The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Gabidullina R.I.

Kazan State Medical University

Galimyanova E.I.

Kazan State Medical University

Salakhova R.R.

City Clinical Hospital No. 7

Effects of combined oral contraceptives on female sexuality: continuing the conversation

Authors:

Gabidullina R.I., Galimyanova E.I., Salakhova R.R.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(5): 54‑61

Read: 10325 times


To cite this article:

Gabidullina RI, Galimyanova EI, Salakhova RR. Effects of combined oral contraceptives on female sexuality: continuing the conversation. Russian Journal of Human Reproduction. 2021;27(5):54‑61. (In Russ.)
https://doi.org/10.17116/repro20212705154

Recommended articles:
Hormonal contraception methods and multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):24-30

References:

  1. Nappi RE, Tiranini L. “50 Shades of sex” under hormonal contraception. Gynecological Endocrinology. 2020;36(9):753-754.  https://doi.org/10.1080/09513590.2020.1811847
  2. Both S, Lew-Starowicz M, Luria M, Sartorius G, Maseroli E, Tripodi F, Lowenstein L, Nappi RE, Corona G, Reisman Y, Vignozzi L. Hormonal contraception and female sexuality: position statements from the European Society of Sexual Medicine (ESSM). The Journal of Sexual Medicine. 2019;16(11):1681-1695. https://doi.org/10.1016/j.jsxm.2019.08.005
  3. United Nations, Department of Economic and Social Affairs, Population Division. Contraceptive Use by Method 2019: Data Booklet (ST/ESA/SER.A/435).
  4. Burrows LJ, Basha M, Goldstein AT. The Effects of Hormonal Contraceptives on Female Sexuality: A Review. The Journal of Sexual Medicine. 2012;9(9):2213-2223. https://doi.org/10.1111/j.1743-6109.2012.02848.x
  5. Black A, Guilbert E, Costescu D, Dunn S, Fisher W, Kives S, Mirosh M, Norman WV, Pymar H, Reid R, Roy G, Varto H, Waddington A, Wagner MS, Whelan AM. No. 329-Canadian Contraception Consensus Part 4 of 4 Chapter 9: Combined Hormonal Contraception. Journal of Obstetrics and Gynaecology Canada: JOGC. 2017; 39(4):229-268.e5.  https://doi.org/10.1016/j.jogc.2016.10.005
  6. Sanders SA, Graham CA, Bass JL, Bancroft J. A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception. 2001;64(1):51-58.  https://doi.org/10.1016/s0010-7824 (01) 00218-9
  7. Casado-Espada NM, de Alarcón R, de la Iglesia-Larrad JI, Bote-Bonaechea B, Montejo Á. Hormonal Contraceptives, Female Sexual Dysfunction, and Managing Strategies: A Review. Journal of Clinical Medicine. 2019;8(6):908.  https://doi.org/10.3390/jcm8060908
  8. De Castro Coelho F, Barros C. The Potential of Hormonal Contraception to Influence Female Sexuality. International Journal of Reproductive Medicine. 2019;2019:9701384. https://doi.org/10.1155/2019/9701384
  9. Huang M, Li G, Liu J, Li Y, Du P. Is there an association between contraception and sexual dysfunction in women? A systematic review and meta-analysis based on female sexual function index. The Journal of Sexual Medicine. 2020;17(10):1942-1955. https://doi.org/10.1016/j.jsxm.2020.06.008
  10. Pastor Z, Holla K, Chmel R. The influence of combined oral contraceptives on female sexual desire: a systematic review. The European Journal of Contraception and Reproductive Health Care. 2013; 18(1):27-43.  https://doi.org/10.3109/13625187.2012.728643
  11. Boozalis A, Tutlam NT, Chrisman Robbins C, Peipert JF. Sexual Desire and Hormonal Contraception. Obstetrics and Gynecology. 2016;127(3):563-572.  https://doi.org/10.1097/AOG.0000000000001286
  12. Casey PM, MacLaughlin KL, Faubion SS. Impact of Contraception on Female Sexual Function. Journal of Women’s Health. 2017; 26(3):207-213.  https://doi.org/10.1089/jwh.2015.5703
