Objective. To study the molecular and genetic mechanisms of angiogenesis regulation, phenotypic features decidualized endometrium and trophoblast invasion in patients with non-developing pregnancy. Material and methods. The study involved 116 women with non-developing pregnancy in the first trimester and 116 women with physiological pregnancy in the first trimester, which has made artificial abortion. It was studied polymorphisms of genes VEGF-A 936C>T, VEGF-A 634G>C by PCR in real-time mothers and their embryonic tissues. Histological examination of chorionic villi, tissue endometrial cells membranes resulting vacuum aspiration of the ovum from the uterus was performed according to standard procedures and stained with hematoxylin-eosin on microscope CarlZeissPrimoStar. Results. Women with non-developing pregnancy with reduced vascularity of chorionic villi, significantly more often determined by the genotype containing the polymorphic allele 634S gene VEGF-A 634G>C (OR=1.7; CI 95% 0.93-3.11; p=0.04). When combined allelic genotyping system of mother-fetus in women with non-developing pregnancy significantly more often determined by the genotype of a polymorphic allele 936T gene VEGF-A 936C>T (OR=1.61; CI 95% 1.04-2.48; p=0.03). According to morphometry in 79% of patients with non-developing pregnancy with carrier identified polymorphisms, had an abnormal morphological features of the system of blood supply uteroplacental endometrial area. Conclusion. Genetically deterministic underdevelopment of the system of blood supply uteroplacental endometrial areas can play a key role in the violation of the first wave of trophoblast invasion processes when developing pregnancy.