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Polyakov A.P.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Filonenko E.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Reshetov I.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Nimatov E.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Ratushnyi M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Novikova I.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Mordovsky A.V.

Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Results of using intraoperative photodynamic therapy for locally advanced head and neck skin cancer

Authors:

Polyakov A.P., Filonenko E.V., Reshetov I.V., Nimatov E.E., Ratushnyi M.V., Novikova I.V., Mordovsky A.V.

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Journal: P.A. Herzen Journal of Oncology. 2023;12(3): 13‑19

DOI: 10.17116/onkolog20231203113

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Table of contents

RESULTS OF USING INTRAOPERATIVE PHOTODYNAMIC THERAPY FOR LOCALLY ADVANCED HEAD AND NECK SKIN CANCER
RESULTS OF USING INTRAOPERATIVE PHOTODYNAMIC THERAPY FOR LOCALLY ADVANCED HEAD AND NECK SKIN CANCER

To cite this article:

Polyakov AP, Filonenko EV, Reshetov IV, Nimatov EE, Ratushnyi MV, Novikova IV, Mordovsky AV. Results of using intraoperative photodynamic therapy for locally advanced head and neck skin cancer. P.A. Herzen Journal of Oncology. 2023;12(3):13‑19. (In Russ.)
https://doi.org/10.17116/onkolog20231203113

Подписка 2025-2 (P.A. Herzen Journal of Oncology)
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Recommended articles:
Use of intraoperative photodynamic therapy in surgical treatment of patients with recu­rrent loca­lly adva­nced head and neck skin cancer. P.A. Herzen Journal of Onco­logy. 2024;(6):12-17

OBJECTIVE

To improve the results of treatment in patients with primary and recurrent locally advanced basal cell cancer (BCC) and squamous cell cancer (SCC) of the head and neck skin, by using surgical treatments in combination with intraoperative photodynamic therapy.

SUBJECTS AND METHODS

The investigation enrolled 90 patients with primary and recurrent locally advanced cancer (T3, T4) of the head and neck skin. A study group of 45 patients received combination treatment: a surgical intervention and intraoperative photodynamic therapy with Photosens at a dose of 0.2 mg/kg; in the control group, 45 patients had surgical treatment only.

RESULTS

The median relapse-free survival in patients from the study group with squamous cell carcinoma (CC) of the head and neck skin cancer was 15 months; that in the control group was 8 months. At that time, the median overall survival was 52.0±2.1 months; while that in the control group was 20.0±2.0 months. The relapse-free survival rate in the study group with basal cell carcinoma (BCC) of the head and neck skin cancer was 40±2.4 moths; while that in the control group was 25±2.3 months. Overall survival in the study group was 88±2.7 months; whereas that in the control group was 40±2.4 moths. Intraoperative photodynamic therapy (PDDT) could increase overall and relapse-free survival rates.

CONCLUSION

Surgical treatment in combination with intraoperative photodynamic therapy (IOPDT) for locally advanced head and neck skin cancer could enhance the efficiency of treatment and achieve a reduction in tumor recurrence rates. Hence, intraoperative photodynamic therapy may be a method of choice to improve local control in the surgical treatment of locally advanced head and neck skin cancer.

Keywords:

locally advanced head and neck skin cancer
intraoperative photodynamic therapy

Authors:

Polyakov A.P.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Filonenko E.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Reshetov I.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Nimatov E.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Ratushnyi M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Novikova I.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Mordovsky A.V.

Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Received:

24.01.2023

Accepted:

27.01.2023

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