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Bobkova M.V.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» (dir. — Acad. RAN G.T. Sukhikh) Moscow, Russia, 117997

Baranova E.E.

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Genetic aspects of vagina and the uterus aplasia: the history

Authors:

Bobkova M.V., Baranova E.E., Adamyan L.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2015;21(3): 10‑15

DOI: 10.17116/repro201521310-15

Views: 1890

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GENETIC ASPECTS OF VAGINA AND THE UTERUS APLASIA: THE HISTORY
GENETIC ASPECTS OF VAGINA AND THE UTERUS APLASIA: THE HISTORY

To cite this article:

Bobkova MV, Baranova EE, Adamyan LV. Genetic aspects of vagina and the uterus aplasia: the history. Russian Journal of Human Reproduction. 2015;21(3):10‑15. (In Russ.)
https://doi.org/10.17116/repro201521310-15

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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The article presents the basic hypothesis of Meyer—Rokitansky—Kustner—Hauser syndrome (uterus and vagina aplasia) development and the modern criteria of this syndrome. The potential role of teratogens, genes mutations or deletions and epigenetic gene regulation disorders are discussed. The management of patients with uterus and the vagina aplasia should be based on an integrated approach combining with a complete medical and family history, physical and laboratory examinations, as well as, genetic testing.

Keywords:

vagina and the uterus aplasia
the Mayer—Rokitansky—Küstner—Hauser syndrome
teratogens
knockout mice
candidate genes
epigenetics

Authors:

Bobkova M.V.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» (dir. — Acad. RAN G.T. Sukhikh) Moscow, Russia, 117997

Baranova E.E.

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

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