  13. Smith NK, Jozkowski KN, Sanders SA. Hormonal contraception and female pain, orgasm and sexual pleasure. The Journal of Sexual Medicine. 2014;11(2):462-470.  https://doi.org/10.1111/jsm.12409
  14. Raudrant D, Rabe T. Progestogens with antiandrogenic properties. Drugs. 2003;63(5):463-492.  https://doi.org/10.2165/00003495-200363050-00003
  15. Sitruk-Ware R. New progestagens for contraceptive use. Human Reproduction Update. 2006;12(2):169-178.  https://doi.org/10.1093/humupd/dmi046
  16. Graziottin A. The shorter, the better: A review of the evidence for a shorter contraceptive hormone-free interval. The European Journal of Contraception and Reproductive Health Care. 2016;21(2):93-105.  https://doi.org/10.3109/13625187.2015.1077380
  17. Thomas HN, Thurston RC. A biopsychosocial approach to women’s sexual function and dysfunction at midlife: A narrative review. Maturitas. 2016;87:49-60.  https://doi.org/10.1016/j.maturitas.2016.02.009
  18. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D’Agostino R Jr. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D’Agostino R Jr. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex and Marital Therapy. 2000;26(2):191-208.  https://doi.org/10.1080/009262300278597
  19. Lee Y, Lim MC, Joo J, Park K, Lee S, Seo S, Lee DO, Park SY. Development and validation of the Korean version of the Female Sexual Function Index-6 (FSFI-6K). Yonsei Medical Journal. 2014; 55(5):1442-1446. https://doi.org/10.3349/ymj.2014.55.5.1442
  20. Wallwiener CW, Wallwiener LM, Seeger H, Schönfisch B, Mueck AO, Bitzer J, Zipfel S, Brucker SY, Taran FA, Wallwiener M. Are hormonal components of oral contraceptives associated with impaired female sexual function? A questionnaire-based online survey of medical students in Germany, Austria, and Switzerland. Archives of Gynecology and Obstetrics. 2015;292(4):883-890.  https://doi.org/10.1007/s00404-015-3726-x
  21. Zethraeus N, Dreber A, Ranehill E, Blomberg L, Labrie F, von Schoultz B, Johannesson M, Hirschberg AL. Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial. The Journal of Clinical Endocrinology and Metabolism. 2016;101(11):4046-4053. https://doi.org/10.1210/jc.2016-2032
  22. Basson R. Women’s sexual dysfunction: revised and expanded definitions. CMAJ: Canadian Medical Association Journal. 2005; 172(10):1327-1333. https://doi.org/10.1503/cmaj.1020174
  23. Scheele D, Plota J, Stoffel-Wagner B, Maier W, Hurlemann R. Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face. Social Cognitive and Affective Neuroscience. 2016;11(5):767-774.  https://doi.org/10.1093/scan/nsv157
  24. Gabidullina RI, Galimyanova EI, Eremkina VI, Sharapova AM. Effect of combined oral contraceptive containing 17β-estradiol on female sexual function, depression and quality of life. Prakticheskaya meditsina. 2020;18(6):43-48. (In Russ.). https://doi.org/10.32000/2072-1757-2020-6-43-48
  25. Bjelica A, Kapamadzija A, Maticki-Sekulić M. Hormones and female sexuality. Medicinski Pregled. 2003;56(9-10):446-450.  https://doi.org/10.2298/MPNS0310446B
  26. Davison SL, Davis SR. Androgens in women. The Journal of Steroid Biochemistry and Molecular Biology. 2003;85(2-5):363-366.  https://doi.org/10.1016/s0960-0760(03)00204-8
  27. Stomati M, Genazzani AD, Petraglia F, Genazzani AR. Contraception as prevention and therapy: sex steroids and the brain. The European Journal of Contraception and Reproductive Health Care. 1998; 3(1):21-28.  https://doi.org/10.3109/13625189809167481
