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Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Sobolev D.D.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Pikin O.V.

Hertsen Moscow Oncology Research Institute

Kolobaev I.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Toigonbekov A.K.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Vindiza F.R.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Lymph node dissection along the recurrent laryngeal nerves for esophageal cancer. Technical aspects. Impact on short-term and long-term results

Authors:

Ryabov A.B., Khomyakov V.M., Sobolev D.D., Pikin O.V., Kolobaev I.V., Chayka A.V., Toigonbekov A.K., Vindiza F.R.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2020;9(5): 23‑30

DOI: 10.17116/onkolog2020905123

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Table of contents

LYMPH NODE DISSECTION ALONG THE RECURRENT LARYNGEAL NERVES FOR ESOPHAGEAL CANCER. TECHNICAL ASPECTS. IMPACT ON SHORT-TERM AND LONG-TERM RESULTS
LYMPH NODE DISSECTION ALONG THE RECURRENT LARYNGEAL NERVES FOR ESOPHAGEAL CANCER. TECHNICAL ASPECTS. IMPACT ON SHORT-TERM AND LONG-TERM RESULTS

To cite this article:

Ryabov AB, Khomyakov VM, Sobolev DD, et al. . Lymph node dissection along the recurrent laryngeal nerves for esophageal cancer. Technical aspects. Impact on short-term and long-term results. P.A. Herzen Journal of Oncology. 2020;9(5):23‑30. (In Russ.)
https://doi.org/10.17116/onkolog2020905123

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

OBJECTIVE

To evaluate the efficiency of lymph node dissection along the recurrent laryngeal nerves for esophageal squamous cell carcinoma.

MATERIAL AND METHODS

In 2014 to 2020, the Department of Thoracoabdominal Surgery, P.A. Herzen Moscow Oncology Research Institute, made 35 surgical interventions for middle thoracic esophageal cancer with extended lymphadenectomy along the recurrent laryngeal nerves: 16 patients were included in the group after neoadjuvant chemoradiation therapy and 19 cases of self-surgical treatment made up another group. The mean age of all the patients was 58 years. Squamous cell carcinoma and adenogenic cancer of the esophagus were diagnosed in 30 (85%) and 5 (15%) cases, respectively. Five (14%) cases were diagnosed with injury to the lymph nodes in the projection of the recurrent laryngeal nerve.

RESULTS

Ten (28%) patients were observed to have a complicated postoperative period. The postoperative period was complicated by pneumonia in 8 (23%) cases; in 3 (8%) cases of them, it was associated with vocal cord paresis. Injury to the recurrent laryngeal nerve was noted in a total of 6 (17%) cases in the study. The death rate in the group was 5%. At the moment, two of 5 patients, in whom a planned histological examination has revealed injury to the lymph nodes in the projection of the recurrent laryngeal nerve, remain to be followed up; the follow-up period is from 2 to 6 months. In the group of the patients operated on at the Institute, without using lymph node dissection along the recurrent laryngeal nerve, the overall 5-year survival rate was 38%.

CONCLUSION

The fundamental performance of lymphadenectomy along the recurrent laryngeal nerve, which is actively promoted by Asian surgeons, is currently one of the most urgent areas in the surgery of esophageal squamous cell carcinoma. The globally accumulated experience with operations and the standardization of the technique have made it possible to considerably increase the safety of this stage of surgical intervention. Nevertheless, now there is no unambiguous answer to the question of whether lymph node dissection improves the long-term results of surgical and combined treatments in the European population, which necessitates recruitment and an analysis of one’s own material during clinical trials.

Keywords:

esophageal cancer
surgical treatment for esophageal cancer
combined treatment for esophageal cancer
lymph node dissection along the recurrent laryngeal nerves

Authors:

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Sobolev D.D.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Pikin O.V.

Hertsen Moscow Oncology Research Institute

Kolobaev I.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Toigonbekov A.K.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Vindiza F.R.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Received:

09.07.2020

Accepted:

19.07.2020

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References:

