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Khronenko V.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Zakharenkova Yu.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Varvarin V.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Sheremet D.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Shemetova M.M.

City Clinical Oncological Hospital No. 1 of the Moscow Department of Health

Sidorov D.V.

City Clinical Oncology Hospital One Moscow City Healthcare Department

Experience of perioperative anesthesiological support for successful ex situ, ex vivo liver resection, and autotransplantation in a patient with giant tumor of left liver lobe

Authors:

Khronenko V.E., Zakharenkova Yu.S., Varvarin V.V., Sheremet D.S., Shemetova M.M., Sidorov D.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2024;13(2): 46‑53

DOI: 10.17116/onkolog20241302146

Read: 945 times

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Table of contents

EXPERIENCE OF PERIOPERATIVE ANESTHESIOLOGICAL SUPPORT FOR SUCCESSFUL EX SITU, EX VIVO LIVER RESECTION, AND AUTOTRANSPLANTATION IN A PATIENT WITH GIANT TUMOR OF LEFT LIVER LOBE
EXPERIENCE OF PERIOPERATIVE ANESTHESIOLOGICAL SUPPORT FOR SUCCESSFUL EX SITU, EX VIVO LIVER RESECTION, AND AUTOTRANSPLANTATION IN A PATIENT WITH GIANT TUMOR OF LEFT LIVER LOBE

To cite this article:

Khronenko VE, Zakharenkova YuS, Varvarin VV, Sheremet DS, Shemetova MM, Sidorov DV. Experience of perioperative anesthesiological support for successful ex situ, ex vivo liver resection, and autotransplantation in a patient with giant tumor of left liver lobe. P.A. Herzen Journal of Oncology. 2024;13(2):46‑53. (In Russ.)
https://doi.org/10.17116/onkolog20241302146

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This article presents a clinical case of the first successful autotransplantation of the liver at the P.A. Herzen Moscow Oncological Research Institute, accompanied by massive blood loss and severe post-resection liver failure. The patient diagnosed with «stage IIIB hepatocellular carcinoma, T4N0M0» was admitted for surgical treatment. According to abdominal computed tomography, the left lobe of the liver was completely replaced by a lesion measuring 25x14x24 cm. Given the localization and spread of the tumor process, a decision was made to perform an extracorporeal stage of liver resection followed by autotransplantation. The intraoperative period was complicated by massive blood loss of 19.000 ml. In the early postoperative period, the patient was diagnosed with severe post-resection liver failure, requiring correction with extracorporeal detoxification methods (ultrahemodiafiltration, plasmapheresis). On the 17th day, the patient was transferred to a general ward in satisfactory condition and discharged from the clinic after 28 days.

Keywords:

liver autotransplantation
massive blood loss
post-resection liver failure

Authors:

Khronenko V.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Zakharenkova Yu.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Varvarin V.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Sheremet D.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Shemetova M.M.

City Clinical Oncological Hospital No. 1 of the Moscow Department of Health

Sidorov D.V.

City Clinical Oncology Hospital One Moscow City Healthcare Department

Received:

02.02.2023

Accepted:

05.05.2023

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References:

