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Ma Ts.

Sechenov First Moscow State Medical University (Sechenov University)

Berikkhanov Z.G.

Sechenov First Moscow State Medical University

Timashev P.S.

Sechenov First Moscow State Medical University (Sechenov University)

Khristidis Ya.I.

Sechenov First Moscow State Medical University (Sechenov University)

Ivanova M.Yu.

Sechenov First Moscow State Medical University (Sechenov University)

Ershov B.P.

Sechenov First Moscow State Medical University (Sechenov University)

Liu Ts.

Sechenov First Moscow State Medical University (Sechenov University)

Tarabrin E.A.

Sechenov First Moscow State Medical University

A comparative study to evaluate the efficacy of sealants alone and in combination with collagen sheet in a pig isolated lung air leak model

Authors:

Ma Ts., Berikkhanov Z.G., Timashev P.S., Khristidis Ya.I., Ivanova M.Yu., Ershov B.P., Liu Ts., Tarabrin E.A.

More about the authors

Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(3): 23‑28

DOI: 10.17116/operhirurg2025903123

Read: 226 times

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Table of contents

A COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF SEALANTS ALONE AND IN COMBINATION WITH COLLAGEN SHEET IN A PIG ISOLATED LUNG AIR LEAK MODEL
A COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF SEALANTS ALONE AND IN COMBINATION WITH COLLAGEN SHEET IN A PIG ISOLATED LUNG AIR LEAK MODEL

To cite this article:

Ma Ts, Berikkhanov ZG, Timashev PS, et al. . A comparative study to evaluate the efficacy of sealants alone and in combination with collagen sheet in a pig isolated lung air leak model. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(3):23‑28. (In Russ.)
https://doi.org/10.17116/operhirurg2025903123

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

OBJECTIVE

This study aimed to evaluate the efficacy of three sealants (acrylate latex, fibrin-thrombin complex and cyanoacrylate derivative) alone or combined with collagen patches in sealing pulmonary air leaks using an ex vivo porcine lung model.

MATERIAL AND METHODS

Fresh porcine lungs (n=18) were standardized, and penetrating defects (2×2 cm) were created to simulate clinical air leakage. Lungs were connected to a mechanical ventilation system (PEEP=5 cm H2O, I:E=1:2). Samples were randomized into six groups (n=3/group) to test sealants alone or combined with 3×3 cm collagen patches. Air leakage frequency, patch stability, and maximum tolerated pressure were assessed by incrementally increasing ventilation pressures (20—50 cm H2O).

RESULTS

The cyanoacrylate glue + collagen patch group demonstrated 100% sealing integrity at the maximum ventilator pressure (50 cm H2O) without interface delamination, significantly outperforming other groups. In contrast, fibrin-thrombin glue + patch and latex glue + patch groups exhibited air leakage and patch detachment at 40 cm H2O and 25 cm H2O, respectively.

CONCLUSION

This ex vivo model effectively screened material combinations. Cyanoacrylate glue combined with collagen patches exhibited superior high-pressure sealing performance in the ex vivo setting. However, long-term efficacy and biocompatibility require further study.

Keywords:

ex vivo porcine lung model
pulmonary air leakage
sealants
collagen patches

Authors:

Ma Ts.

Sechenov First Moscow State Medical University (Sechenov University)

Berikkhanov Z.G.

Sechenov First Moscow State Medical University

Timashev P.S.

Sechenov First Moscow State Medical University (Sechenov University)

Khristidis Ya.I.

Sechenov First Moscow State Medical University (Sechenov University)

Ivanova M.Yu.

Sechenov First Moscow State Medical University (Sechenov University)

Ershov B.P.

Sechenov First Moscow State Medical University (Sechenov University)

Liu Ts.

Sechenov First Moscow State Medical University (Sechenov University)

Tarabrin E.A.

Sechenov First Moscow State Medical University

Received:

18.04.2025

Accepted:

23.05.2025

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References:

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