Multiple primary synchronous tumors: features of modern diagnosis and treatment

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In recent decades, there has been an increase in the number of multiple primary malignant tumors. In the Russian Federation in 2021.10% of all newly diagnosed cases accounted for multiple primary tumors (58.217 cases). This is 2.12 times higher than for the same period in 2011 when 24.774 cases were recorded, constituting 4.7% of the total. Treatment of metachronous tumors often involves sequential treatment of each individual neoplasm and does not usually raise significant debates. Conversely, the treatment of synchronous tumors can be challenging. Despite advancements in cancer therapies, the issue of choosing a treatment strategy for synchronous tumors remains unresolved. There are still no unified clinical recommendations for treating this group of patients. Large randomized studies demonstrating the superiority of specific treatment methods and strategies are lacking in contemporary literature. This review analyzes the literature data on the methods used and the treatment outcomes in this group of patients.

Keywords:

multiple primary synchronous tumors

etiological factors of multiple primary malignancies

treatment of multiple primary synchronous tumors

Authors:

Titov K.S.

S.P. Botkin City Clinical Hospital Department of Healthcare of Moscow

ORCID: 0000-0003-4460-9136

Karpenko R.V.

S.P. Botkin City Clinical Hospital Department of Healthcare of Moscow

ORCID: 0009-0002-1086-7030

Lebedev S.S.

S.P. Botkin City Clinical Hospital

SPIN RSCI: 2736-0683
Scopus AuthorID: 7103044979
ORCID: 0000-0001-5366-1281

Grekov D.N.

S.P. Botkin City Clinical Hospital

ORCID: 0000-0001-8391-1210

Yakusheva T.A.

S.P. Botkin City Clinical Hospital

ORCID: 0009-0005-2715-3933

Received:

17.06.2023

Accepted:

26.07.2023

List of references:

