Study of wound healing effect of silver and cerium nanoparticles in treatment of uncomplicated skin wounds in an experiment

Zinchenko IA, Struts IS, Mirontsev AV, et al. . Study of wound healing effect of silver and cerium nanoparticles in treatment of uncomplicated skin wounds in an experiment. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;8(4):18‑24. (In Russ.)
https://doi.org/10.17116/operhirurg2024804118

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

Evaluation of the effectiveness of wound healing of uncomplicated flat wounds against the background of topical application of cerium and silver nanoparticles in a spray in an experiment on laboratory rats.

MATERIAL AND METHODS

The experimental study was performed on 40 Wistar rats, which were modeled with a layered skin wound with an area of 225 mm². The animals were randomly divided into 4 groups. The spray with the studied nanoparticles and the comparison drug dexpanthenol were applied to the wound once for 7 days. On days 3, 7, 14, 21, the wound area was measured to determine the rate of wound healing. The animals were withdrawn from the experiment on days 7, 14, 21 and 30 under general anesthesia, followed by wound tissue sampling for morphological examination. On day 30, the cosmetic effect of the postoperative scar was assessed using the SCAR scale.

RESULTS

Topical application of a spray containing silver (NS) and cerium (NC) nanoparticles reduces the time of complete healing of skin defects by 8±0.5 days (p<0.05), accelerates the wound healing process compared to the control group. On the 7^th day, the average wound healing rate was: in group K — 20.5±2.5 mm²/day; in group S — 29.3±1.8 mm²/day; in group C — 30.2±1.8 mm²/day; in group D — 21.3±9.8 mm²/day (p<0.05). The use of NS and NC improves the cosmetic characteristics of the scar, assessed on the SCAR scale: in group K — 5 points, in group S — 1 point, in group C — 1 point, in group D — 2 points.

CONCLUSION

The study demonstrated the effectiveness of NS and NC in the treatment of uncomplicated skin wounds, characterized by accelerated wound healing, antimicrobial and anti-inflammatory effects, formation of a scar with a smaller surface area and a more favorable cosmetic effect.

Keywords:

wound

scar

silver nanoparticles

cerium nanoparticles

Authors:

Zinchenko I.A.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0009-0007-6499-5659

Struts I.S.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0009-0001-9443-1244

Mirontsev A.V.

Sechenov First Moscow State Medical University (Sechenov University);
National Research Nuclear University

ORCID: 0000-0003-1783-694X

Klimentov S.M.

National Research Nuclear University

ORCID: 0000-0002-3632-4096

Dydykin S.S.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-1273-0356

Sorokvasha I.N.

National Research Nuclear University

ORCID: 0000-0002-8314-6616

Romanov M.D.

Ogarev State University

ORCID: 0000-0002-9646-4007

Eldyreva M.V.

Ulyanov State University

ORCID: 0000-0003-2076-9477

Blinova E.V.

Sechenov First Moscow State Medical University (Sechenov University);
National Research Nuclear University

ORCID: 0000-0003-0050-0251

Timoshkin S.P.

National Research Nuclear University

ORCID: 0000-0001-5518-6859

Received:

14.09.2024

Accepted:

03.10.2024

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