Investigation of the comprehensive treatment’s clinical efficacy of various types of alopecia using proteoglycan replacement therapy

Gadzhigoroeva A.G.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
LLC «Institute of Beautiful Hair»

ORCID: 0000-0003-0489-0576

Romanova Yu.Yu.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
LLC «Institute of Beautiful Hair»

ORCID: 0000-0001-6071-5145

Vavilov V.V.

LLC «Institute of Beautiful Hair»

ORCID: 0009-0009-0009-5867

Markova Yu.A.

LLC «Institute of Beautiful Hair»

ORCID: 0009-0000-9276-9084

Investigation of the comprehensive treatment’s clinical efficacy of various types of alopecia using proteoglycan replacement therapy

Authors:

Gadzhigoroeva A.G., Romanova Yu.Yu., Vavilov V.V., Markova Yu.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2023;22(4): 490‑498

DOI: 10.17116/klinderma202322041490

Downloaded: 39

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To cite this article:

Gadzhigoroeva AG, Romanova YuYu, Vavilov VV, Markova YuA. Investigation of the comprehensive treatment’s clinical efficacy of various types of alopecia using proteoglycan replacement therapy. Russian Journal of Clinical Dermatology and Venereology. 2023;22(4):490‑498. (In Russ.)
https://doi.org/10.17116/klinderma202322041490

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)

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Proteoglycans (PTG) of hair follicle (HF) play a key structural and regulatory role in cyclic mechanisms of HF development. Some of the PTGs have their own expression characteristics during the change of HF development phases, that confirms functional activity in HF biology. Dysregulation of PTG metabolism can indirectly cause the development of pathological processes with human hair growth irregularities. The aim of the study was to assess the tolerability, efficacy and adherence of adjuvant proteoglycan replacement therapy in the comprehensive treatment of patients with androgenetic alopecia (AGA) and telogen effluvium (TE). In dynamics, hair condition was studied in 42 patients (35 women and 7 men) with AGA (n=32) and TE (n=10) diagnosis. After a 4-month course of comprehensive therapy, 38 (90.5%) patients showed a positive dynamics in the form of pronounced improvement and improvement, including 28 (87.5%) patients with AGA and 10 (100%) patients with TE. The follow-up control of phototrichogram in 18 patients showed an improvement of all determined hair parameters in all patients with TE, and in all parameters except the average hair diameter in patients with AGA.

Keywords:

proteoglycans

hair follicles

growth phases

androgenetic alopecia

telogen effluvium

proteoglycan therapy

Authors:

Gadzhigoroeva A.G.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
LLC «Institute of Beautiful Hair»

ORCID: 0000-0003-0489-0576

Romanova Yu.Yu.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
LLC «Institute of Beautiful Hair»

ORCID: 0000-0001-6071-5145

Vavilov V.V.

LLC «Institute of Beautiful Hair»

ORCID: 0009-0009-0009-5867

Markova Yu.A.

LLC «Institute of Beautiful Hair»

ORCID: 0009-0000-9276-9084

Received:

31.05.2023

Accepted:

14.06.2023

List of references:

