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Sergeeva N.S.
Russian University of Peoples' Friendship
Marshutina N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Solokhina M.P.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Alentov I.I.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Poljakov A.P.
FGBU «Moskovskiĭ nauchno-issledovatelskiĭ onkologicheskiĭ institut im. P.A. Gertsena» Minzdrava Rossii
Gevorkov A.R.
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia, Moscow, Russian Federation
Pirogov S.S.
P.A. Gertsen Moscow Research Oncological Institute affiliated with the National Medical Research Centre of Radiology, Ministry of Health of the Russia, Russia
Khomyakov V.M.
Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia
Kaprin A.D.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Epstein—Barr virus-associated solid malignancies
Journal: P.A. Herzen Journal of Oncology. 2018;7(5): 80‑89
Read: 10718 times
To cite this article:
Sergeeva NS, Marshutina NV, Solokhina MP, et al. . Epstein—Barr virus-associated solid malignancies. P.A. Herzen Journal of Oncology.
2018;7(5):80‑89. (In Russ.)
https://doi.org/10.17116/onkolog2018705180
The review provides information on Epstein—Barr virus (EBV) and describes the functions of its main marker molecules: six types of EBV nuclear antigen (EBNA), nuclear BARF1 protein, members of the family of latent membrane proteins (LMP) (LMP-1, LMP-2A, and LMP-2B), EBV-encoded small RNAs (EBERs), microRNA from the BART and BHRF1 regions of the virus genome. The review also gives the data available in the literature on the frequency of clinico-morphological and molecular biological characteristics of EBV-associated gastric cancer (EBV+GC) and nasopharyngeal cancer (EBV+NPC), as well as on the role of EBV in the etiopathogenesis of these tumors. It considers methods for specifying the diagnosis of EBV-associated diseases on the basis of molecular genetic markers of the virus and for determining a number of antibodies to viral proteins. Whether it is expedient to determine circulating EBV DNA in the monitoring of patients with EBV+NPC for the evaluation of the efficiency of treatment and preclinical detection of relapses is discussed.
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Authors:
Sergeeva N.S.
Russian University of Peoples' Friendship
Marshutina N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Solokhina M.P.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Alentov I.I.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Poljakov A.P.
FGBU «Moskovskiĭ nauchno-issledovatelskiĭ onkologicheskiĭ institut im. P.A. Gertsena» Minzdrava Rossii
Gevorkov A.R.
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia, Moscow, Russian Federation
Pirogov S.S.
P.A. Gertsen Moscow Research Oncological Institute affiliated with the National Medical Research Centre of Radiology, Ministry of Health of the Russia, Russia
Khomyakov V.M.
Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia
Kaprin A.D.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
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