Kaprin AD, Starinskii VV, Shakhzadova AO, eds. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2021 godu. M.: MNIOI im. P.A. Gertsena — filial FGBU «NMITs radiologii» Ministerstva zdravookhraneniya Rossiiskoi Federatsii; 2022;239. (In Russ.).
Chissov VI, Starinskii VV, Petrova GV, eds. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2011 godu. M.: FGBU «MNIOI im. P.A. Gertsena» Minzdravsotsrazvitiya Rossiiskoi Federatsii; 2012;240. (In Russ.).
Stepanova YuA, Kalinin DV, Vishnevskii VA. Primary multiple tumors (literature review). Meditsinskaya Vizualizatsiya. 2015;(6):93-102. (In Russ.).
Jensen OM, Storm HH, Jensen HS. Cancer registration in Denmark and the study of multiple primary cancers, 1943—80. Natl Cancer Inst Monogr. 1985;68:245-251.
Coleman MP. Multiple primary malignant neoplasms in England and Wales, 1971—1981. Yale J Biol Med. 1986;59(5):517-531.
Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T, Omlin A. Multiple primary tumours: challenges and approaches, a review. ESMO Open. 2017;2(2):e000172. https://doi.org/10.1136/esmoopen-2017-000172
Warren S. Multiple primary malignant tumors. A survey of the literature and a statistical study. Am J Cancer. 1932;16:1358-1414.
Chissov VI, Davydov MI, eds. Onkologiya. Natsional’noe rukovodstvo. M.: GEOTAR-media; 2008;1072. (In Russ.).
Minagawa Y. Trends in happy life expectancy in Russia, 1994—2015. SSM Popul Health. 2021;17:101005. https://doi.org/10.1016/j.ssmph.2021.101005
IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Personal habits and indoor combustions. Vol. 100e. A review of human carcinogens. Lyon, France: IARC Press; 2012;599.
Zaridze DG, Mukeriya AF. The effect of smoking on the prognosis of the disease in cancer patients. Voprosy Onkologii. 2019;65(3):321-329. (In Russ.).
Klyaritskaya IL, Is’kova IA. The role of alcohol in the development of gastrointestinal cancer. Krymskii Terapevticheskii Zhurnal. 2007;2(2):18-23. (In Russ.).
Dvoryaninova OYu, Choinzonov EL, Litvyakov NV. Clinical aspects of HPV-positive cancer of the oral cavity and oropharynx. Vestnik Oto-Rino-Laringologii. 2016;81(1):72-77. (In. Russ.). https://doi.org/10.17116/otorino201681172-77
Parkin DM, Bray F. Chapter 2: the burden of HPV-related cancers. Vaccine. 2006;24(suppl 3):S3/11-25. https://doi.org/10.1016/j.vaccine.2006.05.111
Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118(12):3030-3044. https://doi.org/10.1002/ijc.21731
Golmard L, Delnatte C, Laugé A, Moncoutier V, Lefol C, Abidallah K, Tenreiro H, Copigny F, Giraudeau M, Guy C, et al. Breast and ovarian cancer predisposition due to de novo BRCA1 and BRCA2 mutations. Oncogene. 2016;35(10):1324-1327. https://doi.org/10.1038/onc.2015.181
Stroganova AM, Pospekhova NI, Golovina DA, Cherepanova IS, Dranko SL, Filippova MG. Analysis of the results of long-term mass screening of mutations in the BRCA1/2 genes in patients with various types of malignant neoplasms. Russkii Meditsinskii Zhurnal. Meditsinskoe Obozrenie. 2022;6(6):297-308. (In Russ.). https://doi.org/10.32364/2587-6821-2022-6-6-297-308
Pan Z, Xie X. BRCA mutations in the manifestation and treatment of ovarian cancer. Oncotarget. 2017;8(57):97657-97670. https://doi.org/10.18632/oncotarget.18280
Godet I, Gilkes DM. BRCA1 and BRCA2 mutations and treatment strategies for breast cancer. Integr Cancer Sci Ther. 2017;4(1):10.15761/ICST.1000228. https://doi.org/10.15761/ICST.1000228
Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895—2015. Nat Rev Cancer. 2015;15(3):181-194. https://doi.org/10.1038/nrc3878
Giardiello FM, Allen JI, Axilband JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, et al. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. Dis Colon Rectum. 2014;57(8):1025-1048. https://doi.org/10.1097/DCR.000000000000000
Moreira L, Balaguer F, Lindor N, de la Chapelle A, Hampel H, Aaltonen LA, Hopper JL, Le Marchand L, Gallinger S, Newcomb PA, et al.; EPICOLON Consortium. Identification of Lynch syndrome among patients with colorectal cancer. JAMA. 2012;308(15):1555-1565. https://doi.org/10.1001/jama.2012.13088
Hampel H, Frankel W, Panescu J, Lockman J, Sotamaa K, Fix D, Comeras I, La Jeunesse J, Nakagawa H, Westman JA, et al. Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res. 2006;66(15):7810-7817. https://doi.org/10.1158/0008-5472.CAN-06-1114
Kratz CP, Freycon C, Maxwell KN, Nichols KE, Schiffman JD, Evans DG, Achatz MI, Savage SA, Weitzel JN, Garber JE, et al. Analysis of the Li-Fraumeni spectrum based on an International Germline TP53 Variant Data Set: an International Agency for Research on Cancer TP53 Database Analysis. JAMA Oncol. 2021;7(12):1800-1805. https://doi.org/10.1001/jamaoncol.2021.4398
Chittiboina P, Lonser RR. Von Hippel-Lindau disease. Handb Clin Neurol. 2015;132:139-156. https://doi.org/10.1016/B978-0-444-62702-5.00010-X
Goncharenko GV. Pervichno-mnozhestvennye zlokachestvennye opukholi naibolee rasprostranennykh lokalizatsii — statistika onkologicheskogo kabineta polikliniki. Research’n Practical Medicine Journal. 2015;2(4):59-65. (In Russ.). https://doi.org/10.17709/2409-2231-2015-2-4-59-65
Yang XB, Zhang LH, Xue JN, Wang YC, Yang X, Zhang N, Liu D, Wang YY, Xun ZY, Li YR, et al. High incidence combination of multiple primary malignant tumors of the digestive system. World J Gastroenterol. 2022;28(41):5982-5992. https://doi.org/10.3748/wjg.v28.i41.5982
Zhai C, Cai Y, Lou F, Liu Z, Xie J, Zhou X, Wang Z, Fang Y, Pan H, Han W. Multiple primary malignant tumors — a clinical analysis of 15,321 patients with malignancies at a single center in China. J Cancer. 2018;9(16):2795-2801. https://doi.org/10.7150/jca.25482
Jiao F, Yao LJ, Zhou J, Hu H, Wang LW. Clinical features of multiple primary malignancies: a retrospective analysis of 72 Chinese patients. Asian Pac J Cancer Prev. 2014;15(1):331-334. https://doi.org/10.7314/apjcp.2014.15.1.331
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
Trentham-Dietz A, Newcomb PA, Nichols HB, Hampton JM. Breast cancer risk factors and second primary malignancies among women with breast cancer. Breast Cancer Res Treat. 2007;105(2):195-207. https://doi.org/10.1007/s10549-006-9446-y
Qiu M, Lian YY, Lu M, Wang BS, Tian XJ, Lu J, Liu C, Zhang SD, Jiang M, Ma LL. [Treatment and prognosis of multiple primary malignant neoplasms complicated with renal cell carcinoma]. Beijing Da Xue Xue Bao Yi Xue Ban. 2022;54(4):680-685. (In Chinese). https://doi.org/10.19723/j.issn.1671-167X.2022.04.016
Skoropad VYu, Berdov BA. Results of treatment of primary multiple malignant tumors with localization of one of them in the stomach. Voprosy Onkologii. 2007;(3):298-303. (In Russ.).
Leonov OV, Dolgikh VT, Kopyl’tsov EI, Alekseev BYa. Primary multiple malignant neoplasms with lesions of the genitourinary organs. Onkourologiya. 2010;(2):56-60. (In Russ.).
Zeng QA, Qiu J, Zou R, Li Y, Li S, Li B, Huang P, Hong J, Zheng Y, Lao X, et al. Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: a long-term follow-up study. BMC Cancer. 2012;12:148. https://doi.org/10.1186/1471-2407-12-148

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