Different procedures to prepare liquid-based cytology agents (CytoSpin3, E-Prep Processor, and BD TriPath) and traditional smears were compared. The material under investigation was obtained from 112 patients with a pathological process at different sites: exudates (n=31), tumors of bone and soft tissue (n=22), lymph nodes (n=18), breast (n=20), salivary glands (n=7), lung (n=9), and thyroid (n=5). When liquid-based and traditional smear cytologies were concurrently used, the efficiency of cytological examination increased by 3.3-5.0%. The use of all liquid procedures allowed immunocytochemical examination; and the clear background and concentration of pathological cells in the small smear window improved the assessment of a reaction.