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Baksiyan G.A.

Burnasyan Federal Medical Biophysical Center

Zavialov A.A.

Burnasyan Federal Medical Biophysical Center

Voskanyan S.E.

Burnasyan Federal Medical Biophysical Center

Lishuk S.V.

Burnasyan Federal Medical Biophysical Center

STAS — the fourth mechanism of invasion of malignant lung tumors. Impact on treatment outcomes

Authors:

Baksiyan G.A., Zavialov A.A., Voskanyan S.E., Lishuk S.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(3): 94‑99

DOI: 10.17116/onkolog20251403194

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Table of contents

STAS — THE FOURTH MECHANISM OF INVASION OF MALIGNANT LUNG TUMORS. IMPACT ON TREATMENT OUTCOMES
STAS — THE FOURTH MECHANISM OF INVASION OF MALIGNANT LUNG TUMORS. IMPACT ON TREATMENT OUTCOMES

To cite this article:

Baksiyan GA, Zavialov AA, Voskanyan SE, Lishuk SV. STAS — the fourth mechanism of invasion of malignant lung tumors. Impact on treatment outcomes. P.A. Herzen Journal of Oncology. 2025;14(3):94‑99. (In Russ.)
https://doi.org/10.17116/onkolog20251403194

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

In the world literature, there has been increased interest in the little-studied mechanism of invasion of malignant lung tumors, officially recognized by the WHO only in 2015. This route of invasion was called STAS (spread through air spaces). It has now been proven that STAS significantly worsens the course of malignant lung tumors and correlates with the rate of local relapses after surgical treatment, especially when performing sublobar resections. This article covers the current state of the problem associated with relapses after surgical treatment of malignant (primary and secondary) lung tumors caused by the presence of the STAS invasion component in tumors. The study of the STAS phenomenon will complement the complex picture of carcinogenesis in lung tissue and will allow a more conscious approach to the issue of surgical treatment of malignant lung pathology, including in the sublobar variant.

Keywords:

spread through air spaces
STAS

Authors:

Baksiyan G.A.

Burnasyan Federal Medical Biophysical Center

Zavialov A.A.

Burnasyan Federal Medical Biophysical Center

Voskanyan S.E.

Burnasyan Federal Medical Biophysical Center

Lishuk S.V.

Burnasyan Federal Medical Biophysical Center

Received:

23.02.2024

Accepted:

22.07.2024

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