Objective. To compare three protocols of controlled ovarian stimulation used in oocyte donors. Material and Methods. 270 protocols of controlled ovarian stimulation in 121 oocyte donor were analyzed: group 1 — long protocol with aGnRH (n=70), group 2 — protocols with antGnRH (n=151), and group 3 — modified protocol with CC and rFSH (n=49). Results. The results of this study showed that the most efficient protocol in oocyte donation cycles is a modified protocol. Conclusions. The protocol selection in ART programs should be made according to the  ovarian reserve. The use of  modified protocol in oocyte donation cycles resulted in receiving of the highest number of mature ooctes. The use of aGnRH as a trigger provided good number of mature oocytes. Vitrification is an important part of modern oocyte donation program that provides high survival rate of oocytes.