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Zhilinskaya I.N.

Research Institute of Influenza named after A.A. Smorodintsev;
North-Western State Medical University Named after I.I. Mechnikov

Marchenko V.A.

Clinic «Doctor Prof»

Kharchenko E.P.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Comparison of fragments in human hemostatic proteins that mimics fragments in proteins of A/H1N1 viruses and coronaviruses

Authors:

Zhilinskaya I.N., Marchenko V.A., Kharchenko E.P.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2022;40(4): 43‑46

DOI: 10.17116/molgen20224004143

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Table of contents

COMPARISON OF FRAGMENTS IN HUMAN HEMOSTATIC PROTEINS THAT MIMICS FRAGMENTS IN PROTEINS OF A/H1N1 VIRUSES AND CORONAVIRUSES
COMPARISON OF FRAGMENTS IN HUMAN HEMOSTATIC PROTEINS THAT MIMICS FRAGMENTS IN PROTEINS OF A/H1N1 VIRUSES AND CORONAVIRUSES

To cite this article:

Zhilinskaya IN, Marchenko VA, Kharchenko EP. Comparison of fragments in human hemostatic proteins that mimics fragments in proteins of A/H1N1 viruses and coronaviruses. Molecular Genetics, Microbiology and Virology. 2022;40(4):43‑46. (In Russ.)
https://doi.org/10.17116/molgen20224004143

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To compare the repertoire of proteins of the human hemostasis system and fragments mimicking these proteins in the proteins of influenza A/H1N1 viruses and coronaviruses.

MATERIAL AND METHODS

Influenza viruses A/H1N1 (A/Brevig Mission/1/18), A/St. Petersburg /RII04/2016 (H1N1)pdm09, coronaviruses SARS-CoV and SARS-CoV-2 (strain Wuhan-Hu-1) were used for comparative computer analysis. The sources of the primary structures of proteins of the analyzed viruses and 41 proteins of the human hemostasis system were publicly available Internet databases, respectively, www.ncbi.nlm.nih.gov and www.nextprot.org. The search for homologous sequences in the structure of viral proteins and hemostasis proteins was carried out by comparing fragments of 12 amino acids in length, taking as related those that showed identity at ≥ 8 positions.

RESULTS

Comparative analysis of the repertoire of cellular proteins of the hemostasis system and fragments mimicking these proteins in the structure of proteins of viruses A/H1N1 1918, A(H1N1)pdm09 2016, SARS-CoV and SARS-CoV-2, showed a significant difference between SARS-CoV-2 and analyzed viruses. In the protein structure of the SARS-CoV-2 virus, mimicry was revealed for almost all analyzed hemostasis proteins. As for the comparison of viruses A/H1N1 1918, A(H1N1)pdm09 2016 and SARS-CoV, the influenza virus A/H1N1 1918 and SARS-CoV are the closest in the repertoire of hemostasis proteins.

CONCLUSION

Obtained bioinformatic analysis data can serve as a basis for further study of the role of homologous fragments in the regulation of hemostasis of the host organism.

Keywords:

viral proteins
proteins of the human hemostasis system
primary structure of proteins

Authors:

Zhilinskaya I.N.

Research Institute of Influenza named after A.A. Smorodintsev;
North-Western State Medical University Named after I.I. Mechnikov

Marchenko V.A.

Clinic «Doctor Prof»

Kharchenko E.P.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Received:

17.11.2021

Accepted:

20.05.2022

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References:

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