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Voznesenskaia T.Iu.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Blashkiv T.V.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

The role of sirtuins in regulation of the ovarian function (a review)

Authors:

Voznesenskaia T.Iu., Blashkiv T.V.

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Journal: Russian Journal of Human Reproduction. 2018;24(1): 7‑12

DOI: 10.17116/repro20182417-12

Read: 2827 times

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THE ROLE OF SIRTUINS IN REGULATION OF THE OVARIAN FUNCTION (A REVIEW)
THE ROLE OF SIRTUINS IN REGULATION OF THE OVARIAN FUNCTION (A REVIEW)

To cite this article:

Voznesenskaia TIu, Blashkiv TV. The role of sirtuins in regulation of the ovarian function (a review). Russian Journal of Human Reproduction. 2018;24(1):7‑12. (In Russ.)
https://doi.org/10.17116/repro20182417-12

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
To the question of human oocy­tes dysmorphism and its influence on the para­meters of early embryogenesis. Russian Journal of Human Reproduction. 2025;(3):48-54
Abstract:

Sirtuins (Sirtuins, SIRTs — silent information regulators) remove acetyl groups from cellular proteins and such post-translational modification significantly affects the localization and function of proteins. To date, seven members of the Sirtuin family have been identified in mammals (SIRT1-7), and each has a specific intracellular localization, function, and substrate specificity. The presence of SIRT1 and SIRT2 in the nucleus and in the cytoplasm was established; SIRT3, SIRT4 and SIRT5 — exclusively in mitochondria, SIRT6 and SIRT7 — only in the nucleus. During the last 15 years, the action of sirtuins is associated with the cell aging. Interest in studying the role of sirtuins in reproductive physiology has been growing over the past few years. At present, studies of mammalian sirtuins focus mainly on SIRT1, which is perhaps the homologue to SIRT2 yeast. The study of the role of sirtuins SIRT1 and SIRT3 in the oocyte meiotic maturation is promising, and could contribute to positive results in IVF by improving the quality of oocytes and increasing the potential for the development of early embryos. The purpose of the work is the collection and analysis of literature data on the role of sirtuins in the regulation of ovarian function.

Keywords:

sirtuins
ovarian function
oocyte
embryo
sirtuins
ovarian function
oocyte
embryo

Authors:

Voznesenskaia T.Iu.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Blashkiv T.V.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

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