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Melnichuk O.S.

Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Statsenko L.V.

St. Joasaph Belgorod Regional Clinical Hospital

Lyalyakina E.V.

Ivanovo Regional Clinical Hospital

Kokareva T.S.

Kirov Regional Clinical Hospital

Timofeeva I.V.

City Clinical Hospital No. 7

Chausova S.V.

Pirogov Russian National Research Medical University

Kulichenko T.V.

Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
National Research Medical Center for Pediatrics — Pirogov Russian National Research Medical University

Mayansky N.A.

Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Indirect reference intervals of six hemogram parameters calculated from hospital data

Authors:

Melnichuk O.S., Statsenko L.V., Lyalyakina E.V., Kokareva T.S., Timofeeva I.V., Chausova S.V., Kulichenko T.V., Mayansky N.A.

More about the authors

Journal: Laboratory Service. 2023;12(2): 26‑32

DOI: 10.17116/labs20231202126

Views: 431

Downloaded: 12

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To cite this article:

Melnichuk OS, Statsenko LV, Lyalyakina EV, et al. . Indirect reference intervals of six hemogram parameters calculated from hospital data. Laboratory Service. 2023;12(2):26‑32. (In Russ.)
https://doi.org/10.17116/labs20231202126

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In recent years, various indirect methods and their modifications have been actively used to calculate reference intervals (RI), which allow analyzing large amounts of laboratory data.

OBJECTIVE

Calculate the RI of hemogram parameters in children using the indirect refineR method.

MATERIAL AND METHODS

Anonymized data for the calculation of RI were obtained from laboratories from medical institutions in Belgorod, Ivanovo, Kirov and Tolyatti. The calculations included only results obtained from analyzers of the Sysmex family (5-DIFF) in children aged 1 to 18 years. RI was calculated for the total number of leukocytes, the absolute number of lymphocytes, neutrophils, monocytes, hemoglobin and the number of platelets for three age groups: 1—5 years, 5—10 years, 10—18 years.

RESULTS

A total of 94 972 hemograms were included in the calculations. The structure of the data source: outpatients — 60 287 (63%), hospital — 30 062 (32%), day hospital — 3543 (3.7%), medical examinations — 1080 (1.3%). The region did not affect the hemogram parameters within the age groups, which made it possible to combine the data for the calculation of RI. The age dynamics of the analyzed indicators according to hospital data corresponded to the physiological characteristics of various periods of childhood. In the age group 10—18 years, RIs were divided by sex for hemoglobin (boys 121—170 g/l, girls 115—150 g/l), platelet counts (boys 176—424·109/l, girls 182—431·109/l). RI of other indicators was calculated regardless of gender.

CONCLUSION

The refineR method can be used to develop pediatric RIs of hemograms by an indirect method.

Keywords:

indirect reference intervals
hemogram
children

Authors:

Melnichuk O.S.

Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Statsenko L.V.

St. Joasaph Belgorod Regional Clinical Hospital

Lyalyakina E.V.

Ivanovo Regional Clinical Hospital

Kokareva T.S.

Kirov Regional Clinical Hospital

Timofeeva I.V.

City Clinical Hospital No. 7

Chausova S.V.

Pirogov Russian National Research Medical University

Kulichenko T.V.

Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
National Research Medical Center for Pediatrics — Pirogov Russian National Research Medical University

Mayansky N.A.

Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Received:

19.06.2023

Accepted:

28.06.2023

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