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Lunina N.A.

Institute of Molecular Genetics of National Research Centre «Kurchatov Institute»

Safina D.R.

Kazan Federal University

Intercellular interactions in the tumor stroma and their role in oncogenesis

Authors:

Lunina N.A., Safina D.R.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2022;40(4): 3‑8

DOI: 10.17116/molgen2022400413

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To cite this article:

Lunina NA, Safina DR. Intercellular interactions in the tumor stroma and their role in oncogenesis. Molecular Genetics, Microbiology and Virology. 2022;40(4):3‑8. (In Russ.)
https://doi.org/10.17116/molgen2022400413

 
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Cancer remains the second leading cause of death in the world, despite significant improvements in diagnosis and therapy. This is partly due to the fact that most of the therapeutics developed were aimed at tumor cells, ignoring the tumor microenvironment. Currently, there is an increased interest in understanding the role of the microenvironment in tumor growth and progression, which has prompted a new paradigm of cancer treatment: targeting the tumor stroma. The stroma can make up more than 50% of the mass of the tumor node and coordinate proliferation, local invasion and, eventually, metastasis of cancer cells into surrounding tissues. Stroma includes extracellular matrix, immune cells, tumor vascular network, fibroblasts, neuroendocrine cells and fat cells. Malignant cells recruit stromal cells to remodel the tissue structure and isolate growth stimuli and intermediate metabolites. As a result, stromal components contribute to multiple processes of oncogenesis, which include tumor growth, invasion, metastasis and resistance to therapy. Cancer-associated fibroblasts play an important role in these processes. This review examines the main mechanisms of intercellular interactions in the tumor stroma, including their regulation and role in oncogenesis.

Keywords:

tumor stroma
tumor microenvironment
intercellular communication
cancer-associated fibroblasts
oncogenesis

Authors:

Lunina N.A.

Institute of Molecular Genetics of National Research Centre «Kurchatov Institute»

Safina D.R.

Kazan Federal University

Received:

03.10.2022

Accepted:

30.10.2022

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