Epstein—Barr virus-associated solid malignancies

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Features of the inflammatory process in the gastric mucosa with bacterial and viral co-infection. Russian Journal of Evidence-Based Gastroenterology. 2024;(3):13-19

The review provides information on Epstein—Barr virus (EBV) and describes the functions of its main marker molecules: six types of EBV nuclear antigen (EBNA), nuclear BARF1 protein, members of the family of latent membrane proteins (LMP) (LMP-1, LMP-2A, and LMP-2B), EBV-encoded small RNAs (EBERs), microRNA from the BART and BHRF1 regions of the virus genome. The review also gives the data available in the literature on the frequency of clinico-morphological and molecular biological characteristics of EBV-associated gastric cancer (EBV+GC) and nasopharyngeal cancer (EBV+NPC), as well as on the role of EBV in the etiopathogenesis of these tumors. It considers methods for specifying the diagnosis of EBV-associated diseases on the basis of molecular genetic markers of the virus and for determining a number of antibodies to viral proteins. Whether it is expedient to determine circulating EBV DNA in the monitoring of patients with EBV+NPC for the evaluation of the efficiency of treatment and preclinical detection of relapses is discussed.

Keywords:

Epstein—Barr virus

forms of latent virus carriage

EBV-associated gastric cancer

EBV-associated nasopharyngeal cancer

Authors:

Sergeeva N.S.

Russian University of Peoples' Friendship

Marshutina N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Solokhina M.P.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Alentov I.I.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Poljakov A.P.

FGBU «Moskovskiĭ nauchno-issledovatelskiĭ onkologicheskiĭ institut im. P.A. Gertsena» Minzdrava Rossii

Gevorkov A.R.

P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia, Moscow, Russian Federation

Pirogov S.S.

P.A. Gertsen Moscow Research Oncological Institute affiliated with the National Medical Research Centre of Radiology, Ministry of Health of the Russia, Russia

Khomyakov V.M.

Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

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