The role of vulvovaginal opportunistic infections and inborn immunity in pregnants with realization of fetal infection

Tiutiunnik V.L.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Kan N.E.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» Ministry of Healthcare of the Russian Federation, Moscow, Russia

Karapetian T.É.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Lomova N.A.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdrava Rossii, Moskva

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

The role of vulvovaginal opportunistic infections and inborn immunity in pregnants with realization of fetal infection

Authors:

Tiutiunnik V.L., Kan N.E., Karapetian T.É., Lomova N.A., Kogan E.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2013;(4): 95‑98

Downloaded: 1

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Tiutiunnik VL, Kan NE, Karapetian TÉ, Lomova NA, Kogan EA. The role of vulvovaginal opportunistic infections and inborn immunity in pregnants with realization of fetal infection. Russian Journal of Human Reproduction. 2013;(4):95‑98. (In Russ.)

Close metadata

Recommended articles:

Dynamics of expression of NOD-like receptors of periodontal tissue cells in patients with aggressive periodontitis. Stomatology. 2024;(6-2):10-14

The role of opportunistic vulvovaginal infections in pregnant women in the implementation of congenital infection in their newborns by measuring the intensity of color receptors for IL-6 and TLR2 in the tissue of the placenta was studied in two groups: with and without vulvovaginal opportunistic infections. Immunohistochemical investigation of two markers in 100 placentas was performed. The morphological and immunnogistochemical study of placentas showed the activation receptors for IL-6 as a largest response to infection. The level of NF-kB is increased in patients with bacterial vaginosis and combination of bacterial vaginosis and aerobic vaginitis. IL-6 receptor is increased in cyto- and syncytiotrophoblast in the group patients with aerobic vaginitis. Significant increase in NF-kB in vascular endothelium and macrophages in patients with a combination of bacterial vaginosis and aerobic vaginitis indicates the usefulness of this marker for determining the presence of inflammation in this group of patients.

Keywords:

innate immunity

opportunistic vulvovaginal infections

TSRs

IL receptor

Authors:

Tiutiunnik V.L.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Kan N.E.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» Ministry of Healthcare of the Russian Federation, Moscow, Russia

Karapetian T.É.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Lomova N.A.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdrava Rossii, Moskva

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

List of references:

Brotman R.M. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest 2011; 1: 121: 12: 4610-4617.
Ilkit M., Guzel A.B. The epidemiology, pathogenesis, and diagnosis of vulvovaginal candidosis: a mycological perspective. Crit Rev Microbiol 2011; 37: 3: 250-261.
Strizhakov A.N., Baev O.R., Budanov P.V. Sistema obsledovaniya i lecheniya beremennykh s narusheniyami mikrotsenoza rodovykh putei infektsiyami, peredavaemymi polovym putem, i voskhodyashchim infitsirovaniem ploda. Akush i gin 2003; 1: 47-52.
Kira E.F. Bakterial'nyi vaginoz. SPb: Neva-Lyuks 2001.
Gasieva M.A. Effektivnost' kombinirovannoi terapii bakterial'nykh vaginozov u beremennykh v profilaktike poslerodovykh infektsionnykh zabolevanii: Avtoref. dis. ... kand. med. nauk. Rostov-na-Donu 2009.
Audisio T., Penacino M., Cannistraci R., Bertolotto P. Detection of bacterial vaginosis, Trichomonas vaginalis infection, and vaginal Candida infection: a comparative study of methods of extracting exudates, with and without a speculum, during pregnancy. J Low Genit Tract Dis 2005; 9: 4: 213-215.
Lamont R.F., Taylor-Robinson D. The role of bacterial vaginosis, aerobic vaginitis, abnormal vaginal flora and the risk of preterm birth. BJOG 2010; 117: 1: 119-120.
Alvarez J.R., Williams S.F., Ganesh V.L., Apuzzij J.J. Duration of antimicrobial prophylaxis for group B streptococcus in patients with preterm premature rupture of membranes who are not in labor. Am J Obstet Gynecol 2007; 197: 4: 390. e 1-4.
Al-Sweih N., Hammoud M., Al-Shimmiri M. et al. Serotype distribution and mother-to-baby transmission rate of Streptococcus agalactiae among expectant mothers in Kuwait. Arch Gynecol Obstet 2005; 272: 2: 131-135.
Price D., Shaw E., Howard M. et al. Self-sampling for group B streptococcus in women 35 to 37 weeks pregnant is accurate and acceptable: a randomized cross-over triial. J Obstet Gynaecol Can 2006; 28: 12: 1083-1088.
Pereira L., Culhane J., McCollum K. et al. Variation in microbiologic profiles among pregnant women with bacterial vaginosis. Am J Obstet Gynecol 2005; 193: 3: 746-751.
Reagan P.B., Salsberry P.J. Race and ethnic differences in determinants of preterm birth in the USA:broadening the social context. Soc Sci Med 2005; 60: 10: 2217-2228.
Pettker C.M., Buhimschi I.A., Magloire L.K. et al. Value of Placental Microbial Evaluation in Diagnosing Intraamniotic Infection. Obstet Gynecol 2007; 109: 739-749.
Sukhikh G.T., Van'ko L.V. Immunologiya beremennosti. M: RAMN 2003.

Close metadata