  28. Curtis KM, Jatlaoui TC, Tepper NK, Zapata LB, Horton LG, Jamieson DJ, Whiteman MK. U.S. selected practice recommendations for contraceptive use, 2016. MMWR. Recommendations and Reports. 2016;65(4):1-66.  https://doi.org/10.15585/mmwr.rr6504a1
  29. Nusbaum MR, Helton MR, Ray N. The changing nature of women’s sexual health concerns through the midlife years. Maturitas. 2004;49(4):283-291.  https://doi.org/10.1016/j.maturitas.2004.06.014
  30. Sobecki JN, Curlin FA, Rasinski KA, Lindau ST. What we don’t talk about when we don’t talk about sex: results of a national survey of U.S. obstetrician/gynecologists. The Journal of Sexual Medicine. 2012;9(5):1285-1294. https://doi.org/10.1111/j.1743-6109.2012.02702.x
  31. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed. Washington, DC, USA; 2013.
  32. ESHRE Capri Workshop Group. Female contraception over 40. Human Reproduction Update. 2009;15(6):599-612.  https://doi.org/10.1093/humupd/dmp020
  33. Fruzzetti F, Paoletti AM, Fidecicchi T, Posar G, Giannini R, Gambacciani M. Contraception with estradiol valerate and dienogest: adherence to the method. Open Access Journal of Contraception. 2019;10:1-6.  https://doi.org/10.2147/OAJC.S204655
  34. Yu Q, Huang Z, Ren M, Chang Q, Zhang Z, Parke S. Contraceptive efficacy and safety of estradiol valerate/dienogest in a healthy female population: a multicenter, open-label, uncontrolled Phase III study. International Journal of Women’s Health. 2018;10:257-266.  https://doi.org/10.2147/IJWH.S157056
  35. Nelson A, Parke S, Makalova D, Serrani M, Palacios S, Mellinger U. Efficacy and bleeding profile of a combined oral contraceptive containing oestradiol valerate/dienogest: a pooled analysis of three studies conducted in North America and Europe. The European Journal of Contraception and Reproductive Health Care. 2013;18(4): 264-273.  https://doi.org/10.3109/13625187.2013.780202
  36. Barnett C, Dinger J, Minh TD, Heinemann K. Unintended pregnancy rates differ according to combined oral contraceptive — results from the INAS-SCORE study. The European Journal of Contraception and Reproductive Health Care. 2019;24(4):247-250.  https://doi.org/10.1080/13625187.2019.1629412
  37. Jensen JT, Bitzer J, Nappi RE, Ahlers C, Bannemerschult R, Parke S. Pooled analysis of bleeding profile, efficacy and safety of oral oestradiol valerate/dienogest in women aged 25 and under. The European Journal of Contraception and Reproductive Health Care. 2020; 25(2):98-105.  https://doi.org/10.1080/13625187.2020.1731734
  38. Caruso S, Agnello C, Romano M, Cianci S, Lo Presti L, Malandrino C, Cianci A. Preliminary study on the effect of four-phasic estradiol valerate and dienogest (E2V/DNG) oral contraceptive on the quality of sexual life. The Journal of Sexual Medicine. 2011; 8(10):2841-2850. https://doi.org/10.1111/j.1743-6109.2011.02409.x
  39. Davis SR, Bitzer J, Giraldi A, Palacios S, Parke S, Serrani M, Mellinger U, Nappi RE. Change to either a nonandrogenic or androgenic progestin-containing oral contraceptive preparation is associated with improved sexual function in women with oral contraceptive-associated sexual dysfunction. The Journal of Sexual Medicine. 2013;10(12):3069-3079. https://doi.org/10.1111/jsm.12310
  40. Di Carlo C, Gargano V, De Rosa N, Tommaselli GA, Sparice S, Nappi C. Effects of estradiol valerate and dienogest on quality of life and sexual function according to age. Gynecological Endocrinology. 2014;30(12):925-928.  https://doi.org/10.3109/09513590.2014.975688
  41. Chen J, Ho SC. Contraceptive status and sexual function of climacteric Chinese women. Contraception. 1999;59(2):85-90.  https://doi.org/10.1016/s0010-7824 (99) 00005-0
