The development of early mouse embryos in vitro in presence of dokosahexaenoyldopamine

Sakharova N.Iu.

FGBU "Institut teoreticheskoĭ i éksperimental'noĭ biofiziki" RAN, Pushchino

Markova L.N.

FGBU "Institut biologii razvitiia" RAN, Moskva

Smirnov A.A.

City Clinical Hospital Sixty-One, Moscow Healthcare Department, Moscow, Russia

Vikhliantseva E.F.

FGBU "Institut teoreticheskoĭ i éksperimental'noĭ biofiziki" RAN, Pushchino

Fialkovskaia L.A.

FGBU "Institut biofiziki kletki" RAN, Pushchino

Gretskaia N.M.

FGBU "Institut bioorganicheskoĭ khimii im. akademikov M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

Bezuglov V.V.

FGBU "Institut bioorganicheskoĭ khimii im. akademikov M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

The development of early mouse embryos in vitro in presence of dokosahexaenoyldopamine

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Sakharova N.Iu., Markova L.N., Smirnov A.A., Vikhliantseva E.F., Fialkovskaia L.A., Gretskaia N.M., Bezuglov V.V.

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Journal: Russian Journal of Human Reproduction. 2012;(3): 53‑59

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Sakharova NIu, Markova LN, Smirnov AA, Vikhliantseva EF, Fialkovskaia LA, Gretskaia NM, Bezuglov VV. The development of early mouse embryos in vitro in presence of dokosahexaenoyldopamine. Russian Journal of Human Reproduction. 2012;(3):53‑59. (In Russ.)

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We have studied the effect of dopamine conjugate with dokosahexaenoic acid (DHA-DA) on in vitro development of 2-, 4-, 8-cell mouse embryos. It was shown that DHA-DA did not stop the cleavage of 2-cell embryos but altered their compactizatiowhich started at the stage of 8 blastomeres. DHA-DA did not influence on the development of embryos till the stage of multicellular morula. The 8-cell embryos in the presence of DHA-DA developed a multicellular morulae but formed the abnormal blastocysts. DHA-DA provoked the significant anomalies in the structure of embryos. The opportunity of dopamine participation in connection with docosahexaenoic acid as a negative regulator of early embryo development is discussed.

Keywords:

mouse embryos

dopamine

dokosahexaenoic aci

Authors:

Sakharova N.Iu.

FGBU "Institut teoreticheskoĭ i éksperimental'noĭ biofiziki" RAN, Pushchino

Markova L.N.

FGBU "Institut biologii razvitiia" RAN, Moskva

Smirnov A.A.

City Clinical Hospital Sixty-One, Moscow Healthcare Department, Moscow, Russia

Vikhliantseva E.F.

FGBU "Institut teoreticheskoĭ i éksperimental'noĭ biofiziki" RAN, Pushchino

Fialkovskaia L.A.

FGBU "Institut biofiziki kletki" RAN, Pushchino

Gretskaia N.M.

FGBU "Institut bioorganicheskoĭ khimii im. akademikov M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

Bezuglov V.V.

FGBU "Institut bioorganicheskoĭ khimii im. akademikov M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

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