  1. Reddy SK, Barbas AS, Turley RS, Gamblin TC, Geller DA, Marsh JW, Tsung A, Clary BM, Lagoo-Deenadayalan S. Major liver resection in elderly patients: a multi-institutional analysis. J Am Coll Surg. 2011:212(5):787-795.  https://doi.org/10.1016/j.jamcollsurg.2010.12.048
  2. Vishnevskii VA, Fedorov VD, Podkolsin AV. Functional and morphological changes and liver regeneration after resection. Khirurgiya. 1993;(3):62-67. (In Russ.).
  3. Sviridova SP, Patyutko YuI, Gorozhanskaya EG, Simonova OV, Matveeva II. Post-resection liver failure in cancer patients. The Annals of Critical Care. 2010;(4):54-58. (In Russ.).
  4. Pichlmayr R, Grosse H, Hauss J, Gubernatis G, Lamesch P, Bretschneider HJ. Technique and preliminary results of extracorporeal liver surgery (bench procedure) and surgery on the in situ perfused liver. Br J Surg. 1990;77(1):21-26.  https://doi.org/10.1002/bjs.1800770107
  5. de Santibañes E, Cristiano A, de Santibañes, Yanzon A, Rodriguez Santos F, Ardiles V, Pekolj J. Ante-situm resection: a novel approach to avoid extracorporeal circulation using a transient portacaval shunt. HPB (Oxford). 2015;17(1):94-96.  https://doi.org/10.1111/hpb.12337
  6. McGilvray ID, Hemming AW. Ex vivo and in situ hypotermic hepatic resection. In: Jarnagin WR, ed. Blumgart’s surgery of the liver, biliary tract and pancreas. 6th ed. Section II. Elsevier Health Sciences; 2016;1670-1683.
  7. Mehrabi A, Fonouni H, Golriz M, Hofer S, Hafezi M, Rahbari NN, Weitz J, Büchler MW, Schmidt J. Hypothermic ante situm resection in tumors of the hepatocaval confluence. Dig Surg. 2011;28(2):100-108.  https://doi.org/10.1159/000323818
  8. Yamamoto Y. Ante-situm hepatic resection for tumors involving the confluence of hepatic veins and IVC. J Hepatobiliary Pancreat Sci. 2013;20(3):313-323.  https://doi.org/10.1007/s00534-012-0525-7
  9. Novruzbekov MS, Gulyaev VA, Olisov OD, Lutsyk KN, Akhmetshin RB, Magomedov KM, Kazymov BI, Donova LV, Muslimov RS. Extracorporeal resections and autotransplantation of the liver: an experience of 4 clinical cases. Annals of HPB Surgery. 2018;23(4):45-53. (In Russ.). https://doi.org/10.16931/1995-5464.2018445-53
  10. Shcherba AE, Kirkovskii LV, Dzyadz’ko AM, Avdei EL, Minov AF, Bolonkin LS, Rummo OO. Liver resection under hypothermic perfusion. Novosti Khirurgii. 2012;20(6):45-52. (In Russ.).
  11. Porte RJ, Molenaar IQ, Begliomini B, Groenland TH, Januszkiewicz A, Lindgren L, Palareti G, Hermans J, Terpstra OT. Aprotinin and transfusion requirements in orthotopic liver transplantation: a multicentre randomised double-blind study. EMSALT Study Group. Lancet. 2000;355(9212):1303-1309. https://doi.org/10.1016/s0140-6736(00)02111-5
  12. Khapii IKh, Lopatin AF, Malyutina LV. Efficacy and safety of using Tranexam in a surgical clinic. Effective Pharmacotherapy in Anesthesiology and Intensive Care. 2010;(1):24-28. (In Russ.).
  13. Minov AF, Dzyadz’ko AM, Rummo OO. Influence of the level of central venous pressure on the volume of blood loss and the need for transfusion in liver transplantation. Annals of Surgery. 2011;19(4):77-82. (In Russ.).
  14. Khokhar RS, Khan MM, Khan MU, Aqil M. Strategies to lower the central venous pressure during liver resections. Anaesth Pain Intensive Care. 2014;18(4):464-466. 
  15. Feltracco P, Brezzi ML, Barbieri S, Serra E, Milevoj M, Ori C. Epidural anesthesia and analgesia in liver resection and living donor hepatectomy. Transplant Proc. 2008;40(4):1165-1168. https://doi.org/10.1016/j.transproceed.2008.03.108
  16. Rekman J, Wherrett C, Bennett S, Gostimir M, Saeed S, Lemon K, Mimeault R, Balaa FK, Martel G. Safety and feasibility of phlebotomy with controlled hypovolemia to minimize blood loss in liver resections. Surgery. 2017;161(3):650-657.  https://doi.org/10.1016/j.surg.2016.08.026
  17. Khoronenko VE, Varvarin VV, Baskakov DS, Donskova YuS, Beresnev VA. The first experience with clinical use of terlipressin during surgery for liver cancer. P.A. Herzen Journal of Oncology. 2017;6(1):44-48. (In Russ.). https://doi.org/10.17116/onkolog20176144-48
  18. Cheng F, Yang Z, Zeng J, Gu J, Cu J, Ning J, Yi B. Anesthesia management of modified Ex Vivo liver resection and autotransplantation. Ann Transplant. 2018;23:274-284.  https://doi.org/10.12659/AOT.907796
  19. Zawistowski M, Nowaczyk J, Jakubczyk M, Domagała P. Outcomes of ex vivo liver resection and autotransplantation: a systematic review and meta-analysis. Surgery. 2020;168(4):631-642.  https://doi.org/10.1016/j.surg.2020.05.036
  20. Voskanyan SE, Onopriev VI, Artem’ev AI, Kostenko LL, Zabolotskikh IB, Danilyuk PI, Bol’bot EV. «Ex situ» and «In situ» autotransplantation of the liver in its unresectable primary and metastatic tumors. 2006;(2):76-77. (In Russ.).
  21. Oldhafer F, Ringe KI, Timrott K, Kleine M, Beetz O, Ramackers W, Cammann S, Klempnauer J, Vondran FWR, Bektas H. Modified ante situm liver resection without use of cold perfusion nor veno-venous bypass for treatment of hepatic lesions infiltrating the hepatocaval confluence. Langenbecks Arch Surg. 2018;403(3):379-386.  https://doi.org/10.1007/s00423-018-1658-1
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