STAS — четвертый механизм инвазии злокачественных опухолей легкого. Влияние на результаты лечения

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В мировой литературе возрос интерес к малоизученному механизму инвазии злокачественных опухолей легких, официально признанному ВОЗ лишь в 2015 г. Данный путь инвазии был назван STAS (spread through air spaces — распространение по воздушным пространствам). В настоящее время доказано, что феномен STAS значимо ухудшает течение злокачественных опухолей легких и коррелирует с частотой местных рецидивов после хирургического лечения особенно при выполнении сублобарных резекций. В статье освещено современное состояние проблемы, связанное с рецидивами после хирургического лечения злокачественных (первичных и вторичных) опухолей легких, обусловленными наличием в опухолях STAS-компонента инвазии. Изучение феномена STAS дополнит сложную картину карциногенеза в ткани легкого и позволит более осознанно подходить к вопросу хирургического лечения злокачественной патологии легких, в том числе и в сублобарном варианте.

Ключевые слова:

Spread through air spaces

STAS

распространение по воздушным пространствам

Авторы:

Баксиян Г.А.

ФГБУ ГНЦ «Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России

ORCID: 0000-0002-1367-4878

Завьялов А.А.

ФГБУ ГНЦ «Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России

ORCID: 0000-0003-1825-1871

Восканян С.Э.

ФГБУ ГНЦ «Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России

ORCID: 0000-0001-5691-5398

Лищук С.В.

ФГБУ ГНЦ «Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России

ORCID: 0000-0003-0372-5886

Дата поступления:

23.02.2024

Дата принятия в печать:

22.07.2024

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