Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy

N.E. Manturova

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

F.N. Mistakopulo

Frau Clinic LLC

A.D. Zikiryakhodzhaev

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

ORCID: 0000-0001-7141-2502

S.M. Portnoy

Frau Clinic LLC

V.A. Sobolevskiy

Blokhin National Cancer Research Center

O.V. Krokhina

Blokhin National Cancer Research Center

A.S. Sukhotko

Moscow State University of Food Production

Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy

Authors:

N.E. Manturova, F.N. Mistakopulo, A.D. Zikiryakhodzhaev, S.M. Portnoy, V.A. Sobolevskiy, O.V. Krokhina, A.S. Sukhotko

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2020;(4): 5‑10

DOI: 10.17116/plast.hirurgia20200415

Downloaded: 233

To cite this article:

Manturova NE, Mistakopulo FN, Zikiryakhodzhaev AD, Portnoy SM, Sobolevskiy VA, Krokhina OV, Sukhotko AS. Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy. Plastic Surgery and Aesthetic Medicine. 2020;(4):5‑10. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia20200415

Доказательная гастроэнтерология: pro et contra

Актуальные вопросы педиатрической практики

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OBJECTIVE

To improve the quality of life in patients with BRCA1, BRCA2 gene mutations after simultaneous reconstructions during preventive mastectomy.

MATERIAL AND METHODS

The study included 78 patients with BRCA1, BRCA2 gene mutations. Breast cancer surgery and simultaneous preventive contralateral mastectomy were performed in 76 cases, bilateral preventive mastectomy — in 2 carriers of BRCA1 gene. Patients were divided into 2 groups depending on breast reconstruction method. In the 1^st group (n=36), radical subcutaneous/skin-sparing mastectomy was followed by simultaneous autologous flap reconstruction. In the 2^nd group (n=42), similar intervention was accompanied by simultaneous reconstruction with a silicone endoprosthesis (mesh implant/or acellular dermal matrix). All patients received combined/complex treatment depending on the stage of disease. Statistica v. 7 complex statistical package included multidimensional statistics and multivariate analysis. Quality of life was assessed using the BREAST-Q questionnaire.

RESULTS

We observed worse quality of life in the 1^st group compared to the 2^nd group according to all BREAST-Q items (p<0.05). Two patients who underwent bilateral preventive mastectomy were diagnosed with cr in situ in one of the mammary glands. None of the patients experienced progression of disease with local relapse and distant metastasis.

CONCLUSION

There was no cancer in the reconstructed breast, i.e. an efficacy of preventive surgery is 100%. Moreover, simultaneous reconstruction significantly improves the quality of life in these patients.

Keywords:

genetically associated breast cancer

BRCA1 and BRCA2 gene mutations

surgical prevention of breast cancer

Authors:

N.E. Manturova

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

F.N. Mistakopulo

Frau Clinic LLC

A.D. Zikiryakhodzhaev

ORCID: 0000-0001-7141-2502

S.M. Portnoy

Frau Clinic LLC

V.A. Sobolevskiy

Blokhin National Cancer Research Center

O.V. Krokhina

Blokhin National Cancer Research Center

A.S. Sukhotko

Moscow State University of Food Production

Received:

05.06.2020

Accepted:

30.07.2020

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