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Abuzarova G.R.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Sarmanaeva R.R.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Lapina S.E.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Kuznetsov S.V.

P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia, Moscow

Strong opioid analgesics in therapy for chronic pain syndrome. Which drug should be preferred?

Authors:

Abuzarova G.R., Sarmanaeva R.R., Lapina S.E., Kuznetsov S.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2017;6(6): 62‑71

DOI: 10.17116/onkolog20176662-71

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To cite this article:

Abuzarova GR, Sarmanaeva RR, Lapina SE, Kuznetsov SV. Strong opioid analgesics in therapy for chronic pain syndrome. Which drug should be preferred?. P.A. Herzen Journal of Oncology. 2017;6(6):62‑71. (In Russ.)
https://doi.org/10.17116/onkolog20176662-71

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According to current Russian recommendations for pain therapy in palliative patients, the use of opioid analgesics is justified as necessary in treating chronic pain syndrome (CPS). However, the side effects of the agents, which accompany opioid therapy, often limit their efficacy and reduce quality of life in patients. Until recently, there have been only two highly potent opioid drugs, such as morphine (tablets, capsules) and TTS fentanyl, to treat severe CPS in our practice. A third drug (oxycodone/naloxone) has been available since 2017. The review considers indications for the use of this or that drug in terms of their pharmacokinetics and metabolism, their characteristics of their dosage forms, and foreign experience of their use.

Keywords:

chronic pain therapy
strong opioid analgesics
pharmacology
clinical application

Authors:

Abuzarova G.R.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Sarmanaeva R.R.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Lapina S.E.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Kuznetsov S.V.

P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia, Moscow

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