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Smetanina S.V.

Nizhny Novgorod Regional Clinical Oncology Center

Slavnova E.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Uskova E.Yu.

Nizhny Novgorod Regional Clinical Oncology Center

Orlinskaya N.Yu.

Volga Research Medical University of the Ministry of Health of the Russian Federation

Danyaeva M.B.

Nizhny Novgorod Regional Clinical Oncology Center

Khusiyanova A.A.

Nizhny Novgorod Regional Clinical Oncology Center

Cytological diagnosis of metastatic liver carcinomas

Authors:

Smetanina S.V., Slavnova E.N., Uskova E.Yu., Orlinskaya N.Yu., Danyaeva M.B., Khusiyanova A.A.

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Journal: P.A. Herzen Journal of Oncology. 2023;12(3): 27‑33

DOI: 10.17116/onkolog20231203127

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To cite this article:

Smetanina SV, Slavnova EN, Uskova EYu, Orlinskaya NYu, Danyaeva MB, Khusiyanova AA. Cytological diagnosis of metastatic liver carcinomas. P.A. Herzen Journal of Oncology. 2023;12(3):27‑33. (In Russ.)
https://doi.org/10.17116/onkolog20231203127

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Metastatic liver tumors exceed 30 times the primary cases of liver cancer. They occur in every third cancer patient, regardless of the location of the primary focus and account for up to 95% of all malignant liver lesions. Fine needle aspiration biopsy (FNAB) and core biopsy are widely used methods for obtaining diagnostic material from pathological liver foci.

OBJECTIVE

To improve the efficiency of morphological diagnosis of liver metastases using modern methods of sample preparation of biological material obtained by FNAB.

MATERIAL AND METHODS

The data of cytological and immunocytochemical studies from 386 patients with pathological foci in the liver were analyzed. Cellular material for the study was obtained in two ways: with the help of FNAB and by smear-imprint from the core-biopsy column. Cell blocks (BC) and liquid cytology (LC) were used as additional methods for studying cellular material.

RESULTS

In samples of FNAB, the frequency of obtaining non-informative material is almost two times less than in impression smears from core biopsy. FNAB makes it possible to apply the LC technique, thereby concentrating, enriching diagnostic material, and using CB in standard immunohistochemical (IHC) protocols. Reliability in determining the presence of liver metastases in the cytological study of smears-imprints from core biopsy material — 78.3%, FNAB with traditional cytology — 71.8%, FNAB with traditional cytology, LC and CB — 91.5%. The possibilities of cytology for determining the histological type of tumor have been expanded due to the introduction of immunocytochemical (ICC) studies.

CONCLUSION

Thus, taking into account the minimally invasiveness of FNAB, taking into account the existing limitations in core-biopsy, cytological verification of liver metastatic foci can be considered as a complete morphological method for verifying the primary lesion.

Keywords:

fine needle aspiration biopsy
metastatic liver carcinomas

Authors:

Smetanina S.V.

Nizhny Novgorod Regional Clinical Oncology Center

Slavnova E.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Uskova E.Yu.

Nizhny Novgorod Regional Clinical Oncology Center

Orlinskaya N.Yu.

Volga Research Medical University of the Ministry of Health of the Russian Federation

Danyaeva M.B.

Nizhny Novgorod Regional Clinical Oncology Center

Khusiyanova A.A.

Nizhny Novgorod Regional Clinical Oncology Center

Received:

20.08.2022

Accepted:

27.08.2022

List of references:

