The paper describes two clinical cases of giant inguinoscrotal and postoperative ventral hernias and the results of their surgical treatment at Clinical Hospital Eighty-Five, Federal Biomedical Agency of Russia. Herniotomy was the first stage performed in a patient with left inguinoscrotal hernia. The size of the hernial sac was 40×30 cm. It was found to contain as high as 1 liter of transparent serous fluid. The hernial sac contained the contents of the small bowel with the mesentery almost all the way, the transverse colon with the greater omentum, and a part of the descending colon. The greater omentum, the left spermatic cord, and the left testicle were resected. Posterior inguinal canal wall plasty was carried out using Liechtenstein’s method. A parietene polypropylene mesh implant 20×20 cm was used as allomaterial. Due to trophic changes and skin infiltration in the left half, the scrotum was resected, followed by plasty. No postoperative complications were recorded. The surgical wound healed by primary intention. The patient was discharged from hospital in satisfactory condition at 10 days after surgery. The second clinical case is associated with surgical treatment for giant (W4) postoperative ventral hernia according to the Chevrel and Rath classification in a patient after previous laparotomy. Anterior abdominal wall plasty was made by mesh sublay placement beneath the musculus rectus abdominis. A Parietex, ProGrip Laparosopic (PPL) mesh produced by Covidien was applied. To prevent compartment syndrome, the anterior wall of the vagina musculi recti abdominis was postoperatively sutured using the autodermal graft pretreated by Yanov’s method. No postoperative complications were observed. The length of hospital stay after surgery was 12 days. No recurrences were seen in the early observation periods. Therefore, the correct choice of management and surgical tactics for patients with giant hernias, which combines an adequate preoperative diagnosis, preparation, and correction of comorbidity with the efficiency of allohernioplasty, naturally yields not only a positive treatment result, but also restores the patient’s quality of life.