Background. The results of inpatient treatment withcombined therapy for the first trimester retrochorial hematoma in patients with pregnancy loss is not well studied. Objectives. To evaluate the effect of combination therapy in conjunction with inpatient treatment for the first trimester retrochorial hematoma for patients with recurrent pregnancy loss and to study pro-inflammatory serum cytokines activity compare to controls. Method. Intervention group consisted of 100 pregnant women with retrochorial hematoma and control group of 60 women with normal pregnancy at the same gestational age. Gestational age ranged from 4 to 13th week of pregnancy. Combined therapy included the use of Valeriana extract or motherwort, magnesium sulfate, Drotaverine or papaverine, dydrogesterone or micronized progesterone for 4 weeks. Results. The combined inpatient therapy was associated with 7% spontaneous miscarriage rate, 11% moderate abdominal pain, 2% genital bleeding, 4% combination of two symptoms, 14% - hematoma with symptoms of regression, 5% - persistent hematoma. Comparative analysis showed that persistent hematoma was more common in patients with its initially large diameter. Before treatment the levels of IFN-, IFN-, IL-2 were increased in patients with retrochorial hematoma compare to controls (p<0.001) and the levels of IL-4 and IL-10 were decreased to 2.5 and 2.7 times respectively (p<0.001 for both). After the treatment levels of Il-2 and IFN-, IFN- were significantly reduced (p<0,001) compare to before treatment levels, and levels of IL-4 IL-10, increased to 2.6 and 2.8 times respectively (p<0.001). Conclusion. The combined inpatient therapy for the first trimester retrochorial hematoma in patients with pregnancy loss is associated with an improvement in clinical symptoms and pro-inflammatory activity in most of patients.