  1. Booth CM, Nanji S, Wei X, Mackillop WJ. Management and outcome of colorectal cancer liver metastases in elderly patients: a population-based study. JAMA Oncol. 2015;1(8):1111-1119. https://doi.org/10.1001/jamaoncol.2015.2943
  2. de Ridder J, de Wilt JH, Simmer F, Overbeek L, Lemmens V, Nagtegaal I. Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients. Oncotarget. 2016;7(34):55368-55376. https://doi.org/10.18632/oncotarget.10552
  3. Jones W, Allardice G, Scott I, Oien K, Brewster D, Morrison DS. Cancers of unknown primary diagnosed during hospitalization: a population-based study. BMC Cancer. 2017;17(1):85.  https://doi.org/10.1186/s12885-017-3083-1
  4. Finn RS. The role of liver biopsy in hepatocellular carcinoma. Gastroenterol Hepatol (N Y). 2016;12(10):628-630. 
  5. Silva MA, Hegab B, Hyde C, Guo B, Buckels JA, Mirza DF. Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis. Gut. 2008;57(11):1592-1596. https://doi.org/10.1136/gut.2008.149062
  6. Walia S, Aron M, Hu E, Chopra S. Utility of rapid on-site evaluation for needle core biopsies and fine-needle aspiration cytology done for diagnosis of mass lesions of the liver. J Am Soc Cytopathol. 2019;8(2):69-77.  https://doi.org/10.1016/j.jasc.2018.08.001
  7. McHugh KE, Policarpio-Nicolas Md MLC, Reynolds JP. Fine-needle aspiration of the liver: a 10-year single institution retrospective review. Hum Pathol. 2019;92:25-31.  https://doi.org/10.1016/j.humpath.2019.07.007
  8. Suo L, Chang R, Padmanabhan V, Jain S. For diagnosis of liver masses, fine-needle aspiration versus needle core biopsy: which is better? J Am Soc Cytopathol. 2018;7(1):46-49.  https://doi.org/10.1016/j.jasc.2017.09.004
  9. Huang SC, Liang JD, Hsu SJ, Hong TC, Yang HC, Kao JH. Direct comparison of biopsy techniques for hepatic malignancies. Clin Mol Hepatol. 2021;27(2):305-312.  https://doi.org/10.3350/cmh.2020.0301
  10. Buscarini L, Fornari F, Bolondi L, Colombo P, Livraghi T, Magnolfi F, Rapaccini GL, Salmi A. Ultrasound-guided fine-needle biopsy of focal liver lesions: techniques, diagnostic accuracy and complications. A retrospective study on 2091 biopsies. J Hepatol. 1990;11(3):344-348.  https://doi.org/10.1016/0168-8278(90)90219-h
  11. Fornari F, Filice C, Rapaccini GL, Caturelli E, Cavanna L, Civardi G, Di Stasi M, Buscarini E, Buscarini L. Small (< or = 3 cm) hepatic lesions. Results of sonographically guided fine-needle biopsy in 385 patients. Dig Dis Sci. 1994;39(10):2267-2275. https://doi.org/10.1007/BF02090383
  12. Stewart CJ, Coldewey J, Stewart IS. Comparison of fine needle aspiration cytology and needle core biopsy in the diagnosis of radiologically detected abdominal lesions. J Clin Pathol. 2002;55(2):93-97. 
  13. Rai SPV, Kumar VK, Basavaiah SH, Sreeram S, Gopal S, Tantry BV. Efficacy and validity of image-guided percutaneous fine needle aspiration and core biopsy of liver pathologies: saga of focal hepatic lesions from the nodule to the needle to the slide. J Cytol. 2021;38(1):21-30.  https://doi.org/10.4103/JOC.JOC_70_20
  14. Goldhoff PE, Vohra P, Kolli KP, Ljung BM. Fine-needle aspiration biopsy of liver lesions yields higher tumor fraction for molecular studies: a direct comparison with concurrent core needle biopsy. J Natl Compr Canc Netw. 2019;17(9):1075-1081. https://doi.org/10.6004/jnccn.2019.7300
  15. van Zante A, Ljung BM. Fine-needle aspiration versus core needle biopsy: reconsidering the evidence of superiority. Cancer Cytopathol. 2016;124(12):853-856.  https://doi.org/10.1002/cncy.21788
  16. Brachtel EF, Operaña TN, Sullivan PS, Kerr SE, Cherkis KA, Schroeder BE, Dry SM, Schnabel CA. Molecular classification of cancer with the 92-gene assay in cytology and limited tissue samples. Oncotarget. 2016;7(19):27220-27231. https://doi.org/10.18632/oncotarget.8449
  17. Roy-Chowdhuri S, Chen H, Singh RR, Krishnamurthy S, Patel KP, Routbort MJ, Manekia J, Barkoh BA, Yao H, Sabir S, et al. Concurrent fine needle aspirations and core needle biopsies: a comparative study of substrates for next-generation sequencing in solid organ malignancies. Mod Pathol. 2017;30(4):499-508.  https://doi.org/10.1038/modpathol.2016.228
  18. Shapiro NA. Tsitologicheskaya diagnostika zabolevanii legkikh. Vol. 2. M.: Reprotsentr M; 2005. (In Russ.).
  19. Shapiro NA, Batoroev JuK, Dvornichenko VV. Tsitologicheskaya diagnostika opukholei pecheni, zhelchnogo puzyrya i podzheludochnoi zhelezy. Vol. 9. M.: Reprotsentr M; 2012. (In Russ.).
  20. Lew M, Hissong EM, Westerhoff MA, Lamps LW. Optimizing small liver biopsy specimens: a combined cytopathology and surgical pathology perspective. J Am Soc Cytopathol. 2020;9(5):405-421.  https://doi.org/10.1016/j.jasc.2020.05.014
  21. Kumar VS, Sudhakar G. Study of fine needle aspiration cytology (FNAC) for diagnosis of lesions of liver diseases guided by ultra sound. IOSR JDMS. 2016;15(7):1-7. 
  22. Volchenko NN, Savostikova MV. Atlas tsitologicheskoi i immunotsitokhimicheskoi diagnostiki opukholi. M.: Reprotsentr M; 2010. (In Russ.).
  23. Geethamala K, Murthy VS, Vani BR, Rao MS, Thejaswini MU, Padmaja KP. Comparison of immunocytochemistry and immunohistochemistry on breast carcinoma: a boon or a bane? J Lab Physicians. 2017;9(1):5-10.  https://doi.org/10.4103/0974-2727.187915
  24. Selves J, Long-Mira E, Mathieu MC, Rochaix P, Ilié M. Immunohistochemistry for diagnosis of metastatic carcinomas of unknown primary site. Cancers (Basel). 2018;10(4):108.  https://doi.org/10.3390/cancers10040108
  25. Lukashina MI, Zhukova LG, Glukhova UI, Ozerova OA, Ermilova VD, Bogatyrev VN, Baryshnikov AYu. Sravnenie immunotsitokhimicheskogo i immunogistokhimicheskogo metodov opredeleniya biomarkerov pri rake molochnoi zhelezy. Klinicheskaya Laboratornaya Diagnostika. 2002;(8):37-40. (In Russ.).
  26. Mandal PK, Mondal SK, Roy S, Adhikari A, Basu N, Sinha SK. Immunocytochemistry: it’s role in diagnosis of undifferentiated neoplasms by fine needle aspiration cytology. J Cytol. 2013;30(2):121-124.  https://doi.org/10.4103/0970-9371.112656
  27. Roy S, Nandi A, Das I, Mandal PK. Comparative study of cytology and immunocytochemistry with trucut biopsy and immunohistochemistry in diagnosis of localized lung lesions: a prospective study. J Cytol. 2015;32(2): 90-95.  https://doi.org/10.4103/0970-9371.160557

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