1002/14651858.CD000475
  25. Mailova KS. Faktory riska i profilaktika spaechnogo processa pri laparoskopii v ginekologii: Dis. ... kand. med. nauk. M. 2012. (In Russ.).
  26. Fernandes IR, Russo FB, Pignatari GC, Evangelinellis MM, Tavolari S, Muotri AR, Beltrão-Braga PC. Cytotechnology. 2016; 68(2):223-228.  https://doi.org/10.1007/s10616-014-9771-7
  27. Xu X, Kong DS, Tian YP, Xie YL, Zhang JK, Huang XH. Autocross-linked hyaluronic acid gel and adipose-derived mesenchymal stem cell composites for the treatment intrauterine adhesions. Taiwan Journal of Obstetrics and Gynecology. 2021;60(6):1031-1037. https://doi.org/10.1016/j.tjog.2021.09.014
  28. van Steensel S, Liu H, Vercoulen TF, Hadfoune M, Breukink SO, Stassen LP, Lenaerts K, Bouvy ND. Prevention of intra-abdominal adhesions by a hyaluronic acid gel; an experimental study in rats. Journal of Biomaterials Applications. 2021;35(7):887-897.  https://doi.org/10.1177/0885328220954188
  29. Stratakis K, Arkoumanis T, Liakea A, Nikiteas N, Zargaran D, Zargaran A, Kontzoglou K, Kyriakopoulou P, Perrea D. Platelet-rich Plasma Gel versus Hyaluronic Acid on Prevention of Peritoneal Abdominal Adhesion Formation in Rats. Chirurgia. 2022;117(5): 585-593.  https://doi.org/10.21614/chirurgia.2737
  30. Guo J, Wei C, Wang X, Hou Y, Guo W. An in situ mechanical adjustable double crosslinking hyaluronic acid/poly-lysine hydrogel matrix: Fabrication, characterization and cell morphology. International Journal of Biological Macromolecules. 2021;180:234-241.  https://doi.org/10.1016/j.ijbiomac.2021.03.071
  31. Krielen P, Stommel MWJ, Pargmae P, Bouvy ND, Bakkum EA, Ellis H, Parker MC, Griffiths EA, van Goor H, Ten Broek RPG. Adhesion-related readmissions after open and laparoscopic surgery: a retrospective cohort study (SCAR update). Lancet. 2020;395(10217): 33-41.  https://doi.org/10.1016/S0140-6736(19)32636-4
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