  1. DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS, Jemal A. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252-271.  https://doi.org/10.3322/caac.21235
  2. Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of esophageal cancer by histological subtype in 2012. Gut. 2015;64(3)381-387.  https://doi.org/10.1136/gutjnl-2014-308124
  3. Kaprin AD, Starinsky VV, Petrova GV, eds. Malignant neoplasms in Russia in 2018 (morbidity and mortality). M.: MNIOI imeni P.A. Gertsena — filial FGBU «NMITs radiologii» Minzdrava Rossii; 2019. (In Russ.).
  4. Sobolev DD, Mamontov AS, Khomyakov VM, Vashakmadze LA, Ryabov AB, Cheremisov VV, Kolobaev IV, Chaika AV, Boiko AV, Vindiza FR, Kuznetsova OS. Results of surgical and combined treatment in patients with thoracic esophageal carcinoma: Ten-year experience of the P.A. Herzen Moscow Oncology Research Institute. Herzen Journal of Oncology/Onkologiya. Zhurnal imeni P.A. Gertsena. 2018;7(4):4-14. (In Russ.). https://doi.org/10.17116/onkolog2018744
  5. Altorki N, Kent M, Ferrara C, Port J. Three-field lymph node dissection for squamous cell and adenocarcinoma of the esophagus. Ann Surg. 2002;236(2):177-183.  https://doi.org/10.1097/00000658-200208000-00005
  6. Luketich JD, Pennathur A, Awais O, Levy RM, Keeley S, Shende M, Christie NA, Weksler B, Landreneau RJ, Abbas G, Schuchert MJ, Nason KS. Outcomes after minimally invasive esophagectomy review of over 1000 patients. Ann Surg. 2012;256(1):95-103.  https://doi.org/10.1097/sla.0b013e3182590603
  7. Udagawa H, Akiyama H. Surgical treatment of esophageal cancer: Tokyo experience of the three-field technique. Dis Esophagus. 2001;14(2):110-114.  https://doi.org/10.1046/j.1442-2050.2001.00166.x
  8. Akiyama H, Tsurumaru M, Udagawa H, Kajiyama Y. Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg. 1994;220(3):364-372.  https://doi.org/10.1097/00000658-199409000-00012
  9. Akagawa S, Hosogi H, Yoshimura F, Kawada H, Kanaya S. Mesenteric excision for esophageal cancer surgery: based on the concept of mesotracheoesophagus. Int Cancer Conf J. 2018;7(4):117-120.  https://doi.org/10.1007/s13691-018-0329-y
  10. Palanivelu C, Prakash A, Senthilkumar R, Senthilnathan P, Parthasarathi R, Rajan PS, Venkatachlam S. Minimally invasive esophagectomy: Thoracoscopic mobilization of the esophagus and mediastinal lymphadenectomy in prone position — Experience of 130 patients. J Am Coll Surg. 2006;203(1):7-16.  https://doi.org/10.1016/j.jamcollsurg.2006.03.016
  11. Xi Y, Ma Z, Shen Y, Wang H, Feng M, Tan L, Wang Q. A novel method for lymphadenectomy along the left laryngeal recurrent nerve during thoracoscopic esophagectomy for esophageal carcinoma. J Thorac Dis. 2016;8(1):24-30.  https://doi.org/10.3748/wjg.v26.i12.1340
  12. Milsom J, Trencheva K, Monette S, Pavoor R, Shukla P, Ma J, Sonoda T. Evaluation of the safety, efficacy, andversatility of a new surgical energy device (THUNDER-BEAT) in comparison with Harmonic ACE, LigaSure V, and EnSeal devices in a porcine model. J Laparoendosc Adv Surg Tech A. 2012;22(4):378-386.  https://doi.org/10.1089/lap.2011.0420
  13. Zheng B, Han ZY, Chen C. Esophageal suspension method in scavenging peripheral lymph nodes of the left recurrent laryngeal nerve in thoracic esophageal carcinoma through semi-prone-position thoracoscopy. J Cancer Res Ther. 2014;10(4):985-990.  https://doi.org/10.4103/0973-1482.144354
  14. Makino H, Nomura T, Miyashita M, Okawa K, Hagiwara N, Uchida E. Esophageal stripping creates a clear operative field for lymph node dissection along the left recurrent laryngeal nerve in prone video-assisted thoracoscopic surgery. J Nippon Med School. 2011;78(3):199-204.  https://doi.org/10.1272/jnms.78.199
  15. Oshikiri T, Yasuda T, Harada H, Goto H, Oyama M, Hasegawa H, Ohara T, Sendo H, Nakamura T, Fujino Y, Tominaga M, Kakeji Y. A new method (the «Bascule method») for lymphadenectomy along the left recurrent laryngeal nerve during prone esophagectomy for esophageal cancer. Surg Endosc. 2015;29(8):2442-2250. https://doi.org/10.1007/s00464-014-3919-6
  16. Noshiro H, Iwasaki H, Kobayashi K, Uchiyama A, Miyasaka Y, Masatsugu T, Koike K, Miyazaki K. Lymphadenectomy along the left recurrent laryngeal nerve by a minimally invasive esophagectomy in the prone position for thoracic esophageal cancer. Surg Endosc. 2010;24(12):2965-2973. https://doi.org/10.1007/s00464-010-1072-4
