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Fes'kov A.M.

Tsentr reproduktsii cheloveka "Klinika professora Fes'kova A.M.", Khar'kov

Fes'kova I.A.

Tsentr reproduktsii cheloveka "Klinika professora A.M. Fes'kova", Khar'kov

Zhilkova E.S.

Tsentr reproduktsii cheloveka "Klinika professora Fes'kova A.M.", Khar'kov

Egun'kova E.V.

Tsentr reproduktsii cheloveka "Klinika professora A.M. Fes'kova", Khar'kov

Allelic polymorphisms in folic exchanges genes in men with low reproductive function

Authors:

Fes'kov A.M., Fes'kova I.A., Zhilkova E.S., Egun'kova E.V.

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Journal: Russian Journal of Human Reproduction. 2013;(1): 70‑72

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To cite this article:

Fes'kov AM, Fes'kova IA, Zhilkova ES, Egun'kova EV. Allelic polymorphisms in folic exchanges genes in men with low reproductive function. Russian Journal of Human Reproduction. 2013;(1):70‑72. (In Russ.)

 
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The association between the meiosis failure during spermatogenesis and the presence of polymorphisms for MTHFR genes (C677T, A1298C), MTRR (A66G) in men with low reproductive function was examined. The correlation between the genetic failures on folic exchange process and the high content of aneuploid spermatozoa was found out (р <0,05).

Keywords:

real-time PCR
genes MTHFR and MTRR
aneuploidies
FISH

Authors:

Fes'kov A.M.

Tsentr reproduktsii cheloveka "Klinika professora Fes'kova A.M.", Khar'kov

Fes'kova I.A.

Tsentr reproduktsii cheloveka "Klinika professora A.M. Fes'kova", Khar'kov

Zhilkova E.S.

Tsentr reproduktsii cheloveka "Klinika professora Fes'kova A.M.", Khar'kov

Egun'kova E.V.

Tsentr reproduktsii cheloveka "Klinika professora A.M. Fes'kova", Khar'kov

List of references:

  1. Ekstrakorporal'noe oplodotvorenie i ego novye napravleniya v lechenii zhenskogo i muzhskogo besplodiya (teoreticheskie i prakticheskie podkhody): Rukovodstvo dlya vrachei. Pod red. V.I. Kulakova, B.V. Leonova. 2-e izd., dop. M: MIA 2004; 782.
  2. Daval J.L., Gue´ant J.L., Thierry Forges, Monnier-Barbarino P., Alberto J.M., Gue´ant-Rodriguez R.M. Impact of folate and homocysteine metabolism on human reproductive health. Human Reprod 2007; 13: 3: 225-238.
  3. Kelton Tremellen. Oxidative stress and male infertility - a clinical perspective. Human Reprod 2008; 14: 3: 243-258.
  4. Pierce K.E., Rice J.E., Aquiles Sanchez J., Wangh L.J. Detection of cystic fibrosis alleles from single cell using molecular beacons and a novel method of asymmetric real-time PCR. Mol Human Reprod 2003; 9: 12: 815-820.
  5. Matiezel I., Verheyen G., Van Assche E. et al. FISH analysis of chromosomes X, Y and 18 abnormalities in testicular sperm from azoospermic patients. Human Reprod 2002; 17: 9: 2249-2257.
  6. Sarah E.D., Sean P.F., Colin D.M. Detection of chromosomes and estimation of aneuploidy in human spermatozoa using in-situ hybridization. Mol Human Reprod 1997; 3: 7: 585-598.
  7. Glants S. Mediko-biologicheskaya statistika. M: Praktika 1999; 460.

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