Background. A study of acne pathomorphology showed that multiple sebaceous follicles form microcomedones, which may undergo reverse development without progressing into visible inflammatory elements. Drugs that prevent acne are the drugs of choice.

OBJECTIVE

To study facial skin clinical and functional parameters in acne patients treated with aqua gel complex with 25% comedoclastin.

MATERIALS AND METHODS

Eight females and nine males (mean age 23.0±4.9 years) with various manifestations of acne were included in the study. Aqua gel complex with 25% comedoclastin was applied to the facial skin in the morning and evening for 2 months. The examination consisted of the questionnaire (subjective and objective skin assessment), facial photography, and determination of skin functional parameters (corneometry, sebumetry and mexametry) on Courage&Khazaka equipment (Germany) before and after treatment.

Statistical analysis included nonparametric estimation methods (Wilcoxon criterion), Kolmogorov-Smirnov agreement criteria, parametric criteria (Student's t-criterion), and Statistica v.10.0 software.

RESULTS

The drug reduced skin dryness, pore severity and decreased the number of comedones from 1.7 to 0.9 points (p<0.01).

After treatment, sebaceous excretions in the forehead area decreased by 42% (p>0.05). The moisture of the stratum corneum increased by 4–6% (p>0.05) in the forehead and cheek areas. The erythema decreased in the forehead and cheek area by 4–5% (p>0.05), and in the angle of the mouth by 14% (p<0.001). Melanin content decreased in the forehead and cheek areas by 5% (p>0.05) and in the angle of the mouth by 16% (p<0.001).

CONCLUSION

After 2 months of acne treatment with dermocosmetic aquagel complex with 25% comedoclastin, the amount of sebum and comedones decreased, skin hydration increased, and skin inflammation and pigmentation reduced. The product is well tolerated and can be recommended for use by dermatologists and beauticians.