  17. Suda K, Ishida Y, Kawamura Y, Inaba K, Kanaya S, Termukai S, Satoh S, Uyama I. Robot-assisted thoracoscopic lymphadenectomy along the left recurrent laryngeal nerve for esophageal squamous cell carcinoma in the prone position: technical report and short-term outcomes. World J Surg. 2012;36(7):1608-1166. https://doi.org/10.1007/s00268-012-1538-8
  18. Dhamija A, Rosen JE, Dhamija A, Gould Rothberg BE, Kim AW, Detterbeck FC, Boffa DJ. Learning curve to lymph node resection in minimally invasive esophagectomy for cancer. Innovations (Phila). 2014;9(4):286-291.  https://doi.org/10.1097/imi.0000000000000082
  19. Wong I, Tong DKH, Tsang RKY, Wong CLY, Chan DKK, Chan FSY, Law S. Continuous intraoperative vagus nerve stimulation for monitoring of recurrent laryngeal nerve during minimally invasive esophagectomy. J Vis Surg. 2017;3(9):1-7.  https://doi.org/10.1016/s0016-5085(17)34210-5
  20. Ye K, Xu JH, Sun YF, Lin JA, Zheng ZG. Characteristics and clinical significance of lymph node metastases near the recurrent laryngeal nerve from thoracic esophageal carcinoma. Genet Mol Res. 2014;13(3):6411-6419. https://doi.org/10.4238/2014.August.25.4
  21. Hulscher JB, van Sandick JW, Tijssen JG, Obertop H, van Lanschot JJ. The recurrence pattern of esophageal carcinoma after transhiatal resection. J Am Coll Surg. 2000;191(2):143-148.  https://doi.org/10.1016/s1072-7515(00)00349-5
  22. Clark GW, Peters JH, Ireland AP, Ehsan A, Hagen JA, Kiyabu MT, Bremner CG, DeMeester TR. Nodal metastasis and sites of recurrence after en bloc esophagectomy for adenocarcinoma. Ann Thorac Surg. 1994;58(3):646-653.  https://doi.org/10.1016/0003-4975(94)90722-6
  23. Makino H, Yoshida H, Uchida E. Lymph node dissection along the recurrent laryngeal nerve in video-assisted thoracoscopic surgery (VATSE) for esophageal squamous cell carcinoma. In: Jianyuan Chai, ed. Esophageal abnormalities. 2017. https://doi.org/10.5772/intechopen.69524
  24. Makino H, Yoshida H, Maruyama H, Yokoyama T, Hirakata A, Ueda J, Takada H, Matsutani T, Nomura T, Hagiwara N, Uchida E. An original technique for lymph node dissection along the left recurrent laryngeal nerve after stripping the residual esophagus during video-assisted thoracoscopic surgery of esophagus. J Vis Surg. 2016;2:166.  https://doi.org/10.21037/jovs.2016.11.01
  25. Orringer MB, Marshall B, Stirling MC. Transhiatal esophagectomy for benign and malignant disease. J Thorac Cardiovasc Surg. 1993;105:265-276.  https://doi.org/10.1016/s0022-5223(19)33811-5
  26. Feinstein AR, Sosin DM, Wells CK. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med. 1985; 312(25):1604-1608. https://doi.org/10.1056/nejm198506203122504
  27. Tapias LF, Morse CR. Minimally invasive Ivor Lewis esophagectomy: description of a learning curve. J Am Coll Surg. 2014; 218(6):1130-1140. https://doi.org/10.1016/j.jamcollsurg.2014.02.014
  28. Dresner SM, Wayman J, Shenfine J, Harris A, Hayes N, Griffin SM. Pattern of recurrence following subtotal oesophagectomy with two field lymphadenectomy. Br J Surg. 2000;87(3):362-273.  https://doi.org/10.1046/j.1365-2168.2000.01541.x
  29. Tachibana M, Kinugasa S, Yoshimura H, Dhar DK, Nagasue N. Extended esophagectomy with 3-field lymph node dissection for esophageal cancer. Arch Surg. 2003;138(12):1383-1389; discussion 1390. https://doi.org/10.1001/archsurg.138.12.1383
  30. Igaki H, Tachimori Y, Kato H. Improved survival for patients with upper and/or middle mediastinal lymph node metastasis of squamous cell carcinoma of the lower thoracic esophagus treated with 3-field dissection. Ann Surg. 2004;239(4):483-490.  https://doi.org/10.1097/01.sla.0000118562.97742.29
  31. Lerut T, Nafteux P, Moons J, Coosemans W, Decker G, De Leyn P, Van Raemdonck D, Ectors N. Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg. 2004;240(6):962-974.  https://doi.org/10.1097/01.sla.0000145925.70409.d7
  32. Sasako M, McCulloch P, Kinoshita T, Maruyama K. New method to evaluate the therapeutic value of lymph node dissection for gastric cancer. Br J Surg. 1995;82(3):346-351.  https://doi.org/10.1002/bjs.1800820321
  33. Udagawa H, Ueno M, Shinohara H, Haruta S, Kaida S, Nakagawa M, Tsurumaru M. The importance of grouping of lymph node stations and rationale of three-field lymphoadenectomy for thoracic esophageal cancer. J Surg Oncol. 2012;106( 6):742-747.  https://doi.org/10.1002/jso.23122
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