Standard lobectomy versus anatomic sublobar resection for peripheral T1-2N0M0 non-small cell lung cancer: comparative assessment of the survival-resection volume relationship

Levitsky A.V.; Chichevatov D.A.; Ter-Ovanesov M.D.; Sinev E.N.

doi:https://doi.org/10.17116/onkolog20211001124

Levitsky A.V.

City Clinical Hospital Forty;
Peoples’ Friendship University of Russia

Chichevatov D.A.

Regional Oncology Dispensary;
Medical Institute of the Penza State University

Ter-Ovanesov M.D.

City Clinical Hospital Forty

Sinev E.N.

Regional Oncology Dispensary

Standard lobectomy versus anatomic sublobar resection for peripheral T1-2N0M0 non-small cell lung cancer: comparative assessment of the survival-resection volume relationship

Authors:

Levitsky A.V., Chichevatov D.A., Ter-Ovanesov M.D., Sinev E.N.

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Journal: P.A. Herzen Journal of Oncology. 2021;10(1): 24‑30

DOI: 10.17116/onkolog20211001124

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To cite this article:

Levitsky AV, Chichevatov DA, Ter-Ovanesov MD, Sinev EN. Standard lobectomy versus anatomic sublobar resection for peripheral T1-2N0M0 non-small cell lung cancer: comparative assessment of the survival-resection volume relationship. P.A. Herzen Journal of Oncology. 2021;10(1):24‑30. (In Russ.)
https://doi.org/10.17116/onkolog20211001124

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To analyze the long-term results of treatment in patients who have been operated on as various volume variants of anatomical sublobar zonal resections and lobectomies for peripheral T1-2N0M0, Stage IA-IB, non-small cell solid cancer located in the large lobes of the lungs.

PATIENTS AND METHODS

The investigation enrolled 116 patients with peripheral T1-2N0M0 non-small cell lung cancer. All the patients were divided into 2 comparison groups: 1) 38 patients who had undergone surgery using anatomical sublobar zonal, or split-lobe, resections; 2) 78 patients who had standard lobectomy. The effectiveness of anatomical sublobar resection was evaluated.

RESULTS

There was no postoperative mortality in the compared groups. The overall progression rate was 18.4% (7/38) in Group 1 and 11.5% (9/78) in Group 2 (χ2=1.0; p=NS). At 28 months after surgery, there was a regional recurrence in the hilar lymph nodes of the remaining lung lobes only in 1 patient from Group 1. In all the other cases, the nature of progression was due to distant metastasis. There were no statistically significant differences in overall and disease-free survival between the groups. The 5-year overall survival rate was 74.8% in the sublobar resection group and 82% in the lobectomy one (p=0.369, log-rank test); the 5-year relapse-free survival rates were 76.2 and 85.2%, respectively (p=0.353, log-rank test).

CONCLUSION

In the surgical treatment of patients with T1-2N0M0 non-small cell peripheral lung cancer, lobectomies and anatomical sublobar resections as zonal, or split-lobe, resections demonstrate comparable long-term results. The standardization of this type of interventions needs additional investigations in the view.

Keywords:

non-small cell peripheral lung cancer

sublobar resection

sublobar zonal resection

split-lobe resection

Authors:

Levitsky A.V.

City Clinical Hospital Forty;
Peoples’ Friendship University of Russia

Chichevatov D.A.

Regional Oncology Dispensary;
Medical Institute of the Penza State University

Ter-Ovanesov M.D.

City Clinical Hospital Forty

Sinev E.N.

Regional Oncology Dispensary

Received:

18.08.2020

Accepted:

07.09.2020

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References:

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