  42. Briggs P, Serrani M, Vogtländer K, Parke S. Continuation rates, bleeding profile acceptability, and satisfaction of women using an oral contraceptive pill containing estradiol valerate and dienogest versus a progestogen-only pill after switching from an ethinylestradiol-containing pill in a real-life setting: results of the CONTENT study. International Journal of Women’s Health. 2016;8:477-487.  https://doi.org/10.2147/IJWH.S107586
  43. Ahrendt HJ, Makalová D, Parke S, Mellinger U, Mansour D. Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel. Contraception. 2009;80(5):436-444.  https://doi.org/10.1016/j.contraception.2009.03.018
  44. Grandi G, Napolitano A, Cagnacci A. Metabolic impact of combined hormonal contraceptives containing estradiol. Expert Opinion on Drug Metabolism and Toxicology. 2016;12(7):779-787.  https://doi.org/10.1080/17425255.2016.1190832
  45. Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Practice and Research. Clinical Endocrinology and Metabolism. 2013;27(1):13-24.  https://doi.org/10.1016/j.beem.2012.09.004
  46. Wiegratz I, Lee JH, Kutschera E, Winkler UH, Kuhl H. Effect of four oral contraceptives on hemostatic parameters. Contraception. 2004;70(2):97-106.  https://doi.org/10.1016/j.contraception
  47. Haverinen A, Kangasniemi M, Luiro K, Piltonen T, Heikinheimo O, Tapanainen JS. Ethinyl estradiol vs estradiol valerate in combined oral contraceptives — Effect on glucose tolerance: A randomized, controlled clinical trial. Contraception. 2021;103(1):53-59.  https://doi.org/10.1016/j.contraception.2020.10.014
  48. Kangasniemi MH, Haverinen A, Luiro K, Hiltunen JK, Komsi EK, Arffman RK, Heikinheimo O, Tapanainen JS, Piltonen TT. Estradiol Valerate in COC Has More Favorable Inflammatory Profile Than Synthetic Ethinyl Estradiol: A Randomized Trial. The Journal of Clinical Endocrinology and Metabolism. 2020;105(7):dgaa186. https://doi.org/10.1210/clinem/dgaa186
  49. Grøntvedt TV, Grebe NM, Kennair LEO, Gangestad SW. Estrogenic and progestogenic effects of hormonal contraceptives in relation to sexual behavior: insights into extended sexuality. Evolution and Human Behavior. 2017;38:283292. https://doi.org/10.1016/j.evolhumbehav.2016.10.006
  50. Harada T, Taniguchi F. Dienogest: a new therapeutic agent for the treatment of endometriosis. Womens Health. 2010;6(1):27-35.  https://doi.org/10.2217/WHE.09.72
  51. Espitia De La Hoz FJ. O-08 Alteration of the Sexual Response Cycle in Women Using Combined Oral Contraceptives. The Journal of Sexual Medicine. 2017;14:e374. https://doi.org/10.1016/j.jsxm.2017.10.017
  52. Dinger J, Do Minh T, Heinemann K. Impact of estrogen type on cardiovascular safety of combined oral contraceptives. Contraception. 2016;94(4):328-39.  https://doi.org/10.1016/j.contraception.2016.06.010
  53. Merki-Feld GS, Caetano C, Porz TC, Bitzer J. Are there unmet needs in contraceptive counselling and choice? Findings of the European TANCO Study. The European Journal of Contraception and Reproductive Health Care. 2018;23(3):183-193.  https://doi.org/10.1080/13625187.2018.1465546
  54. Macìas G, Merki-Feld GS, Parke S, Mellinger U, Serrani M. Effects of a combined oral contraceptive containing oestradiol valerate/dienogest on hormone withdrawal-associated symptoms: results from the multicentre, randomised, double-blind, active-controlled HARMONY II study. Journal of Obstetrics and Gynaecology. 2013; 33(6):591-596.  https://doi.org/10.3109/01443615.2013.800851

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.