Iozzo RV and Schaefer L. Proteoglycan form and function: a comprehensive nomenclature of proteoglycans. Matrix Biology. 2015;42:11-55.
Couchman JR and Pataki CA. An introduction to proteoglycans and their localization. Journal of Histochemistry & Cytochemistry. 2012;60(12):885-897.
Couchman JR. Transmembrane signaling proteoglycans. Annu Rev Cell Dev Biol. 2010;26:89-114.
Roughley PJ. Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. Arthritis Research. 2001;3(6):342-347.
Rada JA, Cornuet PK, Hassell JR. Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycans (lumican and decorin) core proteins. Exp Eye Res. 1993;56:635-648.
Aspberg A. The different roles of aggrecan interaction domains. J Histochem Cytochem. 2012;60:987-996.
Iozzo RV, Zoeller JJ, Nystrom A. Basement membrane proteoglycans: modulators par excellence of cancer growth and angiogenesis. Mol Cells. 2009; 27:503-513.
Moretti G, Cipriani C, Rebora A, Rampini E and Crovato F. Correlation of tissue mucopolysaccharides with the hair cycle. Journal of Investigative Dermatology. 1967;48(6):498-503.
Malgouries S, Thibaut S and Bernard BA. Proteoglycan expression patterns in human hair follicle. Br J Dermatol. 2008;158(2):234-242.
Inui S and Itami S. A newly discovered linkage between proteoglycans and hair biology: decorin acts as an anagen inducer. Experimental Dermatology. 2014;23(8):547-548.
Soma T, Tajima M and Kishimoto J. Hair cycle-specific expression of versican in human hair follicles. Journal of Dermatological Science. 2005;39(3):147-154.
Botchkarev VA and Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. Journal of Investigative Dermatology Symposium Proceedings. 2003;8(1):46-55.
Jing J, Wu X-j, Li Y-l, Cai S-Q, Zheng M and Lu Z-F. Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation. Experimental Dermatology. 2014;23(7):486-491.
Yang Y, Li Y, Wang Y, et al. Versican gene: regulation by the β-catenin signaling pathway plays a significant role in dermal papilla cell aggregative growth. Journal of Dermatological Science. 2012;68(3):157-163.
Westgate GE, Messenger AG, Watson LP and Gibson WT. Distribution of proteoglycans during the hair growth cycle in human skin. Journal of Investigative Dermatology. 1991;96(2):191-195.
Theocharis AD, Skandalis SS, Tzanakakis GN and Karamanos NK. Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting. FEBS Journal. 2010;277(19):3904-3923.
Schaefer L and Iozzo RV. Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. Journal of Biological Chemistry. 2008;283(31):21305-21309.
Hassan GM, Ebrahim RH. The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction. Can J Physiol Pharmacol. 2023;101(6):286-293.
Gáspár R, Gömöri K, Kiss B, Szántai Á, Pálóczi J, Varga ZV, Pipis J, Váradi B, Ágg B, Csont T, Ferdinandy P, Barteková M, Görbe A. Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury. Molecules. 2020;25(15):3426.
Kelc R, Trapecar M, Gradisnik L, Rupnik MS, Vogrin M. Platelet-rich plasma, especially whencombined with a TGF- inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro. PLoS One. 2015; 10(2):e0117302.
Schlessinger J, Lax I and Lemmon M. Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell. 1995;83(3):357-360.
Couchman JR. Hair follicle proteoglycans. Journal of Investigative Dermatology. 1993;101(1):60-64.
Pataki CA, Couchman JR and Brabek J. Wnt signaling cascades and the roles of syndecan proteoglycans. Journal of Histochemistry & Cytochemistry. 2015; 63(7):465-480.
Kretzschmar K, Cottle DL, Schweiger PJ and Watt FM. The androgen receptor antagonizes wnt/β-catenin signaling in epidermal stem cells. Journal of Investigative Dermatology. 2015;135(11):2753-2763.
Elliott K, Messenger AG and Stephenson TJ. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. Journal of Investigative Dermatology. 1999;113(6):873-877.
De Weert J, Kint A and Geerts ML. Morphological changes in the proximal area of the rat’s hair follicle during early catagen. An electron-microscopic study. Archives of Dermatological Research. 1982;272(1-2):79-92.
Wadstein J, Thom E, Gadzhigoroeva A. Integlal Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium. J. Dermatology Research and Practice. 2020;2020:8125081. https://doi.org/10.1155/2020/8125081
Randall VA, Thornton MJ, Hamada K, et al. Mechanism of androgen action in cultured dermal papilla cells derived from human hair follicles with varying responses to androgens in vivo. Journal of Investigative Dermatology. 1992;98(6):86-91.
Randall VA, Thornton MJ, Hamada K, et al. Androgen action in cultured dermal papilla cells from human hair follicles. Skin Pharmacology and Physiology. 1994;7(1-2):20-26.
Maniatopoulou E, Bonovas S and Sitaras N. Isolation and quantification of glycosaminoglycans from human hair shaft. Annals of Dermatology. 2016; 28(5):533-539.

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