The review summarizes data on the in vitro effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of a number of genes, the proliferation and apoptosis of a number of tumor cell cultures, and the growth of transplantable human malignant tumor cell lines. of human malignant neoplasms. It gives data on the effect of NSAIDs in colorectal cancer and recurrent breast cancer. There is evidence for the safety and expediency of using NDAIDs in replacement of bone tissue after surgical removal of bony metastases in cancer patients.