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Ermolaeva S.A.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia;
Nizhny Novgorod Scientific Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Bespalova T.Yu.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Mikhaleva T.V.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Kustikova O.V.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Sysolyatina E.V.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia

Vasilieva E.V.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia

Chalenko Ya.M.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia;
Nizhny Novgorod Scientific Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

How to move from cell to cell without leaving the intracellular space: lessons from intracellular parasites

Authors:

Ermolaeva S.A., Bespalova T.Yu., Mikhaleva T.V., Kustikova O.V., Sysolyatina E.V., Vasilieva E.V., Chalenko Ya.M.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2021;39(1): 3‑11

DOI: 10.17116/molgen2021390113

Views: 6141

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To cite this article:

Ermolaeva SA, Bespalova TYu, Mikhaleva TV, Kustikova OV, Sysolyatina EV, Vasilieva EV, Chalenko YaM. How to move from cell to cell without leaving the intracellular space: lessons from intracellular parasites. Molecular Genetics, Microbiology and Virology. 2021;39(1):3‑11. (In Russ.)
https://doi.org/10.17116/molgen2021390113

 
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Intracellular parasites play an important role in human infectious diseases. Pathogenic bacteria of four genera, Shigella, Listeria, Rickettsia, and Burkholderia, developed a similar strategy for intracellular reproduction and dissemination inside tissues and organs: these bacteria destroy the phagosome to multiply in the cytoplasm, and spread from cell to cell without leaving the intracellular space. For intracellular and intercellular movement, these bacteria use convergently developed mechanisms that control synthesis of actin microfilaments, which are elements of the host cell cytoskeleton. The review discusses molecular mechanisms underlying the polymerization of actin microfilaments on the surface of bacteria and the bacterial spreading from cell to cell. It also discusses what reasons may necessitate the development of mechanisms of movement using actin microfilaments, and the potential of proteins that provide intracellular and intercellular movement as a target for the development of new antimicrobial agents.

Keywords:

intracellular parasitism
intracellular movement
spreading from cell to cell
actin polymerization
convergent evolution

Authors:

Ermolaeva S.A.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia;
Nizhny Novgorod Scientific Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Bespalova T.Yu.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Mikhaleva T.V.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Kustikova O.V.

Samara Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Sysolyatina E.V.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia

Vasilieva E.V.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia

Chalenko Ya.M.

National Research Center for Epidemiology and Microbiology named after N.F. Gamalei Ministry of Health of Russia;
Nizhny Novgorod Scientific Research Veterinary Institute — branch of Federal Research Center of Virology and Microbiology

Received:

15.04.2020

Accepted:

15.06.2020

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