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Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Dmitriev G.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Gabrichevsky Institute Of Epidemiology And Microbiology

Kitaeva N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Dolya O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Mahnovskaya T.S.

Peoples’ Friendship University of Russia

Zhdanovich A.V.

COMPANY «ECOLAB»

Laboratory diagnosis of neurosyphilis: optimization ways. Part II. Current approaches and biomarkers

Authors:

Potekaev N.N., Frigo N.V., Dmitriev G.A., Kitaeva N.V., Dolya O.V., Mahnovskaya T.S., Zhdanovich A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(1): 28‑36

DOI: 10.17116/klinderma20242301128

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To cite this article:

Potekaev NN, Frigo NV, Dmitriev GA, Kitaeva NV, Dolya OV, Mahnovskaya TS, Zhdanovich AV. Laboratory diagnosis of neurosyphilis: optimization ways. Part II. Current approaches and biomarkers. Russian Journal of Clinical Dermatology and Venereology. 2024;23(1):28‑36. (In Russ.)
https://doi.org/10.17116/klinderma20242301128

Подписка 2025 (Russian Journal of Clinical Dermatology and Venereology)
 
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Official statistics show an increase in the proportion of neurosyphilis (NS), which is a severe form of infection that is difficult to diagnose in a laboratory, against the background of decrease in the overall incidence of syphilis for recent decades in the Russian Federation. Literature data on using current approaches and new biomarkers, suggested for application in liquor diagnosis of NS, have been analyzed. In modern liquor diagnosis of NS, high hopes are placed on the application of indicators (indices) that identify the presence of antibodies’ intrathecal synthesis to T. pallidum, as well as on the development and implementation of immunochips in practice that determine antibodies to the most immunogenic recombinant proteins of T. pallidum. A direct detection of T. pallidum by metagenomic next-generation sequencing can be used in cases that are difficult for diagnosis. Complex of applied indicators can be assessed by using multidimensional discriminant analysis. Nonspecific molecular indicators of changes in CNS, including proteins, cytokines, chemokines, neurofilaments, as well as metabolomic profiles of CSF can be potential markers for assessing immunopathological process activity in NS.

Keywords:

neurosyphilis
diagnosis
indices of antibodies’ intrathecal synthesis
immunochips
multidimensional discriminant analysis
chemokines
cytokines
neurofilaments
proteins
metabolome
metagenomic sequencing

Authors:

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Dmitriev G.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Gabrichevsky Institute Of Epidemiology And Microbiology

Kitaeva N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Dolya O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Mahnovskaya T.S.

Peoples’ Friendship University of Russia

Zhdanovich A.V.

COMPANY «ECOLAB»

Received:

19.06.2023

Accepted:

16.11.2023

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